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Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization.

Evdokimov K, Biswas S, Adrian M, Weber J, Schledzewski K, Winkler M, Goerdt S, Géraud C.

Biochem Biophys Res Commun. 2013 Apr 26;434(1):22-7. doi: 10.1016/j.bbrc.2013.03.073.


Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.

Biswas S, Adrian M, Weber J, Evdokimov K, Winkler M, Géraud C.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):661-6. doi: 10.1016/j.bbrc.2016.06.116.


Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages.

Biswas S, Adrian M, Evdokimov K, Schledzewski K, Weber J, Winkler M, Goerdt S, Géraud C.

Biochem Biophys Res Commun. 2015 Sep 4;464(4):1078-83. doi: 10.1016/j.bbrc.2015.07.079.


Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing.

Evdokimov K, Biswas S, Schledzewski K, Winkler M, Gorzelanny C, Schneider SW, Goerdt S, Géraud C.

Biochem Biophys Res Commun. 2016 Jul 8;475(4):342-9. doi: 10.1016/j.bbrc.2016.05.092.


Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.

Guo HF, Li X, Parker MW, Waltenberger J, Becker PM, Vander Kooi CW.

Biochemistry. 2013 Oct 29;52(43):7551-8. doi: 10.1021/bi401034q.


O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids.

Schjoldager KT, Vester-Christensen MB, Bennett EP, Levery SB, Schwientek T, Yin W, Blixt O, Clausen H.

J Biol Chem. 2010 Nov 19;285(47):36293-303. doi: 10.1074/jbc.M110.156950.


Proprotein convertases process and thereby inactivate formylglycine-generating enzyme.

Ennemann EC, Radhakrishnan K, Mariappan M, Wachs M, Pringle TH, Schmidt B, Dierks T.

J Biol Chem. 2013 Feb 22;288(8):5828-39. doi: 10.1074/jbc.M112.405159.


Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.

Kato S, Zhang R, Roberts JD Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L130-40. doi: 10.1152/ajplung.00391.2012.


Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D.

J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618.


Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, Chrétien M, Calvo F, Seidah NG, Khatib AM.

Gut. 2008 Nov;57(11):1573-82. doi: 10.1136/gut.2007.141812.


Tissue distribution and processing of proSAAS by proprotein convertases.

Sayah M, Fortenberry Y, Cameron A, Lindberg I.

J Neurochem. 2001 Mar;76(6):1833-41.


Characterization and expression of proprotein convertases in CHO cells: Efficient proteolytic maturation of human bone morphogenetic protein-7.

Sathyamurthy M, Kim CL, Bang YL, Kim YS, Jang JW, Lee GM.

Biotechnol Bioeng. 2015 Mar;112(3):560-8. doi: 10.1002/bit.25458.


The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG.

J Biol Chem. 2008 Jan 25;283(4):2373-84.


The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).

Kara I, Poggi M, Bonardo B, Govers R, Landrier JF, Tian S, Leibiger I, Day R, Creemers JW, Peiretti F.

J Biol Chem. 2015 Jan 30;290(5):2812-21. doi: 10.1074/jbc.M114.592543.


Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.

Munck Petersen C, Nielsen MS, Jacobsen C, Tauris J, Jacobsen L, Gliemann J, Moestrup SK, Madsen P.

EMBO J. 1999 Feb 1;18(3):595-604.


Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

Stawowy P, Kallisch H, Borges Pereira Stawowy N, Stibenz D, Veinot JP, Gräfe M, Seidah NG, Chrétien M, Fleck E, Graf K.

Virchows Arch. 2005 Apr;446(4):351-9.


Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules.

Komiyama T, Coppola JM, Larsen MJ, van Dort ME, Ross BD, Day R, Rehemtulla A, Fuller RS.

J Biol Chem. 2009 Jun 5;284(23):15729-38. doi: 10.1074/jbc.M901540200.


Furin processing dictates ectodomain shedding of human FAT1 cadherin.

Sadeqzadeh E, de Bock CE, Wojtalewicz N, Holt JE, Smith ND, Dun MD, Schwarte-Waldhoff I, Thorne RF.

Exp Cell Res. 2014 Apr 15;323(1):41-55. doi: 10.1016/j.yexcr.2014.02.012.

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