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Items: 1 to 20 of 208

1.

Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.

Xu X, Hueckstaedt LK, Ren J.

J Hepatol. 2013 Aug;59(2):308-17. doi: 10.1016/j.jhep.2013.03.037. Epub 2013 Apr 11.

PMID:
23583271
2.

Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.

3.

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.

Hernández-Breijo B, Monserrat J, Román ID, González-Rodríguez Á, Fernández-Moreno MD, Lobo MV, Valverde ÁM, Gisbert JP, Guijarro LG.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78. doi: 10.1016/j.taap.2013.07.024. Epub 2013 Aug 16.

PMID:
23958494
4.

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D.

J Clin Invest. 2004 Jan;113(1):96-105.

5.

IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway.

Sobolewska A, Gajewska M, Zarzyńska J, Gajkowska B, Motyl T.

Eur J Cell Biol. 2009 Feb;88(2):117-30. doi: 10.1016/j.ejcb.2008.09.004. Epub 2008 Nov 14.

PMID:
19013662
6.

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

Diabetes. 2001 May;50(5):1110-8.

7.

GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model.

Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y.

Biochem Biophys Res Commun. 2012 Jun 29;423(2):295-300. doi: 10.1016/j.bbrc.2012.05.115. Epub 2012 May 30.

PMID:
22659415
8.

Effects of growth hormone and insulin-like growth factor-1 on hepatocyte antioxidative enzymes.

Brown-Borg HM, Rakoczy SG, Romanick MA, Kennedy MA.

Exp Biol Med (Maywood). 2002 Feb;227(2):94-104.

PMID:
11815672
9.

Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction.

Li Q, Ceylan-Isik AF, Li J, Ren J.

Rejuvenation Res. 2008 Aug;11(4):725-33. doi: 10.1089/rej.2008.0717.

10.

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007 Feb 16;100(3):434-43. Epub 2007 Jan 18.

12.

C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress.

Jung TW, Hong HC, Hwang HJ, Yoo HJ, Baik SH, Choi KM.

Mol Cell Endocrinol. 2015 Dec 5;417:131-40. doi: 10.1016/j.mce.2015.09.027. Epub 2015 Sep 28.

13.

Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis.

Rhee SD, Kim CH, Park JS, Jung WH, Park SB, Kim HY, Bae GH, Kim TJ, Kim KY.

Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. doi: 10.1016/j.ejphar.2012.06.021. Epub 2012 Jun 26.

PMID:
22742899
14.

Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy.

Wu D, Wang X, Zhou R, Yang L, Cederbaum AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1346-57. doi: 10.1016/j.freeradbiomed.2012.07.005. Epub 2012 Jul 20.

15.

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy.

Guo R, Xu X, Babcock SA, Zhang Y, Ren J.

J Hepatol. 2015 Mar;62(3):647-56. doi: 10.1016/j.jhep.2014.10.009. Epub 2014 Oct 20.

16.

Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage.

Li Q, Wu S, Li SY, Lopez FL, Du M, Kajstura J, Anversa P, Ren J.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1398-403. Epub 2006 Nov 3.

17.

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury.

Tamaki N, Hatano E, Taura K, Tada M, Kodama Y, Nitta T, Iwaisako K, Seo S, Nakajima A, Ikai I, Uemoto S.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G498-505. doi: 10.1152/ajpgi.00482.2007. Epub 2008 Jan 3.

18.

Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression.

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A.

Circ Res. 2004 Mar 5;94(4):514-24. Epub 2004 Jan 15.

19.
20.

Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy.

Zhou SW, Zhang M, Zhu M.

Mol Med Rep. 2014 Nov;10(5):2351-7. doi: 10.3892/mmr.2014.2569. Epub 2014 Sep 15.

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