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Items: 1 to 20 of 123

1.

Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.

Shin DS, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2013 Jun 15;304(12):C1159-67. doi: 10.1152/ajpcell.00353.2012. Epub 2013 Apr 3.

2.
3.

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.

Najmi M, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C150-7. doi: 10.1152/ajpcell.00084.2016. Epub 2016 Jun 1.

4.

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).

Visentin M, Unal ES, Najmi M, Fiser A, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C631-41. doi: 10.1152/ajpcell.00238.2014. Epub 2015 Jan 21.

5.

Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.

Shin DS, Zhao R, Fiser A, Goldman DI.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C834-42. doi: 10.1152/ajpcell.00171.2012. Epub 2012 Jul 25.

6.

Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).

Zhao R, Shin DS, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 Sep 15;303(6):C673-81. doi: 10.1152/ajpcell.00123.2012. Epub 2012 Jul 11.

7.

Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.

Zhao R, Shin DS, Goldman ID.

Biochim Biophys Acta. 2011 Apr;1808(4):1140-5. doi: 10.1016/j.bbamem.2011.01.008. Epub 2011 Jan 20.

8.

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.

Zhao R, Najmi M, Fiser A, Goldman ID.

J Biol Chem. 2016 Apr 8;291(15):8162-72. doi: 10.1074/jbc.M115.693929. Epub 2016 Feb 16.

9.

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.

Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1405-12. doi: 10.1152/ajpcell.00435.2011. Epub 2012 Feb 15.

10.

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.

Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1153-61. doi: 10.1152/ajpcell.00113.2010. Epub 2010 Aug 4.

11.

Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.

Zhao R, Unal ES, Shin DS, Goldman ID.

Biochemistry. 2010 Apr 6;49(13):2925-31. doi: 10.1021/bi9021439.

12.

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.

Aluri S, Zhao R, Fiser A, Goldman ID.

Biochim Biophys Acta. 2017 Aug 9;1859(11):2193-2202. doi: 10.1016/j.bbamem.2017.08.006. [Epub ahead of print]

PMID:
28802835
13.

The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Chang MH, Fiser A, Romero MF, Goldman ID.

J Biol Chem. 2009 Jun 26;284(26):17846-57. doi: 10.1074/jbc.M109.008060. Epub 2009 Apr 23.

14.

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.

Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID.

Blood. 2010 Dec 9;116(24):5162-9. doi: 10.1182/blood-2010-06-291237. Epub 2010 Aug 30.

15.

Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.

Wilson MR, Hou Z, Wilson LJ, Ye J, Matherly LH.

Biochem J. 2016 Oct 15;473(20):3545-3562. Epub 2016 Aug 11.

16.

A novel deletion mutation in the proton-coupled folate transporter (PCFT; SLC46A1) in a Nicaraguan child with hereditary folate malabsorption.

Diop-Bove N, Jain M, Scaglia F, Goldman ID.

Gene. 2013 Sep 25;527(2):673-4. doi: 10.1016/j.gene.2013.06.039. Epub 2013 Jun 28.

17.

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C66-74. doi: 10.1152/ajpcell.00096.2009. Epub 2009 Apr 29.

18.

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. Epub 2007 Sep 26.

19.

The proton-coupled folate transporter: physiological and pharmacological roles.

Zhao R, Goldman ID.

Curr Opin Pharmacol. 2013 Dec;13(6):875-80. Review.

20.

Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.

Hou Z, Matherly LH.

Curr Top Membr. 2014;73:175-204. doi: 10.1016/B978-0-12-800223-0.00004-9. Review.

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