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Items: 1 to 20 of 143

1.

Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways.

Li Q, Huai L, Zhang C, Wang C, Jia Y, Chen Y, Yu P, Wang H, Rao Q, Wang M, Wang J.

Int J Hematol. 2013 May;97(5):617-23. doi: 10.1007/s12185-013-1317-9.

PMID:
23550021
2.

Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.

Merhi F, Tang R, Piedfer M, Mathieu J, Bombarda I, Zaher M, Kolb JP, Billard C, Bauvois B.

PLoS One. 2011;6(10):e25963. doi: 10.1371/journal.pone.0025963.

3.

Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

Zhu Jf, Li Zj, Zhang Gs, Meng K, Kuang Wy, Li J, Zhou Xf, Li Rj, Peng Hl, Dai Cw, Shen JK, Gong Fj, Xu Yx, Liu Sf.

PLoS One. 2011;6(8):e23720. doi: 10.1371/journal.pone.0023720.

4.

Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.

Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60.

PMID:
17341418
5.

Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells.

Mise J, Dembitz V, Banfic H, Visnjic D.

Pathol Oncol Res. 2011 Sep;17(3):645-56. doi: 10.1007/s12253-011-9365-z.

PMID:
21336564
6.

Anti-leukemic effect of 2-pyrone derivatives via MAPK and PI3 kinase pathways.

Yoon JS, Won YW, Kim SJ, Oh SJ, Kim ES, Kim BK, Cho CG, Choi JH, Park BB, Lee MH, Lee YY.

Invest New Drugs. 2012 Dec;30(6):2284-93. doi: 10.1007/s10637-012-9814-x.

PMID:
22526834
7.

Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced lung cancer cell apoptosis.

Zhou L, Luan H, Liu Q, Jiang T, Liang H, Dong X, Shang H.

Mol Med Rep. 2012 May;5(5):1256-60. doi: 10.3892/mmr.2012.798.

PMID:
22367396
8.

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.

Papa V, Tazzari PL, Chiarini F, Cappellini A, Ricci F, Billi AM, Evangelisti C, Ottaviani E, Martinelli G, Testoni N, McCubrey JA, Martelli AM.

Leukemia. 2008 Jan;22(1):147-60.

PMID:
17928881
9.

PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma.

Das S, Dey KK, Bharti R, MaitiChoudhury S, Maiti S, Mandal M.

J Exp Ther Oncol. 2012;10(2):139-53.

PMID:
23350354
11.
12.

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts.

Lunghi P, Tabilio A, Dall'Aglio PP, Ridolo E, Carlo-Stella C, Pelicci PG, Bonati A.

Leukemia. 2003 Sep;17(9):1783-93.

PMID:
12970778
13.

SYK regulates mTOR signaling in AML.

Carnevale J, Ross L, Puissant A, Banerji V, Stone RM, DeAngelo DJ, Ross KN, Stegmaier K.

Leukemia. 2013 Nov;27(11):2118-28. doi: 10.1038/leu.2013.89.

14.

Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma.

Wu T, Wang S, Wu J, Lin Z, Sui X, Xu X, Shimizu N, Chen B, Wang X.

J Exp Clin Cancer Res. 2015 Feb 15;34:17. doi: 10.1186/s13046-015-0133-x.

15.
16.

Active lipids of Ganoderma lucidum spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K pathways.

Wang JH, Zhou YJ, Zhang M, Kan L, He P.

J Ethnopharmacol. 2012 Jan 31;139(2):582-9. doi: 10.1016/j.jep.2011.11.055.

PMID:
22172327
17.

β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.

Zhan YH, Liu J, Qu XJ, Hou KZ, Wang KF, Liu YP, Wu B.

Asian Pac J Cancer Prev. 2012;13(6):2739-44.

18.
19.

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody.

Chapuis N, Tamburini J, Cornillet-Lefebvre P, Gillot L, Bardet V, Willems L, Park S, Green AS, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D.

Haematologica. 2010 Mar;95(3):415-23. doi: 10.3324/haematol.2009.010785.

20.

Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.

Rao J, Xu DR, Zheng FM, Long ZJ, Huang SS, Wu X, Zhou WH, Huang RW, Liu Q.

J Transl Med. 2011 May 19;9:71. doi: 10.1186/1479-5876-9-71.

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