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Items: 1 to 20 of 67

1.

Drugging Hedgehog: signaling the pathway to translation.

Carney TJ, Ingham PW.

BMC Biol. 2013 Apr 15;11:37. doi: 10.1186/1741-7007-11-37. Review.

2.

Development of anticancer agents targeting the Hedgehog signaling.

Zhang X, Tian Y, Yang Y, Hao J.

Cell Mol Life Sci. 2017 Aug;74(15):2773-2782. doi: 10.1007/s00018-017-2497-x. Epub 2017 Mar 17. Review.

PMID:
28314894
3.

Discovery of Hedgehog Antagonists for Cancer Therapy.

Khatra H, Bose C, Sinha S.

Curr Med Chem. 2017;24(19):2033-2058. doi: 10.2174/0929867324666170316115500. Review.

PMID:
28302010
4.

New developments in the discovery of small molecule Hedgehog pathway antagonists.

Tremblay MR, McGovern K, Read MA, Castro AC.

Curr Opin Chem Biol. 2010 Jun;14(3):428-35. doi: 10.1016/j.cbpa.2010.03.016.

PMID:
20399136
5.

Hedgehog pathway agonism: therapeutic potential and small-molecule development.

Hadden MK.

ChemMedChem. 2014 Jan;9(1):27-37. doi: 10.1002/cmdc.201300358. Epub 2013 Nov 7. Review.

PMID:
24203435
6.

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.

Yun JI, Kim HR, Park H, Kim SK, Lee J.

Arch Pharm Res. 2012 Aug;35(8):1317-33. doi: 10.1007/s12272-012-0801-8. Epub 2012 Sep 1. Review.

PMID:
22941475
7.

Targeting the hedgehog pathway: role in cancer and clinical implications of its inhibition.

Cohen DJ.

Hematol Oncol Clin North Am. 2012 Jun;26(3):565-88, viii. doi: 10.1016/j.hoc.2012.01.005. Review.

PMID:
22520980
8.

Overlapping activities of TGF-β and Hedgehog signaling in cancer: therapeutic targets for cancer treatment.

Perrot CY, Javelaud D, Mauviel A.

Pharmacol Ther. 2013 Feb;137(2):183-99. doi: 10.1016/j.pharmthera.2012.10.002. Epub 2012 Oct 11. Review.

PMID:
23063491
9.

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Scales SJ, de Sauvage FJ.

Trends Pharmacol Sci. 2009 Jun;30(6):303-12. doi: 10.1016/j.tips.2009.03.007. Epub 2009 May 13. Review.

PMID:
19443052
10.

Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway.

Sekulic A, Mangold AR, Northfelt DW, LoRusso PM.

Curr Opin Oncol. 2013 May;25(3):218-23. doi: 10.1097/CCO.0b013e32835ff438. Review.

PMID:
23493193
11.

Activation of Hedgehog pathway in gastrointestinal cancers.

Yang L, Su X, Xie J.

Vitam Horm. 2012;88:461-72. doi: 10.1016/B978-0-12-394622-5.00020-1. Review.

PMID:
22391316
12.

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.

Yang L, Xie G, Fan Q, Xie J.

Oncogene. 2010 Jan 28;29(4):469-81. doi: 10.1038/onc.2009.392. Epub 2009 Nov 23. Review.

PMID:
19935712
13.

Modulators of the hedgehog signaling pathway.

Heretsch P, Tzagkaroulaki L, Giannis A.

Bioorg Med Chem. 2010 Sep 15;18(18):6613-24. doi: 10.1016/j.bmc.2010.07.038. Epub 2010 Jul 23. Review.

PMID:
20708941
14.

Targeting Hedgehog--a cancer stem cell pathway.

Merchant AA, Matsui W.

Clin Cancer Res. 2010 Jun 15;16(12):3130-40. doi: 10.1158/1078-0432.CCR-09-2846. Epub 2010 Jun 8. Review.

15.

A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor.

Dash RC, Maschinot CR, Hadden MK.

Biochim Biophys Acta. 2017 Feb;1861(2):168-177. doi: 10.1016/j.bbagen.2016.11.003. Epub 2016 Nov 5.

PMID:
27825830
16.

Agents targeting the Hedgehog pathway for pancreatic cancer treatment.

Bisht S, Brossart P, Maitra A, Feldmann G.

Curr Opin Investig Drugs. 2010 Dec;11(12):1387-98. Review.

PMID:
21154121
17.

Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer.

Xu FG, Ma QY, Wang Z.

Cancer Lett. 2009 Oct 8;283(2):119-24. doi: 10.1016/j.canlet.2009.01.014. Epub 2009 Feb 15. Review.

PMID:
19232458
18.

Hedgehog signaling pathway: development of antagonists for cancer therapy.

Xie J.

Curr Oncol Rep. 2008 Mar;10(2):107-13. Review.

PMID:
18377823
19.

Small-molecule modulators of Hh and Wnt signaling pathways.

Kiselyov AS, Tkachenko SE, Balakin KV, Ivachtchenko AV.

Expert Opin Ther Targets. 2007 Aug;11(8):1087-101. Review.

PMID:
17665980
20.

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