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Items: 1 to 20 of 133


Chronic nicotine exposure stimulates biliary growth and fibrosis in normal rats.

Jensen K, Afroze S, Ueno Y, Rahal K, Frenzel A, Sterling M, Guerrier M, Nizamutdinov D, Dostal DE, Meng F, Glaser SS.

Dig Liver Dis. 2013 Sep;45(9):754-61. doi: 10.1016/j.dld.2013.02.023. Epub 2013 Apr 13.


Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression.

Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D.

Gastroenterology. 2008 Aug;135(2):660-70. doi: 10.1053/j.gastro.2008.04.009. Epub 2008 Apr 16.


H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.

Francis H, Franchitto A, Ueno Y, Glaser S, DeMorrow S, Venter J, Gaudio E, Alvaro D, Fava G, Marzioni M, Vaculin B, Alpini G.

Lab Invest. 2007 May;87(5):473-87. Epub 2007 Mar 5.


Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.

Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Ueno Y, Meininger CJ, Franchitto A, Onori P, Marzioni M, Taffetani S, Fava G, Stoica G, Venter J, Reichenbach R, De Morrow S, Summers R, Alpini G.

Gastroenterology. 2006 Apr;130(4):1270-82.


Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L748-L759. doi: 10.1152/ajplung.00393.2016. Epub 2017 Mar 3.


Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice.

Glaser S, Gaudio E, Renzi A, Mancinelli R, Ueno Y, Venter J, White M, Kopriva S, Chiasson V, DeMorrow S, Francis H, Meng F, Marzioni M, Franchitto A, Alvaro D, Supowit S, DiPette DJ, Onori P, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G297-305. doi: 10.1152/ajpgi.00418.2010. Epub 2011 May 19.


Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.

Francis HL, Demorrow S, Franchitto A, Venter JK, Mancinelli RA, White MA, Meng F, Ueno Y, Carpino G, Renzi A, Baker KK, Shine HE, Francis TC, Gaudio E, Alpini GD, Onori P.

Lab Invest. 2012 Feb;92(2):282-94. doi: 10.1038/labinvest.2011.158. Epub 2011 Nov 7.


Nicotine promotes cell proliferation and induces resistance to cisplatin by α7 nicotinic acetylcholine receptor‑mediated activation in Raw264.7 and El4 cells.

Wang YY, Liu Y, Ni XY, Bai ZH, Chen QY, Zhang Y, Gao FG.

Oncol Rep. 2014 Mar;31(3):1480-8. doi: 10.3892/or.2013.2962. Epub 2013 Dec 31.


Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms.

Taffetani S, Glaser S, Francis H, DeMorrow S, Ueno Y, Alvaro D, Marucci L, Marzioni M, Fava G, Venter J, Vaculin S, Vaculin B, Lam IP, Lee VH, Gaudio E, Carpino G, Benedetti A, Alpini G.

BMC Physiol. 2007 Jul 19;7:6.


cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.

Francis H, Glaser S, Ueno Y, Lesage G, Marucci L, Benedetti A, Taffetani S, Marzioni M, Alvaro D, Venter J, Reichenbach R, Fava G, Phinizy JL, Alpini G.

J Hepatol. 2004 Oct;41(4):528-37.


Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.

Glaser S, DeMorrow S, Francis H, Ueno Y, Gaudio E, Vaculin S, Venter J, Franchitto A, Onori P, Vaculin B, Marzioni M, Wise C, Pilanthananond M, Savage J, Pierce L, Mancinelli R, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G124-G136. doi: 10.1152/ajpgi.00536.2007. Epub 2008 May 29.


Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice.

Martínez AK, Jensen K, Hall C, O'Brien A, Ehrlich L, White T, Meng F, Zhou T, Greene J Jr, Bernuzzi F, Invernizzi P, Dostal DE, Lairmore T, Alpini G, Glaser SS.

Am J Pathol. 2017 May;187(5):1093-1105. doi: 10.1016/j.ajpath.2017.01.011. Epub 2017 Mar 14.


Immunohistochemical features of bile duct epithelial cells in normal and experimental liver conditions.

Onori P, Franchitto A, Alvaro D, Gaudio E.

Ital J Anat Embryol. 2001;106(2 Suppl 1):371-8.


Nicotine elevated intracellular Ca²⁺ in rat airway smooth muscle cells via activating and up-regulating α7-nicotinic acetylcholine receptor.

Jiang Y, Dai A, Zhou Y, Peng G, Hu G, Li B, Sham JS, Ran P.

Cell Physiol Biochem. 2014;33(2):389-401. doi: 10.1159/000356678. Epub 2014 Feb 6.


Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor.

Morioka N, Tokuhara M, Nakamura Y, Idenoshita Y, Harano S, Zhang FF, Hisaoka-Nakashima K, Nakata Y.

Neuroscience. 2014 Jan 31;258:374-84. doi: 10.1016/j.neuroscience.2013.11.044. Epub 2013 Dec 1.


Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2.

Fava G, Ueno Y, Glaser S, Francis H, Demorrow S, Marucci L, Marzioni M, Benedetti A, Venter J, Vaculin B, Vaculin S, Alpini G.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1467-75. Epub 2006 Dec 27.


Cholangiocyte proliferation and liver fibrosis.

Glaser SS, Gaudio E, Miller T, Alvaro D, Alpini G.

Expert Rev Mol Med. 2009 Feb 25;11:e7. doi: 10.1017/S1462399409000994. Review.


Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells.

Soeda J, Morgan M, McKee C, Mouralidarane A, Lin C, Roskams T, Oben JA.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):17-22. doi: 10.1016/j.bbrc.2011.10.151. Epub 2011 Nov 15.


Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation.

Glaser S, Lam IP, Franchitto A, Gaudio E, Onori P, Chow BK, Wise C, Kopriva S, Venter J, White M, Ueno Y, Dostal D, Carpino G, Mancinelli R, Butler W, Chiasson V, DeMorrow S, Francis H, Alpini G.

Hepatology. 2010 Jul;52(1):204-14. doi: 10.1002/hep.23657.


Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1.

Mancinelli R, Onori P, Gaudio E, DeMorrow S, Franchitto A, Francis H, Glaser S, Carpino G, Venter J, Alvaro D, Kopriva S, White M, Kossie A, Savage J, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G11-26. doi: 10.1152/ajpgi.00025.2009. Epub 2009 Apr 23.

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