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Items: 1 to 20 of 137

1.

The translation of translational control by FMRP: therapeutic targets for FXS.

Darnell JC, Klann E.

Nat Neurosci. 2013 Nov;16(11):1530-6. doi: 10.1038/nn.3379. Epub 2013 Apr 14. Review.

2.

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.

Ronesi JA, Huber KM.

Sci Signal. 2008 Feb 5;1(5):pe6. doi: 10.1126/stke.15pe6. Review.

PMID:
18272470
3.

The state of synapses in fragile X syndrome.

Pfeiffer BE, Huber KM.

Neuroscientist. 2009 Oct;15(5):549-67. doi: 10.1177/1073858409333075. Epub 2009 Mar 26. Review.

4.

microRNAs and Fragile X Syndrome.

Lin SL.

Adv Exp Med Biol. 2015;888:107-21. doi: 10.1007/978-3-319-22671-2_7.

PMID:
26663181
5.

Molecular mechanisms of fragile X syndrome: a twenty-year perspective.

Santoro MR, Bray SM, Warren ST.

Annu Rev Pathol. 2012;7:219-45. doi: 10.1146/annurev-pathol-011811-132457. Epub 2011 Oct 10. Review.

PMID:
22017584
6.

Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice.

Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK.

Hum Mol Genet. 2013 Mar 15;22(6):1180-92. doi: 10.1093/hmg/dds525. Epub 2012 Dec 18.

7.

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.

Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15537-42. Epub 2007 Sep 19.

8.

Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse.

Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y.

Hum Mol Genet. 2013 May 15;22(10):2041-54. doi: 10.1093/hmg/ddt055. Epub 2013 Feb 7.

9.

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Stone EF, Chen C, Fak JJ, Chi SW, Licatalosi DD, Richter JD, Darnell RB.

Cell. 2011 Jul 22;146(2):247-61. doi: 10.1016/j.cell.2011.06.013.

10.

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

Narayanan U, Nalavadi V, Nakamoto M, Thomas G, Ceman S, Bassell GJ, Warren ST.

J Biol Chem. 2008 Jul 4;283(27):18478-82. doi: 10.1074/jbc.C800055200. Epub 2008 May 12.

11.

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.

De Rubeis S, Fernández E, Buzzi A, Di Marino D, Bagni C.

Adv Exp Med Biol. 2012;970:517-51. doi: 10.1007/978-3-7091-0932-8_23. Review.

PMID:
22351071
12.

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.

Bassell GJ, Warren ST.

Neuron. 2008 Oct 23;60(2):201-14. doi: 10.1016/j.neuron.2008.10.004. Review.

13.

Fragile X syndrome: From protein function to therapy.

Bagni C, Oostra BA.

Am J Med Genet A. 2013 Nov;161A(11):2809-21. doi: 10.1002/ajmg.a.36241. Epub 2013 Sep 24. Review.

PMID:
24115651
14.

From FMRP function to potential therapies for fragile X syndrome.

Sethna F, Moon C, Wang H.

Neurochem Res. 2014 Jun;39(6):1016-31. doi: 10.1007/s11064-013-1229-3. Epub 2013 Dec 18. Review.

15.
16.

FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA.

Zhang Y, Gaetano CM, Williams KR, Bassell GJ, Mihailescu MR.

RNA Biol. 2014;11(11):1364-74. doi: 10.1080/15476286.2014.996464.

17.

Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules.

El Fatimy R, Davidovic L, Tremblay S, Jaglin X, Dury A, Robert C, De Koninck P, Khandjian EW.

PLoS Genet. 2016 Jul 27;12(7):e1006192. doi: 10.1371/journal.pgen.1006192. eCollection 2016 Jul.

18.

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome.

Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ.

J Neurosci. 2010 Aug 11;30(32):10624-38. doi: 10.1523/JNEUROSCI.0402-10.2010.

19.

Differential translation and fragile X syndrome.

Vanderklish PW, Edelman GM.

Genes Brain Behav. 2005 Aug;4(6):360-84. Review.

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