Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 108

1.

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders.

Safavi M, Baeeri M, Abdollahi M.

Expert Opin Drug Discov. 2013 Jun;8(6):733-51. doi: 10.1517/17460441.2013.787986. Epub 2013 Apr 9. Review.

PMID:
23570245
2.

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.

Martinez A, Gil C.

Expert Opin Ther Pat. 2014 Dec;24(12):1311-21. doi: 10.1517/13543776.2014.968127. Epub 2014 Oct 4. Review.

3.

PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research.

Jankowska A, Swierczek A, Chlon-Rzepa G, Pawlowski M, Wyska E.

Curr Med Chem. 2017;24(7):673-700. doi: 10.2174/0929867324666170116125159. Review.

PMID:
28093982
4.

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example.

Castro A, Jerez MJ, Gil C, Calderón F, Doménech T, Nueda A, Martínez A.

Eur J Med Chem. 2008 Jul;43(7):1349-59. Epub 2007 Dec 21.

PMID:
18082290
5.

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.

Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1935-8. doi: 10.1016/j.bmcl.2009.02.060. Epub 2009 Feb 21.

PMID:
19272774
6.

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities.

Redondo M, Soteras I, Brea J, González-García A, Cadavid MI, Loza MI, Martinez A, Gil C, Campillo NE.

Eur J Med Chem. 2013;70:781-8. doi: 10.1016/j.ejmech.2013.10.035. Epub 2013 Oct 22.

PMID:
24239625
7.

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury.

Paterniti I, Mazzon E, Gil C, Impellizzeri D, Palomo V, Redondo M, Perez DI, Esposito E, Martinez A, Cuzzocrea S.

PLoS One. 2011 Jan 31;6(1):e15937. doi: 10.1371/journal.pone.0015937.

8.

Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.

Endo Y, Kawai K, Asano T, Amano S, Asanuma Y, Sawada K, Ogura K, Nagata N, Ueo N, Takahashi N, Sonoda Y, Kamei N.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):649-53. doi: 10.1016/j.bmcl.2014.11.090. Epub 2014 Dec 6.

PMID:
25529739
9.

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.

García AM, Brea J, Morales-García JA, Perez DI, González A, Alonso-Gil S, Gracia-Rubio I, Ros-Simó C, Conde S, Cadavid MI, Loza MI, Perez-Castillo A, Valverde O, Martinez A, Gil C.

J Med Chem. 2014 Oct 23;57(20):8590-607. doi: 10.1021/jm501090m. Epub 2014 Oct 8.

PMID:
25264825
10.

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.

Redondo M, Brea J, Perez DI, Soteras I, Val C, Perez C, Morales-García JA, Alonso-Gil S, Paul-Fernandez N, Martin-Alvarez R, Cadavid MI, Loza MI, Perez-Castillo A, Mengod G, Campillo NE, Martinez A, Gil C.

J Med Chem. 2012 Apr 12;55(7):3274-84. doi: 10.1021/jm201720d. Epub 2012 Mar 16.

PMID:
22385507
11.

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.

Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O.

Clin Exp Immunol. 2002 Jun;128(3):460-6.

12.

Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors.

Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C.

ChemMedChem. 2009 May;4(5):866-76. doi: 10.1002/cmdc.200900043.

13.

Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts.

Pekkinen M, Ahlström MEB, Riehle U, Huttunen MM, Lamberg-Allardt CJE.

Bone. 2008 Jul;43(1):84-91. doi: 10.1016/j.bone.2008.02.021. Epub 2008 Mar 12.

PMID:
18420479
14.

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.

Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13.

PMID:
15324874
15.

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.

Sánchez AI, Meneses R, Mínguez JM, Núñez A, Castillo RR, Filace F, Burgos C, Vaquero JJ, Álvarez-Builla J, Cortés-Cabrera A, Gago F, Terricabras E, Segarra V.

Org Biomol Chem. 2014 Jun 28;12(24):4233-42. doi: 10.1039/c4ob00175c.

PMID:
24838636
16.

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.

Lorthiois E, Bernardelli P, Vergne F, Oliveira C, Mafroud AK, Proust E, Heuze L, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Wrigglesworth R, Descours A, Soulard P, Berna P.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4623-6.

PMID:
15324876
17.

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1829-33.

PMID:
15780616
18.

Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors.

Kawai K, Endo Y, Asano T, Amano S, Sawada K, Ueo N, Takahashi N, Sonoda Y, Nagai M, Kamei N, Nagata N.

J Med Chem. 2014 Dec 11;57(23):9844-54. doi: 10.1021/jm5008215. Epub 2014 Nov 19.

PMID:
25383422
19.

Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors.

Sánchez AI, Martínez-Barrasa V, Burgos C, Vaquero JJ, Alvarez-Builla J, Terricabras E, Segarra V.

Bioorg Med Chem. 2013 Apr 15;21(8):2370-2378. doi: 10.1016/j.bmc.2013.01.067. Epub 2013 Feb 5.

PMID:
23454131
20.

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.

Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Ducrot P, Wrigglesworth R, Berlioz-Seux F, Coleon F, Chevalier E, Moreau F, Idrissi M, Tertre A, Descours A, Berna P, Li M.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4615-21.

PMID:
15324875

Supplemental Content

Support Center