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Items: 1 to 20 of 149

1.

Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury.

Eid AA, Ford BM, Bhandary B, de Cassia Cavaglieri R, Block K, Barnes JL, Gorin Y, Choudhury GG, Abboud HE.

Diabetes. 2013 Aug;62(8):2935-47. doi: 10.2337/db12-1504. Epub 2013 Apr 4.

2.

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.

Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, Rashid A, Moodad S, Block K, Gorin Y, Abboud HE, Eid AA.

Antioxid Redox Signal. 2016 Nov 1;25(13):703-719. Epub 2016 Sep 12.

3.

AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes.

Eid AA, Ford BM, Block K, Kasinath BS, Gorin Y, Ghosh-Choudhury G, Barnes JL, Abboud HE.

J Biol Chem. 2010 Nov 26;285(48):37503-12. doi: 10.1074/jbc.M110.136796. Epub 2010 Sep 22.

4.

Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis.

Das R, Xu S, Nguyen TT, Quan X, Choi SK, Kim SJ, Lee EY, Cha SK, Park KS.

J Biol Chem. 2015 Dec 25;290(52):30830-42. doi: 10.1074/jbc.M115.703116. Epub 2015 Nov 12.

5.

Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.

Gorin Y, Cavaglieri RC, Khazim K, Lee DY, Bruno F, Thakur S, Fanti P, Szyndralewiez C, Barnes JL, Block K, Abboud HE.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014. Epub 2015 Feb 4.

6.
7.

The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.

Khazim K, Gorin Y, Cavaglieri RC, Abboud HE, Fanti P.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700. doi: 10.1152/ajprenal.00028.2013. Epub 2013 Jun 26.

8.

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway.

Miao XY, Gu ZY, Liu P, Hu Y, Li L, Gong YP, Shu H, Liu Y, Li CL.

Peptides. 2013 Jan;39:71-9. doi: 10.1016/j.peptides.2012.10.006. Epub 2012 Oct 30.

PMID:
23116613
9.

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.

Jha JC, Thallas-Bonke V, Banal C, Gray SP, Chow BS, Ramm G, Quaggin SE, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

Diabetologia. 2016 Feb;59(2):379-89. doi: 10.1007/s00125-015-3796-0. Epub 2015 Oct 28.

PMID:
26508318
10.

Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.

Sedeek M, Callera G, Montezano A, Gutsol A, Heitz F, Szyndralewiez C, Page P, Kennedy CR, Burns KD, Touyz RM, Hébert RL.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1348-58. doi: 10.1152/ajprenal.00028.2010. Epub 2010 Jul 14.

11.

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes.

Jin Y, Liu S, Ma Q, Xiao D, Chen L.

Eur J Pharmacol. 2017 Jan 5;794:106-114. doi: 10.1016/j.ejphar.2016.11.037. Epub 2016 Nov 22.

PMID:
27887947
12.

Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions.

Langer S, Kreutz R, Eisenreich A.

J Nephrol. 2016 Dec;29(6):765-773. Epub 2016 Jan 5.

PMID:
26733332
13.

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE.

Diabetes. 2009 May;58(5):1201-11. doi: 10.2337/db08-1536. Epub 2009 Feb 10.

14.

Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase.

Sauer H, Engel S, Milosevic N, Sharifpanah F, Wartenberg M.

Int J Oncol. 2012 Feb;40(2):501-8. doi: 10.3892/ijo.2011.1230. Epub 2011 Oct 13.

PMID:
22002081
15.

Smad3/Nox4-mediated mitochondrial dysfunction plays a crucial role in puromycin aminonucleoside-induced podocyte damage.

Yu L, Liu Y, Wu Y, Liu Q, Feng J, Gu X, Xiong Y, Fan Q, Ye J.

Cell Signal. 2014 Dec;26(12):2979-91. doi: 10.1016/j.cellsig.2014.08.030. Epub 2014 Sep 16.

PMID:
25229402
16.

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.

You YH, Quach T, Saito R, Pham J, Sharma K.

J Am Soc Nephrol. 2016 Feb;27(2):466-81. doi: 10.1681/ASN.2015030302. Epub 2015 Jul 22.

17.
18.

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.

Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.

Biochim Biophys Acta. 2014 Jul;1842(7):1097-108. doi: 10.1016/j.bbadis.2014.04.001. Epub 2014 Apr 13.

19.

Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways.

Padmasekar M, Sharifpanah F, Finkensieper A, Wartenberg M, Sauer H.

Stem Cells Dev. 2011 Dec;20(12):2163-75. doi: 10.1089/scd.2010.0581. Epub 2011 Apr 6.

PMID:
21470048
20.

Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway.

Huang G, Zou B, Lv J, Li T, Huai G, Xiang S, Lu S, Luo H, Zhang Y, Jin Y, Wang Y.

Int J Mol Med. 2017 Mar;39(3):559-568. doi: 10.3892/ijmm.2017.2864. Epub 2017 Jan 20.

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