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The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse.

Diaz JA, Alvarado CM, Wrobleski SK, Slack DW, Hawley AE, Farris DM, Henke PK, Wakefield TW, Myers DD Jr.

Thromb Haemost. 2013 Jun;109(6):1158-69. doi: 10.1160/TH12-09-0711. Epub 2013 Mar 28.


Thrombogenesis with continuous blood flow in the inferior vena cava. A novel mouse model.

Diaz JA, Hawley AE, Alvarado CM, Berguer AM, Baker NK, Wrobleski SK, Wakefield TW, Lucchesi BR, Myers DD Jr.

Thromb Haemost. 2010 Aug;104(2):366-75. doi: 10.1160/TH09-09-0672. Epub 2010 Jun 29.


Electrolytic inferior vena cava model (EIM) of venous thrombosis.

Diaz JA, Wrobleski SK, Hawley AE, Lucchesi BR, Wakefield TW, Myers DD Jr.

J Vis Exp. 2011 Jul 12;(53):e2737. doi: 10.3791/2737.


Circulating and vein wall P-selectin promote venous thrombogenesis during aging in a rodent model.

Culmer DL, Diaz JA, Hawley AE, Jackson TO, Shuster KA, Sigler RE, Wakefield TW, Myers DD Jr.

Thromb Res. 2013 Jan;131(1):42-8. doi: 10.1016/j.thromres.2012.10.013. Epub 2012 Nov 20.


Inferior vena cava branch variations in C57BL/6 mice have an impact on thrombus size in an IVC ligation (stasis) model.

Diaz JA, Farris DM, Wrobleski SK, Myers DD, Wakefield TW.

J Thromb Haemost. 2015 Apr;13(4):660-4. doi: 10.1111/jth.12866. Epub 2015 Mar 13.


Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis.

Diaz JA, Ballard-Lipka NE, Farris DM, Hawley AE, Wrobleski SK, Myers DD, Henke PK, Lawrence DA, Wakefield TW.

J Vasc Surg. 2012 Mar;55(3):815-22. doi: 10.1016/j.jvs.2011.08.038. Epub 2011 Nov 25.


Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis.

Downing LJ, Wakefield TW, Strieter RM, Prince MR, Londy FJ, Fowlkes JB, Hulin MS, Kadell AM, Wilke CA, Brown SL, Wrobleski SK, Burdick MD, Anderson DC, Greenfield LJ.

J Vasc Surg. 1997 May;25(5):816-27; discussion 828.


Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis.

Myers DD Jr, Henke PK, Bedard PW, Wrobleski SK, Kaila N, Shaw G, Meier TR, Hawley AE, Schaub RG, Wakefield TW.

J Vasc Surg. 2006 Sep;44(3):625-32.


Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis.

Ramacciotti E, Hawley AE, Farris DM, Ballard NE, Wrobleski SK, Myers DD Jr, Henke PK, Wakefield TW.

Thromb Haemost. 2009 Apr;101(4):748-54.


Decreased venous thrombosis with an oral inhibitor of P selectin.

Myers DD Jr, Rectenwald JE, Bedard PW, Kaila N, Shaw GD, Schaub RG, Farris DM, Hawley AE, Wrobleski SK, Henke PK, Wakefield TW.

J Vasc Surg. 2005 Aug;42(2):329-36.


P-selectin and leukocyte microparticles are associated with venous thrombogenesis.

Myers DD, Hawley AE, Farris DM, Wrobleski SK, Thanaporn P, Schaub RG, Wagner DD, Kumar A, Wakefield TW.

J Vasc Surg. 2003 Nov;38(5):1075-89. Erratum in: J Vasc Surg. 2004 Jan;39(1):188.


The effect of matrix metalloproteinase 2 and matrix metalloproteinase 2/9 deletion in experimental post-thrombotic vein wall remodeling.

Deatrick KB, Luke CE, Elfline MA, Sood V, Baldwin J, Upchurch GR Jr, Jaffer FA, Wakefield TW, Henke PK.

J Vasc Surg. 2013 Nov;58(5):1375-1384.e2. doi: 10.1016/j.jvs.2012.11.088. Epub 2013 Mar 13.


Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution.

Evans CE, Humphries J, Waltham M, Saha P, Mattock K, Patel A, Ahmad A, Wadoodi A, Modarai B, Burnand K, Smith A.

Thromb Res. 2011 Oct;128(4):346-51. doi: 10.1016/j.thromres.2011.05.006. Epub 2011 May 31.


P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model.

Myers DD Jr, Henke PK, Wrobleski SK, Hawley AE, Farris DM, Chapman AM, Knipp BS, Thanaporn P, Schaub RG, Greenfield LJ, Wakefield TW.

J Vasc Surg. 2002 Nov;36(5):928-38.


Male mice have increased thrombotic potential: sex differences in a mouse model of venous thrombosis.

Alvarado CM, Diaz JA, Hawley AE, Wrobleski SK, Sigler RE, Myers DD Jr.

Thromb Res. 2011 May;127(5):478-86. doi: 10.1016/j.thromres.2011.01.004. Epub 2011 Feb 5.


Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy.

Wakefield TW, Strieter RM, Schaub R, Myers DD, Prince MR, Wrobleski SK, Londy FJ, Kadell AM, Brown SL, Henke PK, Greenfield LJ.

J Vasc Surg. 2000 Feb;31(2):309-24.


Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches.

Brandt M, Schönfelder T, Schwenk M, Becker C, Jäckel S, Reinhardt C, Stark K, Massberg S, Münzel T, von Brühl ML, Wenzel P.

Clin Hemorheol Microcirc. 2014;56(2):145-52. doi: 10.3233/CH-131680.


Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, Kirchhofer D, Sigler RE, Wakefield TW, Mackman N, Myers DD Jr.

Thromb Res. 2012 Oct;130(4):640-5. doi: 10.1016/j.thromres.2011.11.027. Epub 2011 Dec 20.


The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis.

Baldwin JF, Sood V, Elfline MA, Luke CE, Dewyer NA, Diaz JA, Myers DD, Wakefield T, Henke PK.

J Vasc Surg. 2012 Oct;56(4):1089-97. doi: 10.1016/j.jvs.2012.02.054. Epub 2012 Jul 15.


Deletion of cysteine-cysteine receptor 7 promotes fibrotic injury in experimental post-thrombotic vein wall remodeling.

Laser A, Elfline M, Luke C, Slack D, Shah A, Sood V, Deatrick B, McEvoy B, Ostra C, Comerota A, Kunkel S, Hogaboam C, Henke PK.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):377-85. doi: 10.1161/ATVBAHA.113.302428. Epub 2013 Dec 5.

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