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Items: 1 to 20 of 152

1.

Asparagine deamidation dependence on buffer type, pH, and temperature.

Pace AL, Wong RL, Zhang YT, Kao YH, Wang YJ.

J Pharm Sci. 2013 Jun;102(6):1712-23. doi: 10.1002/jps.23529. Epub 2013 Apr 9.

PMID:
23568760
2.

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping.

Zhang YT, Hu J, Pace AL, Wong R, Wang YJ, Kao YH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:65-71. doi: 10.1016/j.jchromb.2014.06.018. Epub 2014 Jun 21.

PMID:
24999246
3.

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.

Sinha S, Zhang L, Duan S, Williams TD, Vlasak J, Ionescu R, Topp EM.

Protein Sci. 2009 Aug;18(8):1573-84. doi: 10.1002/pro.173.

4.

Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.

Diepold K, Bomans K, Wiedmann M, Zimmermann B, Petzold A, Schlothauer T, Mueller R, Moritz B, Stracke JO, Mølhøj M, Reusch D, Bulau P.

PLoS One. 2012;7(1):e30295. doi: 10.1371/journal.pone.0030295. Epub 2012 Jan 17.

5.
6.

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

Yan B, Steen S, Hambly D, Valliere-Douglass J, Vanden Bos T, Smallwood S, Yates Z, Arroll T, Han Y, Gadgil H, Latypov RF, Wallace A, Lim A, Kleemann GR, Wang W, Balland A.

J Pharm Sci. 2009 Oct;98(10):3509-21. doi: 10.1002/jps.21655.

PMID:
19475547
7.
8.

Human antibody Fc deamidation in vivo.

Liu YD, van Enk JZ, Flynn GC.

Biologicals. 2009 Oct;37(5):313-22. doi: 10.1016/j.biologicals.2009.06.001. Epub 2009 Jul 15.

PMID:
19608432
9.

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

Huang L, Lu J, Wroblewski VJ, Beals JM, Riggin RM.

Anal Chem. 2005 Mar 1;77(5):1432-9.

PMID:
15732928
10.

Characterization of the acidic species of a monoclonal antibody using weak cation exchange chromatography and LC-MS.

Ponniah G, Kita A, Nowak C, Neill A, Kori Y, Rajendran S, Liu H.

Anal Chem. 2015 Sep 1;87(17):9084-92. doi: 10.1021/acs.analchem.5b02385. Epub 2015 Aug 11.

PMID:
26222016
11.

Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments.

Welfle K, Misselwitz R, Hausdorf G, Höhne W, Welfle H.

Biochim Biophys Acta. 1999 Apr 12;1431(1):120-31.

PMID:
10209285
12.

Characterization of a unique IgG1 mAb CEX profile by limited Lys-C proteolysis/CEX separation coupled with mass spectrometry and structural analysis.

Kim J, Jones L, Taylor L, Kannan G, Jackson F, Lau H, Latypov RF, Bailey B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 15;878(22):1973-81. doi: 10.1016/j.jchromb.2010.05.032. Epub 2010 Jun 1.

PMID:
20554483
13.

Effect of pH, temperature, and salt on the stability of Escherichia coli- and Chinese hamster ovary cell-derived IgG1 Fc.

Li CH, Narhi LO, Wen J, Dimitrova M, Wen ZQ, Li J, Pollastrini J, Nguyen X, Tsuruda T, Jiang Y.

Biochemistry. 2012 Dec 18;51(50):10056-65. doi: 10.1021/bi300702e. Epub 2012 Dec 4.

PMID:
23078371
14.

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

Vlasak J, Bussat MC, Wang S, Wagner-Rousset E, Schaefer M, Klinguer-Hamour C, Kirchmeier M, Corvaïa N, Ionescu R, Beck A.

Anal Biochem. 2009 Sep 15;392(2):145-54. doi: 10.1016/j.ab.2009.05.043. Epub 2009 Jun 2.

PMID:
19497295
15.

Protein aggregation kinetics during Protein A chromatography. Case study for an Fc fusion protein.

Shukla AA, Gupta P, Han X.

J Chromatogr A. 2007 Nov 9;1171(1-2):22-8. Epub 2007 Sep 22.

PMID:
17920607
16.

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion.

Moorhouse KG, Nashabeh W, Deveney J, Bjork NS, Mulkerrin MG, Ryskamp T.

J Pharm Biomed Anal. 1997 Dec;16(4):593-603.

PMID:
9502155
17.

Glutamine deamidation of a recombinant monoclonal antibody.

Liu H, Gaza-Bulseco G, Chumsae C.

Rapid Commun Mass Spectrom. 2008 Dec;22(24):4081-8. doi: 10.1002/rcm.3831.

PMID:
19021137
18.

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength.

Zhang L, Patapoff T, Farnan D, Zhang B.

J Chromatogr A. 2013 Jan 11;1272:56-64. doi: 10.1016/j.chroma.2012.11.060. Epub 2012 Nov 29.

PMID:
23253120
19.

Effect of 'pH' on the rate of asparagine deamidation in polymeric formulations: 'pH'-rate profile.

Song Y, Schowen RL, Borchardt RT, Topp EM.

J Pharm Sci. 2001 Feb;90(2):141-56.

PMID:
11169531
20.

Selective deamidation of recombinant human stem cell factor during in vitro aging: isolation and characterization of the aspartyl and isoaspartyl homodimers and heterodimers.

Hsu YR, Chang WC, Mendiaz EA, Hara S, Chow DT, Mann MB, Langley KE, Lu HS.

Biochemistry. 1998 Feb 24;37(8):2251-62.

PMID:
9485371

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