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Items: 1 to 20 of 151

1.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

2.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

3.

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.

Roosjen M, McColl B, Kao B, Gearing LJ, Blewitt ME, Vadolas J.

FASEB J. 2014 Apr;28(4):1610-20. doi: 10.1096/fj.13-242669. Epub 2013 Dec 26.

4.

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH.

Genes Dev. 2010 Apr 15;24(8):783-98. doi: 10.1101/gad.1897310.

5.

Transcriptional silencing of fetal hemoglobin by BCL11A.

Sankaran VG, Xu J, Orkin SH.

Ann N Y Acad Sci. 2010 Aug;1202:64-8. doi: 10.1111/j.1749-6632.2010.05574.x.

PMID:
20712774
6.

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment.

Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T.

Blood. 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.

7.

Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development.

McConnell SC, Huo Y, Liu S, Ryan TM.

Mol Cell Biol. 2011 Feb;31(4):876-83. doi: 10.1128/MCB.00725-10. Epub 2010 Dec 20.

8.

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus.

Jawaid K, Wahlberg K, Thein SL, Best S.

Blood Cells Mol Dis. 2010 Aug 15;45(2):140-6. doi: 10.1016/j.bcmd.2010.05.006. Epub 2010 Jun 12.

PMID:
20542454
9.

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227. Epub 2013 Feb 26.

10.

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D.

Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2.

PMID:
19576949
11.

Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

Ginder GD.

Transl Res. 2015 Jan;165(1):115-25. doi: 10.1016/j.trsl.2014.05.002. Epub 2014 May 11. Review.

12.

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH.

Science. 2011 Nov 18;334(6058):993-6. doi: 10.1126/science.1211053. Epub 2011 Oct 13.

13.

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.

14.

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.

Bauer DE, Kamran SC, Orkin SH.

Blood. 2012 Oct 11;120(15):2945-53. doi: 10.1182/blood-2012-06-292078. Epub 2012 Aug 17. Review.

15.

NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene.

Zhu X, Wang Y, Pi W, Liu H, Wickrema A, Tuan D.

PLoS One. 2012;7(10):e47175. doi: 10.1371/journal.pone.0047175. Epub 2012 Oct 10.

16.

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.

Vinjamur DS, Alhashem YN, Mohamad SF, Amin P, Williams DC Jr, Lloyd JA.

PLoS One. 2016 Feb 3;11(2):e0146802. doi: 10.1371/journal.pone.0146802. eCollection 2016.

17.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH.

Science. 2013 Oct 11;342(6155):253-7. doi: 10.1126/science.1242088.

18.

MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.

Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, Giuliani A, Marziali G.

PLoS One. 2013 Apr 4;8(4):e60436. doi: 10.1371/journal.pone.0060436. Print 2013.

19.

Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.

Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J.

Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8.

20.

Chromatin regulation: how complex does it get?

Meier K, Brehm A.

Epigenetics. 2014 Nov;9(11):1485-95. doi: 10.4161/15592294.2014.971580. Review.

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