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Items: 1 to 20 of 141


Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection.

Benfield CT, Ren H, Lucas SJ, Bahsoun B, Smith GL.

J Gen Virol. 2013 Jul;94(Pt 7):1647-57. doi: 10.1099/vir.0.052670-0. Epub 2013 Apr 11.


Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence.

Ferguson BJ, Benfield CT, Ren H, Lee VH, Frazer GL, Strnadova P, Sumner RP, Smith GL.

J Gen Virol. 2013 Sep;94(Pt 9):2070-81. doi: 10.1099/vir.0.054114-0. Epub 2013 Jun 12.


Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence.

Strnadova P, Ren H, Valentine R, Mazzon M, Sweeney TR, Brierley I, Smith GL.

PLoS Pathog. 2015 Sep 3;11(9):e1005151. doi: 10.1371/journal.ppat.1005151. eCollection 2015 Sep.


Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence.

Ember SW, Ren H, Ferguson BJ, Smith GL.

J Gen Virol. 2012 Oct;93(Pt 10):2098-108. doi: 10.1099/vir.0.045070-0. Epub 2012 Jul 12.


Vaccinia virus strain Western Reserve protein B14 is an intracellular virulence factor.

Chen RA, Jacobs N, Smith GL.

J Gen Virol. 2006 Jun;87(Pt 6):1451-8.


The Vaccinia virus complement control protein modulates adaptive immune responses during infection.

Girgis NM, Dehaven BC, Xiao Y, Alexander E, Viner KM, Isaacs SN.

J Virol. 2011 Mar;85(6):2547-56. doi: 10.1128/JVI.01474-10. Epub 2010 Dec 29.


Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.

Froggatt GC, Smith GL, Beard PM.

J Gen Virol. 2007 Jul;88(Pt 7):1917-21.


Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence.

Fahy AS, Clark RH, Glyde EF, Smith GL.

J Gen Virol. 2008 Oct;89(Pt 10):2377-87. doi: 10.1099/vir.0.2008/004895-0.


Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL, Bowie AG.

PLoS Pathog. 2011 Sep;7(9):e1002247. doi: 10.1371/journal.ppat.1002247. Epub 2011 Sep 8.


The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.

Symons JA, Adams E, Tscharke DC, Reading PC, Waldmann H, Smith GL.

J Gen Virol. 2002 Nov;83(Pt 11):2833-44.


Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice.

Dobson BM, Procter DJ, Hollett NA, Flesch IE, Newsome TP, Tscharke DC.

Virology. 2014 May;456-457:145-56. doi: 10.1016/j.virol.2014.03.020. Epub 2014 Apr 5.


Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection.

Abboud G, Tahiliani V, Desai P, Varkoly K, Driver J, Hutchinson TE, Salek-Ardakani S.

J Virol. 2015 Oct 14;90(1):129-41. doi: 10.1128/JVI.01894-15.


Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

Maluquer de Motes C, Cooray S, Ren H, Almeida GM, McGourty K, Bahar MW, Stuart DI, Grimes JM, Graham SC, Smith GL.

PLoS Pathog. 2011 Dec;7(12):e1002430. doi: 10.1371/journal.ppat.1002430. Epub 2011 Dec 15.


A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.

Peters NE, Ferguson BJ, Mazzon M, Fahy AS, Krysztofinska E, Arribas-Bosacoma R, Pearl LH, Ren H, Smith GL.

PLoS Pathog. 2013;9(10):e1003649. doi: 10.1371/journal.ppat.1003649. Epub 2013 Oct 3.


The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model.

Pires de Miranda M, Reading PC, Tscharke DC, Murphy BJ, Smith GL.

J Gen Virol. 2003 Sep;84(Pt 9):2459-71.


MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.

Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC.

J Virol. 2014 Mar;88(6):3557-67. doi: 10.1128/JVI.02776-13. Epub 2014 Jan 8.


Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.

Smith GL, Benfield CT, Maluquer de Motes C, Mazzon M, Ember SW, Ferguson BJ, Sumner RP.

J Gen Virol. 2013 Nov;94(Pt 11):2367-92. doi: 10.1099/vir.0.055921-0. Epub 2013 Sep 2. Review.


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