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Items: 1 to 20 of 183

1.

Potential role for human P-glycoprotein in the transport of lacosamide.

Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L.

Epilepsia. 2013 Jul;54(7):1154-60. doi: 10.1111/epi.12158. Epub 2013 Mar 29.

2.

In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.

Chan PS, Zhang C, Zuo Z, Kwan P, Baum L.

Epilepsy Res. 2014 Mar;108(3):359-66. doi: 10.1016/j.eplepsyres.2014.01.011. Epub 2014 Jan 30.

PMID:
24530088
3.

Several major antiepileptic drugs are substrates for human P-glycoprotein.

Luna-Tortós C, Fedrowitz M, Löscher W.

Neuropharmacology. 2008 Dec;55(8):1364-75. doi: 10.1016/j.neuropharm.2008.08.032. Epub 2008 Sep 11.

PMID:
18824002
4.

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.

Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Löscher W.

Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10.

PMID:
17045309
5.

In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein.

Zhang C, Kwan P, Zuo Z, Baum L.

Life Sci. 2010 Jun 5;86(23-24):899-905. doi: 10.1016/j.lfs.2010.04.008. Epub 2010 Apr 24.

PMID:
20417647
6.

In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein.

Zhang C, Zuo Z, Kwan P, Baum L.

Epilepsia. 2011 Oct;52(10):1894-904. doi: 10.1111/j.1528-1167.2011.03140.x. Epub 2011 Jun 21.

7.

Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected.

Löscher W, Luna-Tortós C, Römermann K, Fedrowitz M.

Curr Pharm Des. 2011;17(26):2808-28. Review.

PMID:
21827408
8.

The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2).

Römermann K, Helmer R, Löscher W.

Neuropharmacology. 2015 Jun;93:7-14. doi: 10.1016/j.neuropharm.2015.01.015. Epub 2015 Jan 31.

PMID:
25645391
9.

Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.

Cao J, Chen X, Liang J, Yu XQ, Xu AL, Chan E, Wei D, Huang M, Wen JY, Yu XY, Li XT, Sheu FS, Zhou SF.

Drug Metab Dispos. 2007 Apr;35(4):539-53. Epub 2007 Jan 12.

10.

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF.

J Pharmacol Exp Ther. 2000 May;293(2):376-82.

11.

P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.

Fujimoto H, Higuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H.

Biol Pharm Bull. 2009 Sep;32(9):1588-93.

13.

Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.

van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD.

Eur J Pharm Sci. 2000 Sep;11(3):207-14.

PMID:
11042226
14.

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Liu PQ, Duan W, Chowbay B, Wen JY, Li CG, Zhou SF.

Curr Drug Metab. 2007 May;8(4):325-40.

PMID:
17504222
15.

Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport.

Kuteykin-Teplyakov K, Luna-Tortós C, Ambroziak K, Löscher W.

Br J Pharmacol. 2010 Jul;160(6):1453-63. doi: 10.1111/j.1476-5381.2010.00801.x.

16.

Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

Batrakova EV, Miller DW, Li S, Alakhov VY, Kabanov AV, Elmquist WF.

J Pharmacol Exp Ther. 2001 Feb;296(2):551-7.

17.

Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.

Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K.

Eur J Pharm Sci. 2002 Aug;16(3):159-65.

PMID:
12128170
18.

Carbamazepine is not a substrate for P-glycoprotein.

Owen A, Pirmohamed M, Tettey JN, Morgan P, Chadwick D, Park BK.

Br J Clin Pharmacol. 2001 Apr;51(4):345-9.

19.

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy.

Luna-Tortós C, Fedrowitz M, Löscher W.

Neuropharmacology. 2010 Jun;58(7):1019-32. doi: 10.1016/j.neuropharm.2010.01.007. Epub 2010 Jan 18.

PMID:
20080116
20.

Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines.

Ambroziak K, Kuteykin-Teplyakov K, Luna-Tórtos C, Al-Falah M, Fedrowitz M, Löscher W.

Eur J Pharmacol. 2010 Feb 25;628(1-3):57-66. doi: 10.1016/j.ejphar.2009.11.051. Epub 2009 Dec 1.

PMID:
19958760

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