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Membrane channels formed by ceramide.

Colombini M.

Handb Exp Pharmacol. 2013;(215):109-26. doi: 10.1007/978-3-7091-1368-4_6. Review.


Ceramide channels and mitochondrial outer membrane permeability.

Colombini M.

J Bioenerg Biomembr. 2017 Feb;49(1):57-64. doi: 10.1007/s10863-016-9646-z. Epub 2016 Jan 22. Review.


Ceramide channels: destabilization by Bcl-xL and role in apoptosis.

Chang KT, Anishkin A, Patwardhan GA, Beverly LJ, Siskind LJ, Colombini M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2374-84. doi: 10.1016/j.bbamem.2015.07.013. Epub 2015 Jul 26.


Ceramide channels and their role in mitochondria-mediated apoptosis.

Colombini M.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1239-44. doi: 10.1016/j.bbabio.2010.01.021. Epub 2010 Jan 25. Review.


Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels.

Siskind LJ, Feinstein L, Yu T, Davis JS, Jones D, Choi J, Zuckerman JE, Tan W, Hill RB, Hardwick JM, Colombini M.

J Biol Chem. 2008 Mar 14;283(11):6622-30. doi: 10.1074/jbc.M706115200. Epub 2008 Jan 2.


Regulation of ceramide channels by Bcl-2 family proteins.

Ganesan V, Colombini M.

FEBS Lett. 2010 May 17;584(10):2128-34. doi: 10.1016/j.febslet.2010.02.032. Epub 2010 Feb 14. Review.


Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.

Perera MN, Lin SH, Peterson YK, Bielawska A, Szulc ZM, Bittman R, Colombini M.

Biochem J. 2012 Jul 1;445(1):81-91. doi: 10.1042/BJ20112103.


Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane.

Ganesan V, Perera MN, Colombini D, Datskovskiy D, Chadha K, Colombini M.

Apoptosis. 2010 May;15(5):553-62. doi: 10.1007/s10495-009-0449-0.


Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations.

BasaƱez G, Nechushtan A, Drozhinin O, Chanturiya A, Choe E, Tutt S, Wood KA, Hsu Y, Zimmerberg J, Youle RJ.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5492-7.


Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Nozawa Y.

Oncogene. 2000 Jul 20;19(31):3508-20. Erratum in: Oncogene. 2006 Nov 30;25(56):7440.


Ceramide channels: influence of molecular structure on channel formation in membranes.

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawski J, Bielawska A, Bittman R, Colombini M.

Biochim Biophys Acta. 2012 May;1818(5):1291-301. doi: 10.1016/j.bbamem.2012.02.010. Epub 2012 Feb 15.


Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator.

Brenner C, Cadiou H, Vieira HL, Zamzami N, Marzo I, Xie Z, Leber B, Andrews D, Duclohier H, Reed JC, Kroemer G.

Oncogene. 2000 Jan 20;19(3):329-36.


Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.

Siskind LJ, Fluss S, Bui M, Colombini M.

J Bioenerg Biomembr. 2005 Aug;37(4):227-36.


Inhibition of Bax channel-forming activity by Bcl-2.

Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod JJ, Mazzei G, Maundrell K, Gambale F, Sadoul R, Martinou JC.

Science. 1997 Jul 18;277(5324):370-2.


Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis.

Stiban J, Perera M.

Biochim Biophys Acta. 2015 Feb;1848(2):561-7. doi: 10.1016/j.bbamem.2014.11.018. Epub 2014 Nov 21.


The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis.

Siskind LJ, Colombini M.

J Biol Chem. 2000 Dec 8;275(49):38640-4.


Mitochondrial ceramide and the induction of apoptosis.

Siskind LJ.

J Bioenerg Biomembr. 2005 Jun;37(3):143-53. Review.


Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.

Siskind LJ, Kolesnick RN, Colombini M.

J Biol Chem. 2002 Jul 26;277(30):26796-803. Epub 2002 May 10.


The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability.

Harris MH, Thompson CB.

Cell Death Differ. 2000 Dec;7(12):1182-91. Review.


Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis.

Scharstuhl A, Mutsaers HA, Pennings SW, Russel FG, Wagener FA.

PLoS One. 2009 Aug 20;4(8):e6688. doi: 10.1371/journal.pone.0006688.

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