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Items: 1 to 20 of 120

1.

Mixed-linkage ubiquitin chains send mixed messages.

Nakasone MA, Livnat-Levanon N, Glickman MH, Cohen RE, Fushman D.

Structure. 2013 May 7;21(5):727-40. doi: 10.1016/j.str.2013.02.019. Epub 2013 Apr 4.

2.

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.

Phu L, Izrael-Tomasevic A, Matsumoto ML, Bustos D, Dynek JN, Fedorova AV, Bakalarski CE, Arnott D, Deshayes K, Dixit VM, Kelley RF, Vucic D, Kirkpatrick DS.

Mol Cell Proteomics. 2011 May;10(5):M110.003756. doi: 10.1074/mcp.M110.003756. Epub 2010 Nov 3.

3.

Characterization of polyubiquitin chain structure by middle-down mass spectrometry.

Xu P, Peng J.

Anal Chem. 2008 May 1;80(9):3438-44. doi: 10.1021/ac800016w. Epub 2008 Mar 20.

4.

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL.

J Biol Chem. 2007 Jun 15;282(24):17375-86. Epub 2007 Apr 10.

5.

Analysis of the biochemical role of Lys-11 in polyubiquitin chain formation using quantitative mass spectrometry.

Jung JW, Bae SJ, Kang GY, Kim KH, Yeo WS, Park SH, Seol JH, Yi EC, Kim KP.

Rapid Commun Mass Spectrom. 2013 Jan 30;27(2):339-46. doi: 10.1002/rcm.6447.

PMID:
23239382
6.

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

Kim HT, Kim KP, Uchiki T, Gygi SP, Goldberg AL.

EMBO J. 2009 Jul 8;28(13):1867-77. doi: 10.1038/emboj.2009.115. Epub 2009 Apr 23.

7.

The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin.

Nguyen L, Plafker KS, Starnes A, Cook M, Klevit RE, Plafker SM.

Biochemistry. 2014 Jun 24;53(24):4004-14. doi: 10.1021/bi500072v. Epub 2014 Jun 13.

8.

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9. doi: 10.1073/pnas.1407849111. Epub 2014 May 27.

9.

Exploring the linkage dependence of polyubiquitin conformations using molecular modeling.

Fushman D, Walker O.

J Mol Biol. 2010 Jan 29;395(4):803-14. doi: 10.1016/j.jmb.2009.10.039. Epub 2009 Oct 22.

10.

Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

Sims JJ, Cohen RE.

Mol Cell. 2009 Mar 27;33(6):775-83. doi: 10.1016/j.molcel.2009.02.011.

11.

Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a.

Kim HT, Goldberg AL.

Methods Mol Biol. 2012;832:639-52. doi: 10.1007/978-1-61779-474-2_45.

PMID:
22350918
12.

A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.

Kristariyanto YA, Abdul Rehman SA, Weidlich S, Knebel A, Kulathu Y.

EMBO Rep. 2017 Mar;18(3):392-402. doi: 10.15252/embr.201643205. Epub 2017 Jan 12.

PMID:
28082312
13.

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.

Castañeda CA, Dixon EK, Walker O, Chaturvedi A, Nakasone MA, Curtis JE, Reed MR, Krueger S, Cropp TA, Fushman D.

Structure. 2016 Mar 1;24(3):423-36. doi: 10.1016/j.str.2016.01.007. Epub 2016 Feb 11.

14.

Simultaneous detection of distinct ubiquitin chain topologies by 19F NMR.

Shekhawat SS, Pham GH, Prabakaran J, Strieter ER.

ACS Chem Biol. 2014 Oct 17;9(10):2229-36. doi: 10.1021/cb500589c. Epub 2014 Aug 22.

15.

Structural and biochemical studies of the open state of Lys48-linked diubiquitin.

Lai MY, Zhang D, Laronde-Leblanc N, Fushman D.

Biochim Biophys Acta. 2012 Nov;1823(11):2046-56. doi: 10.1016/j.bbamcr.2012.04.003. Epub 2012 Apr 16.

16.

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.

Kravtsova-Ivantsiv Y, Sommer T, Ciechanover A.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):192-8. doi: 10.1002/anie.201205656. Epub 2012 Nov 4. Review.

PMID:
23124625
17.

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.

Suryadinata R, Holien JK, Yang G, Parker MW, Papaleo E, Šarčević B.

Cell Cycle. 2013 Jun 1;12(11):1732-44. doi: 10.4161/cc.24818. Epub 2013 May 8.

18.

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

Michel MA, Elliott PR, Swatek KN, Simicek M, Pruneda JN, Wagstaff JL, Freund SM, Komander D.

Mol Cell. 2015 Apr 2;58(1):95-109. doi: 10.1016/j.molcel.2015.01.042. Epub 2015 Mar 5.

19.

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling.

Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K.

Mol Cell. 2016 Oct 20;64(2):251-266. doi: 10.1016/j.molcel.2016.09.014. Epub 2016 Oct 13.

PMID:
27746020
20.

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes.

McGouran JF, Gaertner SR, Altun M, Kramer HB, Kessler BM.

Chem Biol. 2013 Dec 19;20(12):1447-55. doi: 10.1016/j.chembiol.2013.10.012. Epub 2013 Nov 27.

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