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Items: 1 to 20 of 116

1.

Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.

Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M.

Mol Cell Biol. 2013 Jun;33(12):2402-12. doi: 10.1128/MCB.00065-13. Epub 2013 Apr 9.

2.

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers.

Yamadori T, Ishii Y, Homma S, Morishima Y, Kurishima K, Itoh K, Yamamoto M, Minami Y, Noguchi M, Hizawa N.

Oncogene. 2012 Nov 8;31(45):4768-77. doi: 10.1038/onc.2011.628. Epub 2012 Jan 16.

PMID:
22249257
3.

LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.

Kaufman JM, Amann JM, Park K, Arasada RR, Li H, Shyr Y, Carbone DP.

J Thorac Oncol. 2014 Jun;9(6):794-804. doi: 10.1097/JTO.0000000000000173.

4.

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.

Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S.

Am J Respir Cell Mol Biol. 2006 Dec;35(6):639-50. Epub 2006 Jun 22. Erratum in: Am J Respir Cell Mol Biol. 2007 May;36(5):642.

5.

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S.

PLoS Med. 2006 Oct;3(10):e420.

7.

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13568-73. doi: 10.1073/pnas.0806268105. Epub 2008 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10393.

8.

Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.

Tanigawa S, Fujii M, Hou DX.

Free Radic Biol Med. 2007 Jun 1;42(11):1690-703. Epub 2007 Feb 28.

PMID:
17462537
9.

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.

Sun Z, Zhang S, Chan JY, Zhang DD.

Mol Cell Biol. 2007 Sep;27(18):6334-49. Epub 2007 Jul 16.

10.

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Uruno A, Motohashi H.

Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007. Epub 2011 Mar 6.

PMID:
21385624
11.

Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease.

Müller T, Hengstermann A.

Chem Res Toxicol. 2012 Sep 17;25(9):1805-24. doi: 10.1021/tx300145n. Epub 2012 Jun 22. Review.

PMID:
22686525
12.

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S.

Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. doi: 10.1165/rcmb.2009-0054OC. Epub 2009 Jun 11.

13.

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K, Motohashi H, Yamamoto M.

Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x. Review.

14.

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T.

J Biol Chem. 2010 Jul 16;285(29):22576-91. doi: 10.1074/jbc.M110.118976. Epub 2010 May 7.

15.

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.

16.

Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

Yang SP, Yang XZ, Cao GP.

Mol Med Rep. 2015 Jul;12(1):1145-50. doi: 10.3892/mmr.2015.3490. Epub 2015 Mar 13.

PMID:
25776802
17.

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.

Kang HJ, Hong YB, Kim HJ, Bae I.

J Biol Chem. 2010 Jul 9;285(28):21258-68. doi: 10.1074/jbc.M109.084590. Epub 2010 Apr 28.

18.

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.

Cancer Res. 2013 Apr 1;73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.

19.

Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells.

Zhan L, Zhang H, Zhang Q, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J.

Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.

20.

Nrf2 protects against airway disorders.

Cho HY, Kleeberger SR.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):43-56. doi: 10.1016/j.taap.2009.07.024. Epub 2009 Jul 29. Review. Erratum in: Toxicol Appl Pharmacol. 2010 Aug 1;246(3):186-7.

PMID:
19646463

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