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Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy.

Erlandson KM, Allshouse AA, Jankowski CM, Lee EJ, Rufner KM, Palmer BE, Wilson CC, MaWhinney S, Kohrt WM, Campbell TB.

J Infect Dis. 2013 Jul 15;208(2):249-59. doi: 10.1093/infdis/jit147. Epub 2013 Apr 4.


The role of extended-release niacin on immune activation and neurocognition in HIV-infected patients treated with antiretroviral therapy - CTN PT006: study protocol for a randomized controlled trial.

Lebouché B, Jenabian MA, Singer J, Graziani GM, Engler K, Trottier B, Thomas R, Brouillette MJ, Routy JP.

Trials. 2014 Oct 7;15:390. doi: 10.1186/1745-6215-15-390.


HIV-1-specific cytolytic T-lymphocyte activity correlates with lower viral load, higher CD4 count, and CD8+CD38-DR- phenotype: comparison of statistical methods for measurement.

Lubaki NM, Shepherd ME, Brookmeyer RS, Hon H, Quinn TC, Kashamuka M, Johnson M, Gottle R, Devers J, Lederman HM, Bollinger RC.

J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):19-30.


Higher Activation in CD4(+) T Cells But Similar Viral Control Among HIV/Hepatitis C Virus-Coinfected Patients on a Simplification Monotherapy.

BenMarzouk-Hidalgo OJ, Torres-Cornejo A, Gutierrez-Valencia A, Ruiz-Valderas R, Viciana P, López-Cortés LF.

AIDS Res Hum Retroviruses. 2016 Jan;32(1):6-11. doi: 10.1089/AID.2014.0299. Epub 2015 Oct 21.


Dominant enrichment of phenotypically activated CD38(+) HLA-DR(+) CD8(+) T cells, rather than CD38(+) HLA-DR(+) CD4(+) T cells, in HIV/HCV coinfected patients on antiretroviral therapy.

d'Ettorre G, Ceccarelli G, Serafino S, Giustini N, Cavallari EN, Bianchi L, Pavone P, Bellelli V, Turriziani O, Antonelli G, Stroffolini T, Vullo V.

J Med Virol. 2016 Aug;88(8):1347-56. doi: 10.1002/jmv.24475. Epub 2016 Jan 20.


Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery.

Massanella M, Negredo E, Puig J, Puertas MC, Buzón MJ, Pérez-Álvarez N, Carrillo J, Clotet B, Martínez-Picado J, Blanco J.

AIDS. 2012 Nov 28;26(18):2285-93. doi: 10.1097/QAD.0b013e328359f20f.


HIV-1-infected children on HAART: immunologic features of three different levels of viral suppression.

Zaccarelli-Filho CA, Ono E, Machado DM, Brunialti M, Succi RC, Salomão R, Kallás EG, de Moraes-Pinto MI.

Cytometry B Clin Cytom. 2007 Jan 15;72(1):14-21.


Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-term antiretroviral therapy.

Zheng L, Taiwo B, Gandhi RT, Hunt PW, Collier AC, Flexner C, Bosch RJ.

J Acquir Immune Defic Syndr. 2014 Oct 1;67(2):153-60. doi: 10.1097/QAI.0000000000000286.


Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy.

Hunt PW, Cao HL, Muzoora C, Ssewanyana I, Bennett J, Emenyonu N, Kembabazi A, Neilands TB, Bangsberg DR, Deeks SG, Martin JN.

AIDS. 2011 Nov 13;25(17):2123-31. doi: 10.1097/QAD.0b013e32834c4ac1.


Lack of correlation between the size of HIV proviral DNA reservoir and the level of immune activation in HIV-infected patients with a sustained undetectable HIV viral load for 10 years.

Poizot-Martin I, Faucher O, Obry-Roguet V, Nicolino-Brunet C, Ronot-Bregigeon S, Dignat-George F, Tamalet C.

J Clin Virol. 2013 Aug;57(4):351-5. doi: 10.1016/j.jcv.2013.04.007. Epub 2013 May 8.


HCV coinfection does not alter the frequency of regulatory T cells or CD8+ T cell immune activation in chronically infected HIV+ Chinese subjects.

Zhuang Y, Wei X, Li Y, Zhao K, Zhang J, Kang W, Sun Y.

AIDS Res Hum Retroviruses. 2012 Sep;28(9):1044-51. doi: 10.1089/AID.2011.0318. Epub 2012 Mar 2.


Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.

Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR.

J Infect Dis. 2017 Mar 15;215(6):911-919. doi: 10.1093/infdis/jix039.


Role of in vitro stimulation with lipopolysaccharide on T-cell activation in HIV-infected antiretroviral-treated patients.

Tincati C, Bellistrì GM, Ancona G, Merlini E, d'Arminio Monforte A, Marchetti G.

Clin Dev Immunol. 2012;2012:935425. doi: 10.1155/2012/935425. Epub 2012 Feb 15.


Assessment of CD8 T cell immune activation markers to monitor response to antiretroviral therapy among HIV-1 infected patients in Côte d'Ivoire.

Ondoa P, Koblavi-Dème S, Borget MY, Nolan ML, Nkengasong JN, Kestens L.

Clin Exp Immunol. 2005 Apr;140(1):138-48.


Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy.

Leung V, Gillis J, Raboud J, Cooper C, Hogg RS, Loutfy MR, Machouf N, Montaner JS, Rourke SB, Tsoukas C, Klein MB; CANOC Collaboration.

PLoS One. 2013 Oct 30;8(10):e77665. doi: 10.1371/journal.pone.0077665. eCollection 2013.


CD8+ T-cell activation in HIV-1-infected patients experiencing transient low-level viremia during antiretroviral therapy.

Taiwo B, Hunt PW, Gandhi RT, Ellingson A, McKenna M, Jacobson JM, Gripshover B, Bosch RJ.

J Acquir Immune Defic Syndr. 2013 May 1;63(1):101-4. doi: 10.1097/QAI.0b013e3182895af4.


Cd38 expression on Cd8+ T cells in Human immunodeficiency virus 1-positive adults treated with HAART.

Beran O, Holub M, Spála J, Kalanin J, Stanková M.

Acta Virol. 2003;47(2):121-4.


Immune reconstitution in HIV+ subjects on lopinavir/ritonavir-based HAART according to the severity of pre-therapy CD4+.

Marchetti G, Merlini E, Sinigaglia E, Iannotti N, Bai F, Savoldi A, Tincati C, Carpani G, Bini T, Arminio Monforte A.

Curr HIV Res. 2012 Oct;10(7):597-605.


Dysfunctional phenotypes of CD4+ and CD8+ T cells are comparable in patients initiating ART during early or chronic HIV-1 infection.

Amu S, Lantto Graham R, Bekele Y, Nasi A, Bengtsson C, Rethi B, Sorial S, Meini G, Zazzi M, Hejdeman B, Chiodi F.

Medicine (Baltimore). 2016 Jun;95(23):e3738. doi: 10.1097/MD.0000000000003738.

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