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Items: 1 to 20 of 96

1.

PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.

PLoS One. 2013;8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.

2.

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.

Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A.

Eur J Immunol. 2011 Jul;41(7):2074-85. doi: 10.1002/eji.201041196. Epub 2011 Jun 7.

3.

Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth.

Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA.

Cancer Res. 2011 Nov 15;71(22):6965-75. doi: 10.1158/0008-5472.CAN-11-0588. Epub 2011 Sep 23.

4.

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA.

Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016.

5.

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M.

Blood. 2015 Dec 17;126(25):2704-12. doi: 10.1182/blood-2015-05-647453. Epub 2015 Sep 3.

6.

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.

Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN.

Blood. 2007 Nov 15;110(10):3682-90. Epub 2007 Aug 16.

7.

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.

Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E.

Blood. 2009 Jan 8;113(2):488-97. doi: 10.1182/blood-2008-02-138438. Epub 2008 Sep 19.

8.

CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M.

J Biol Chem. 2000 Aug 18;275(33):25488-93.

9.

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2.

Guo FF, Kumahara E, Saffen D.

J Biol Chem. 2001 Jul 6;276(27):25568-81. Epub 2001 Apr 5.

10.

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH.

Curr Biol. 2006 Sep 19;16(18):1796-806.

11.

DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1.

García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Samaniego R, Fukui Y, Stein JV, Teixidó J.

J Immunol. 2006 Oct 15;177(8):5215-25.

12.
13.

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83. Erratum in: Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318.

14.

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.

Stefanini L, Roden RC, Bergmeier W.

Blood. 2009 Sep 17;114(12):2506-14. doi: 10.1182/blood-2009-04-218768. Epub 2009 Jul 23.

15.

Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.

Arai A, Nosaka Y, Kanda E, Yamamoto K, Miyasaka N, Miura O.

J Biol Chem. 2001 Mar 30;276(13):10453-62. Epub 2000 Dec 21.

16.

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.

Fujita M, Zhu K, Fujita CK, Zhao M, Lam KS, Kurth MJ, Takada YK, Takada Y.

J Biol Chem. 2015 Jan 2;290(1):259-71. doi: 10.1074/jbc.M114.579946. Epub 2014 Nov 14.

17.

Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration.

Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA.

Mol Biol Cell. 2009 Apr;20(7):1916-25. doi: 10.1091/mbc.E08-10-1014. Epub 2009 Jan 28.

18.

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function.

García-Bernal D, Redondo-Muñoz J, Dios-Esponera A, Chèvre R, Bailón E, Garayoa M, Arellano-Sánchez N, Gutierrez NC, Hidalgo A, García-Pardo A, Teixidó J.

J Pathol. 2013 Jan;229(1):36-48. doi: 10.1002/path.4066.

PMID:
22711564
19.

The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.

Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH.

J Biol Chem. 2014 Jun 20;289(25):17689-98. doi: 10.1074/jbc.M113.536227. Epub 2014 May 1.

20.

Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1.

Parmo-Cabañas M, García-Bernal D, García-Verdugo R, Kremer L, Márquez G, Teixidó J.

J Leukoc Biol. 2007 Aug;82(2):380-91. Epub 2007 May 17.

PMID:
17510295

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