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Abelson interactor 1 (ABI1) and its interaction with Wiskott-Aldrich syndrome protein (wasp) are critical for proper eye formation in Xenopus embryos.

Singh A, Winterbottom EF, Ji YJ, Hwang YS, Daar IO.

J Biol Chem. 2013 May 17;288(20):14135-46. doi: 10.1074/jbc.M112.445643. Epub 2013 Apr 4.


Regulation of actin cytoskeleton architecture by Eps8 and Abi1.

Roffers-Agarwal J, Xanthos JB, Miller JR.

BMC Cell Biol. 2005 Oct 14;6:36.


Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction.

Wang T, Cleary RA, Wang R, Tang DD.

J Biol Chem. 2013 Jul 12;288(28):20713-22. doi: 10.1074/jbc.M112.439877. Epub 2013 Jun 5.


Essential role for Abi1 in embryonic survival and WAVE2 complex integrity.

Dubielecka PM, Ladwein KI, Xiong X, Migeotte I, Chorzalska A, Anderson KV, Sawicki JA, Rottner K, Stradal TE, Kotula L.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7. doi: 10.1073/pnas.1016811108. Epub 2011 Apr 11.


Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.

Innocenti M, Gerboth S, Rottner K, Lai FP, Hertzog M, Stradal TE, Frittoli E, Didry D, Polo S, Disanza A, Benesch S, Di Fiore PP, Carlier MF, Scita G.

Nat Cell Biol. 2005 Oct;7(10):969-76. Epub 2005 Sep 11.


Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics.

Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M.

Mol Cell Biol. 2012 Aug;32(15):3153-63. doi: 10.1128/MCB.00161-12. Epub 2012 Jun 4.


Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development.

Wu J, O'Donnell M, Gitler AD, Klein PS.

Development. 2006 Sep;133(18):3651-60. Epub 2006 Aug 16.


A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages.

Kheir WA, Gevrey JC, Yamaguchi H, Isaac B, Cox D.

J Cell Sci. 2005 Nov 15;118(Pt 22):5369-79.


Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.

Ring C, Ginsberg MH, Haling J, Pendergast AM.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):149-54. doi: 10.1073/pnas.1012316108. Epub 2010 Dec 20.


Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP.

Park J, Sung JY, Park J, Song WJ, Chang S, Chung KC.

J Cell Sci. 2012 Jan 1;125(Pt 1):67-80. doi: 10.1242/jcs.086124. Epub 2012 Jan 16.


WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.

Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.

J Biol Chem. 2014 Dec 12;289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23.


PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.

Côté JF, Chung PL, Théberge JF, Hallé M, Spencer S, Lasky LA, Tremblay ML.

J Biol Chem. 2002 Jan 25;277(4):2973-86. Epub 2001 Nov 15.


Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G.

Nat Cell Biol. 2004 Apr;6(4):319-27. Epub 2004 Mar 28.


Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT.

J Biol Chem. 2002 Aug 2;277(31):28238-46. Epub 2002 May 23.


A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS.

J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6.


Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness.

Hu J, Mukhopadhyay A, Craig AW.

J Biol Chem. 2011 Jan 21;286(3):2261-72. doi: 10.1074/jbc.M110.157974. Epub 2010 Nov 9.


The chemotactic defect in wiskott-Aldrich syndrome macrophages is due to the reduced persistence of directional protrusions.

Ishihara D, Dovas A, Park H, Isaac BM, Cox D.

PLoS One. 2012;7(1):e30033. doi: 10.1371/journal.pone.0030033. Epub 2012 Jan 18.

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