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Items: 1 to 20 of 114


Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus.

Gruber HE, Watts JA, Riley FE, Fulkerson MB, Norton HJ, Hanley EN Jr.

J Orthop Res. 2013 Aug;31(8):1270-5. doi: 10.1002/jor.22361. Epub 2013 Apr 10.


Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Mol Pain. 2012 Sep 10;8:63. doi: 10.1186/1744-8069-8-63.


Ex vivo observation of human intervertebral disc tissue and cells isolated from degenerated intervertebral discs.

Ciapetti G, Granchi D, Devescovi V, Leonardi E, Greggi T, Di Silvestre M, Baldini N.

Eur Spine J. 2012 May;21 Suppl 1:S10-9. doi: 10.1007/s00586-012-2234-y. Epub 2012 Mar 7.


Mitochondrial Membrane Potential and Nuclear and Gene Expression Changes During Human Disc Cell Apoptosis: In Vitro and In Vivo Annulus Findings.

Gruber HE, Hoelscher GL, Bethea S, Hanley EN Jr.

Spine (Phila Pa 1976). 2015 Jun 15;40(12):876-82. doi: 10.1097/BRS.0000000000000936.


Do intervertebral discs degenerate before they herniate, or after?

Lama P, Le Maitre CL, Dolan P, Tarlton JF, Harding IJ, Adams MA.

Bone Joint J. 2013 Aug;95-B(8):1127-33. doi: 10.1302/0301-620X.95B8.31660.


Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells.

Gruber HE, Watts JA, Hoelscher GL, Bethea SF, Ingram JA, Zinchenko NS, Hanley EN Jr.

Spine J. 2011 Aug;11(8):782-91. doi: 10.1016/j.spinee.2011.06.012. Epub 2011 Jul 23.


Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs : Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs.

Rajasekaran S, Venkatadass K, Naresh Babu J, Ganesh K, Shetty AP.

Eur Spine J. 2008 May;17(5):626-43. doi: 10.1007/s00586-008-0645-6. Epub 2008 Mar 21.


Senescence in human intervertebral discs.

Roberts S, Evans EH, Kletsas D, Jaffray DC, Eisenstein SM.

Eur Spine J. 2006 Aug;15 Suppl 3:S312-6. Epub 2006 Jun 14.


Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.

Zhang Z, Kakutani K, Maeno K, Takada T, Yurube T, Doita M, Kurosaka M, Nishida K.

Arthritis Res Ther. 2011;13(6):R200. doi: 10.1186/ar3533. Epub 2011 Dec 8.


Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs.

Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ, Hanley EN Jr.

Arthritis Res Ther. 2009;11(6):R184. doi: 10.1186/ar2876. Epub 2009 Dec 9.


Morphologic complexity of the pericellular matrix in the annulus of the human intervertebral disc.

Gruber HE, Ingram JA, Hanley EN Jr.

Biotech Histochem. 2007 Aug;82(4-5):217-25.


Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc.

Weiler C, Nerlich AG, Schaaf R, Bachmeier BE, Wuertz K, Boos N.

Eur Spine J. 2010 Oct;19(10):1761-70. doi: 10.1007/s00586-010-1392-z. Epub 2010 Apr 7.


The relationship between pregnancy-associated plasma protein-A (PAPP-A) and human intervertebral disc degeneration.

Gruber HE, Buchanan L, Ingram JA, Zinchenko N, Norton HJ, Hanley EN Jr.

Histol Histopathol. 2010 Nov;25(11):1431-6. doi: 10.14670/HH-25.1431.


High-mobility group box-1 gene, a potent proinflammatory mediators, is upregulated in more degenerated human discs in vivo and its receptor upregulated by TNF-α exposure in vitro.

Gruber HE, Hoelscher GL, Bethea S, Ingram J, Cox M, Hanley EN Jr.

Exp Mol Pathol. 2015 Jun;98(3):427-30. doi: 10.1016/j.yexmp.2015.03.001. Epub 2015 Mar 4.


Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?

Aoki Y, Nakajima A, Ohtori S, Takahashi H, Watanabe F, Sonobe M, Terajima F, Saito M, Takahashi K, Toyone T, Watanabe A, Nakajima T, Takazawa M, Nakagawa K.

Arthritis Res Ther. 2014 Jul 28;16(4):R159. doi: 10.1186/ar4674.


Relationship between neovascularization and degenerative changes in herniated lumbar intervertebral discs.

Rätsep T, Minajeva A, Asser T.

Eur Spine J. 2013 Nov;22(11):2474-80. doi: 10.1007/s00586-013-2842-1. Epub 2013 Jun 5.


Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Exp Mol Pathol. 2012 Feb;92(1):59-63. doi: 10.1016/j.yexmp.2011.09.008. Epub 2011 Sep 14.


Deleterious effects of discography radiocontrast solution on human annulus cell in vitro: changes in cell viability, proliferation, and apoptosis in exposed cells.

Gruber HE, Rhyne AL 3rd, Hansen KJ, Phillips RC, Hoelscher GL, Ingram JA, Norton HJ, Hanley EN Jr.

Spine J. 2012 Apr;12(4):329-35. doi: 10.1016/j.spinee.2012.02.003. Epub 2012 Mar 16.


Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease.

Melrose J, Burkhardt D, Taylor TK, Dillon CT, Read R, Cake M, Little CB.

Eur Spine J. 2009 Apr;18(4):479-89. doi: 10.1007/s00586-008-0871-y. Epub 2009 Jan 23.

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