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Peroxidized unsaturated fatty acids stimulate Toll-like receptor 4 signaling in endothelial cells.

Mutoh A, Ueda S.

Life Sci. 2013 May 30;92(20-21):984-92. doi: 10.1016/j.lfs.2013.03.019. Epub 2013 Apr 10.


Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells.

Wang Y, Zhang MX, Meng X, Liu FQ, Yu GS, Zhang C, Sun T, Wang XP, Li L, Wang YY, Ding SF, Yang JM, Zhang Y.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1743-52. doi: 10.1152/ajpheart.01335.2008. Epub 2011 Feb 11.


Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.

Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH.

J Biol Chem. 2003 Sep 26;278(39):37041-51. Epub 2003 Jul 15.


Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH.

J Biol Chem. 2004 Apr 23;279(17):16971-9. Epub 2004 Feb 13.


Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.

Villacorta L, Chang L, Salvatore SR, Ichikawa T, Zhang J, Petrovic-Djergovic D, Jia L, Carlsen H, Schopfer FJ, Freeman BA, Chen YE.

Cardiovasc Res. 2013 Apr 1;98(1):116-24. doi: 10.1093/cvr/cvt002. Epub 2013 Jan 17.


Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids.

Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, Bray G, Hwang DH.

J Lipid Res. 2003 Mar;44(3):479-86. Epub 2002 Dec 1.


Statins attenuate high mobility group box-1 protein induced vascular endothelial activation : a key role for TLR4/NF-κB signaling pathway.

Yang J, Huang C, Yang J, Jiang H, Ding J.

Mol Cell Biochem. 2010 Dec;345(1-2):189-95. doi: 10.1007/s11010-010-0572-9. Epub 2010 Aug 17.


PPARalpha activator fenofibrate modulates angiotensin II-induced inflammatory responses in vascular smooth muscle cells via the TLR4-dependent signaling pathway.

Ji YY, Liu JT, Liu N, Wang ZD, Liu CH.

Biochem Pharmacol. 2009 Nov 1;78(9):1186-97. doi: 10.1016/j.bcp.2009.06.095. Epub 2009 Jul 1.


Saturated fatty acids do not directly stimulate Toll-like receptor signaling.

Erridge C, Samani NJ.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1944-9. doi: 10.1161/ATVBAHA.109.194050. Epub 2009 Aug 6.


Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.

Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA.

Hepatology. 2003 May;37(5):1043-55.


Nuclear factor translocation and acute anterior uveitis.

Wang J, Lu H, Hu X, Chen W, Xu Z, Li S, Xu Y.

Mol Vis. 2011 Jan 18;17:170-6.


The molecular mechanisms of the effect of Dexamethasone and Cyclosporin A on TLR4 /NF-κB signaling pathway activation in oral lichen planus.

Ge Y, Xu Y, Sun W, Man Z, Zhu L, Xia X, Zhao L, Zhao Y, Wang X.

Gene. 2012 Oct 25;508(2):157-64. doi: 10.1016/j.gene.2012.07.045. Epub 2012 Aug 8.


Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.

Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP, Arditi M.

J Immunol. 2002 Feb 1;168(3):1435-40.


Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts.

Yang X, Haghiac M, Glazebrook P, Minium J, Catalano PM, Hauguel-de Mouzon S.

Hum Reprod. 2015 Sep;30(9):2152-9. doi: 10.1093/humrep/dev173. Epub 2015 Jul 22.


Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.

Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH.

J Biol Chem. 2009 Oct 2;284(40):27384-92. doi: 10.1074/jbc.M109.044065. Epub 2009 Aug 1.


Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.

Li X, Tupper JC, Bannerman DD, Winn RK, Rhodes CJ, Harlan JM.

Infect Immun. 2003 Aug;71(8):4414-20.


Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4.

Lee JS, Lee JY, Lee MY, Hwang DH, Youn HS.

Mol Cells. 2008 Apr 30;25(2):253-7. Epub 2008 Mar 31.

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