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The transmembrane domain of TACE regulates protein ectodomain shedding.

Li X, Pérez L, Pan Z, Fan H.

Cell Res. 2007 Dec;17(12):985-98.


Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing.

Merlos-Suárez A, Fernández-Larrea J, Reddy P, Baselga J, Arribas J.

J Biol Chem. 1998 Sep 18;273(38):24955-62.


ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha.

Le Gall SM, Bobé P, Reiss K, Horiuchi K, Niu XD, Lundell D, Gibb DR, Conrad D, Saftig P, Blobel CP.

Mol Biol Cell. 2009 Mar;20(6):1785-94. doi: 10.1091/mbc.E08-11-1135. Epub 2009 Jan 21.


TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.

Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF.

Ann N Y Acad Sci. 2003 May;995:22-38. Review.


Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC.

J Biol Chem. 2004 Jun 4;279(23):24179-88. Epub 2004 Apr 5.


[Emerging roles of TACE as a central component of ectodomain shedding in vivo].

Horiuchi K.

Tanpakushitsu Kakusan Koso. 2009 Oct;54(13):1728-34. Review. Japanese. No abstract available.


Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K.

PLoS One. 2013;8(1):e54853. doi: 10.1371/journal.pone.0054853. Epub 2013 Jan 18.


An essential role for ectodomain shedding in mammalian development.

Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA.

Science. 1998 Nov 13;282(5392):1281-4.


Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.

Zhang Z, Oliver P, Lancaster JR Jr, Schwarzenberger PO, Joshi MS, Cork J, Kolls JK.

FASEB J. 2001 Feb;15(2):303-5. Epub 2000 Dec 8.


Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17.

Sahin U, Blobel CP.

FEBS Lett. 2007 Jan 9;581(1):41-4. Epub 2006 Dec 6.


Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.

Canault M, Leroyer AS, Peiretti F, Lesèche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G.

Am J Pathol. 2007 Nov;171(5):1713-23. Epub 2007 Sep 14.


Activation of tumor necrosis factor-alpha-converting enzyme-mediated ectodomain shedding by nitric oxide.

Zhang Z, Kolls JK, Oliver P, Good D, Schwarzenberger PO, Joshi MS, Ponthier JL, Lancaster JR Jr.

J Biol Chem. 2000 May 26;275(21):15839-44.


Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo.

Yoda M, Kimura T, Tohmonda T, Morioka H, Matsumoto M, Okada Y, Toyama Y, Horiuchi K.

PLoS One. 2013;8(1):e54412. doi: 10.1371/journal.pone.0054412. Epub 2013 Jan 14.


Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

Sunnarborg SW, Hinkle CL, Stevenson M, Russell WE, Raska CS, Peschon JJ, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Lee DC.

J Biol Chem. 2002 Apr 12;277(15):12838-45. Epub 2002 Jan 31.

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