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Items: 1 to 20 of 89

1.

Potent agonists of a hematopoietic stem cell cytokine receptor, c-Mpl.

Tarasova A, Haylock DN, Meagher L, Be CL, White J, Nilsson SK, Andrade J, Cartledge K, Winkler DA.

ChemMedChem. 2013 May;8(5):763-71. doi: 10.1002/cmdc.201300089. Epub 2013 Mar 28.

PMID:
23554275
2.

The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis.

Nogami W, Yoshida H, Koizumi K, Yamada H, Abe K, Arimura A, Yamane N, Takahashi K, Yamane A, Oda A, Tanaka Y, Takemoto H, Ohnishi Y, Ikeda Y, Miyakawa Y.

Haematologica. 2008 Oct;93(10):1495-504. doi: 10.3324/haematol.12752. Epub 2008 Aug 25.

3.

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets.

Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, et al.

Blood. 1995 Jan 15;85(2):391-401.

4.
5.

An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis.

Deng B, Banu N, Malloy B, Hass P, Wang JF, Cavacini L, Eaton D, Avraham H.

Blood. 1998 Sep 15;92(6):1981-8.

6.

Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways.

Doshi PD, Giri JG, Abegg AL, Favara JP, Huynh MS, Kahn LE, Minnerly JC, Pegg LE, Villani-Price D, Siegel NR, Staten NR, Thomas JW, McKearn JP, Smith WG.

Exp Hematol. 2001 Oct;29(10):1177-84.

PMID:
11602319
7.

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.

Exp Hematol. 2009 Nov;37(11):1364-1377.e4. doi: 10.1016/j.exphem.2009.09.001. Epub 2009 Sep 8.

PMID:
19744539
8.

Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.

Luoh SM, Stefanich E, Solar G, Steinmetz H, Lipari T, Pestina TI, Jackson CW, de Sauvage FJ.

Mol Cell Biol. 2000 Jan;20(2):507-15.

9.

Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets.

Majka M, Ratajczak J, Villaire G, Kubiczek K, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ.

Exp Hematol. 2002 Jul;30(7):751-60.

PMID:
12135673
10.

Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine.

Cwirla SE, Balasubramanian P, Duffin DJ, Wagstrom CR, Gates CM, Singer SC, Davis AM, Tansik RL, Mattheakis LC, Boytos CM, Schatz PJ, Baccanari DP, Wrighton NC, Barrett RW, Dower WJ.

Science. 1997 Jun 13;276(5319):1696-9.

11.

Role of thrombopoietin in hematopoietic stem cell and progenitor regulation.

Drachman JG.

Curr Opin Hematol. 2000 May;7(3):183-90. Review.

PMID:
10786657
12.
13.

Role of c-mpl in early hematopoiesis.

Solar GP, Kerr WG, Zeigler FC, Hess D, Donahue C, de Sauvage FJ, Eaton DL.

Blood. 1998 Jul 1;92(1):4-10.

14.

Embryonic stem cell differentiation to hematopoietic cells: A model to study the function of various regions of the intracytoplasmic domain of cytokine receptors in vitro.

Filippi MD, Porteu F, Le Pesteur F, Rameau P, Nogueira MM, Debili N, Vainchenker W, de Sauvage FJ, Kupperschmitt AD, Sainteny F.

Exp Hematol. 2000 Dec;28(12):1363-72.

PMID:
11146158
15.

Molecular detection of c-mpl thrombopoietin receptor gene expression in chronic myeloproliferative disorders.

Duensing S, Duensing A, Meran JG, Kreft A, B├╝sche G, Ganser A, Georgii A.

Mol Pathol. 1999 Jun;52(3):146-50.

16.

Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes.

Hofmann WK, Kalina U, Wagner S, Seipelt G, Ries C, Hoelzer D, Ottmann OG.

Exp Hematol. 1999 Mar;27(3):395-400.

PMID:
10089900
17.

Ectopic overexpression of c-mpl by retroviral-mediated gene transfer suppressed megakaryopoiesis but enhanced erythropoiesis in mice.

Yan XQ, Lacey DL, Saris C, Mu S, Hill D, Hawley RG, Fletcher FA.

Exp Hematol. 1999 Sep;27(9):1409-17.

PMID:
10480432
18.

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.

Alexander WS, Roberts AW, Maurer AB, Nicola NA, Dunn AR, Metcalf D.

Stem Cells. 1996;14 Suppl 1:124-32. Review.

20.

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