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CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.

Huang S, Guo S, Guo F, Yang Q, Xiao X, Murata M, Ohnishi S, Kawanishi S, Ma N.

Eur J Histochem. 2013 Jan 14;57(1):e1. doi: 10.4081/ejh.2013.e1.


Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.

Sun Y, Pi J, Wang X, Tokar EJ, Liu J, Waalkes MP.

Toxicology. 2009 Aug 3;262(2):162-70. doi: 10.1016/j.tox.2009.06.003. Epub 2009 Jun 12.


Malignant transformation of immortalized HaCaT keratinocytes through deregulated nuclear factor kappaB signaling.

Ren Q, Kari C, Quadros MR, Burd R, McCue P, Dicker AP, Rodeck U.

Cancer Res. 2006 May 15;66(10):5209-15.


The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-κB.

Jiang R, Li Y, Zhang A, Wang B, Xu Y, Xu W, Zhao Y, Luo F, Liu Q.

Toxicol Lett. 2014 Jun 5;227(2):91-8. doi: 10.1016/j.toxlet.2014.03.020. Epub 2014 Apr 2.


[Dynamic changes of ROS, MDA and SOD during arsenic-induced neoplastic transformation in human keratinocytes].

Ma Y, Wang D, Xu X, Yang X, Wang X, Zhu Z, Zhao Y, Chen M, Xu F, Fu L, Zhu J, Gao F, An Y.

Wei Sheng Yan Jiu. 2015 May;44(3):456-61. Chinese.


The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.

Li Y, Ling M, Xu Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Toxicol Sci. 2010 Jul;116(1):174-82. doi: 10.1093/toxsci/kfq109. Epub 2010 Apr 7.


EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.

Jiang R, Li Y, Xu Y, Zhou Y, Pang Y, Shen L, Zhao Y, Zhang J, Zhou J, Wang X, Liu Q.

Arch Toxicol. 2013 Jun;87(6):991-1000. doi: 10.1007/s00204-012-0933-0. Epub 2012 Oct 16.


Association of chromosomal alterations with arsenite-induced tumorigenicity of human HaCaT keratinocytes in nude mice.

Chien CW, Chiang MC, Ho IC, Lee TC.

Environ Health Perspect. 2004 Dec;112(17):1704-10.


Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.

Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP.

Free Radic Biol Med. 2008 Sep 1;45(5):651-8. doi: 10.1016/j.freeradbiomed.2008.05.020. Epub 2008 Jun 3.


Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.

Trouba KJ, Geisenhoffer KM, Germolec DR.

Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6.


Requirement of arsenic biomethylation for oxidative DNA damage.

Kojima C, Ramirez DC, Tokar EJ, Himeno S, Drobná Z, Stýblo M, Mason RP, Waalkes MP.

J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81. doi: 10.1093/jnci/djp414.


Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

Sun Y, Tokar EJ, Waalkes MP.

Toxicol Sci. 2012 Jan;125(1):20-9. doi: 10.1093/toxsci/kfr282. Epub 2011 Oct 19.


Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes.

Li Y, Jiang R, Zhao Y, Xu Y, Ling M, Pang Y, Shen L, Zhou Y, Zhang J, Zhou J, Wang X, Liu Q.

Toxicology. 2012 Oct 28;300(3):121-31. doi: 10.1016/j.tox.2012.06.004. Epub 2012 Jun 15.


Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation.

Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP.

Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8.


Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.

Kumasaka MY, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S, Khalequzzaman M, Shekhar HU, Nakajima T, Kato M.

Arch Toxicol. 2013 Mar;87(3):439-47. doi: 10.1007/s00204-012-0964-6. Epub 2012 Oct 26.


mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells.

Li Y, Xu Y, Ling M, Yang Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Environ Health Perspect. 2010 Jul;118(7):936-42. doi: 10.1289/ehp.0901677. Epub 2010 Mar 3.


Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype.

Tokar EJ, Diwan BA, Waalkes MP.

Environ Health Perspect. 2010 Jan;118(1):108-15. doi: 10.1289/ehp.0901059.


PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.

Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C.

Environ Health Perspect. 2008 Jan;116(1):1-6. doi: 10.1289/ehp.10403.


Opposing roles for calcineurin and ATF3 in squamous skin cancer.

Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP.

Nature. 2010 May 20;465(7296):368-72. doi: 10.1038/nature08996.


Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer.

Shah P, Trinh E, Qiang L, Xie L, Hu WY, Prins GS, Pi J, He YY.

Molecules. 2017 Jan 24;22(2). pii: E194. doi: 10.3390/molecules22020194.

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