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Aneuploidy in health, disease, and aging.

Ricke RM, van Deursen JM.

J Cell Biol. 2013 Apr 1;201(1):11-21. doi: 10.1083/jcb.201301061. Review.


BubR1 kinase: protection against aneuploidy and premature aging.

Kapanidou M, Lee S, Bolanos-Garcia VM.

Trends Mol Med. 2015 Jun;21(6):364-72. doi: 10.1016/j.molmed.2015.04.003. Epub 2015 May 8. Review.


Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM.

Nat Cell Biol. 2013 Jan;15(1):96-102. doi: 10.1038/ncb2643. Epub 2012 Dec 16.


How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models.

Lee H.

Mol Cells. 2014 Oct 31;37(10):713-8. doi: 10.14348/molcells.2014.0233. Epub 2014 Sep 26. Review.


The mitotic checkpoint in cancer and aging: what have mice taught us?

Baker DJ, Chen J, van Deursen JM.

Curr Opin Cell Biol. 2005 Dec;17(6):583-9. Epub 2005 Oct 13. Review.


Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.

Ricke RM, Jeganathan KB, van Deursen JM.

J Cell Biol. 2011 Jun 13;193(6):1049-64. doi: 10.1083/jcb.201012035. Epub 2011 Jun 6.


BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.


New insights into the role of BubR1 in mitosis and beyond.

Karess RE, Wassmann K, Rahmani Z.

Int Rev Cell Mol Biol. 2013;306:223-73. doi: 10.1016/B978-0-12-407694-5.00006-7. Review.


Mitotic Dysfunction Associated with Aging Hallmarks.

Macedo JC, Vaz S, Logarinho E.

Adv Exp Med Biol. 2017;1002:153-188. doi: 10.1007/978-3-319-57127-0_7. Review.


Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH.

Aging Cell. 2017 Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6.


BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM.

Nat Genet. 2004 Jul;36(7):744-9. Epub 2004 Jun 20.


Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

Suijkerbuijk SJ, van Osch MH, Bos FL, Hanks S, Rahman N, Kops GJ.

Cancer Res. 2010 Jun 15;70(12):4891-900. doi: 10.1158/0008-5472.CAN-09-4319. Epub 2010 Jun 1.


ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability.

Cheng X, Shen Z, Yang J, Lu SH, Cui Y.

J Biol Chem. 2008 Feb 29;283(9):5888-98. Epub 2007 Dec 27.


Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis.

Li JJ, Li SA.

Pharmacol Ther. 2006 Sep;111(3):974-84. Epub 2006 Apr 17. Review.


Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM.

PLoS Genet. 2012;8(12):e1003138. doi: 10.1371/journal.pgen.1003138. Epub 2012 Dec 27.


Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.

Rao CV, Yamada HY, Yao Y, Dai W.

Carcinogenesis. 2009 Sep;30(9):1469-74. doi: 10.1093/carcin/bgp081. Epub 2009 Apr 16. Review.


Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

Liu Q, Hirohashi Y, Du X, Greene MI, Wang Q.

Exp Mol Pathol. 2010 Apr;88(2):225-33. doi: 10.1016/j.yexmp.2009.12.004. Epub 2009 Dec 23.


Targeting the mitotic checkpoint to kill tumor cells.

Janssen A, Kops GJ, Medema RH.

Horm Cancer. 2011 Apr;2(2):113-6. doi: 10.1007/s12672-010-0059-x. Epub 2010 Dec 17.


Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice.

Andriani GA, Faggioli F, Baker D, Dollé ME, Sellers RS, Hébert JM, Van Steeg H, Hoeijmakers J, Vijg J, Montagna C.

Hum Mol Genet. 2016 Feb 15;25(4):755-65. doi: 10.1093/hmg/ddv612. Epub 2015 Dec 17.


Preventing aneuploidy: the contribution of mitotic checkpoint proteins.

Suijkerbuijk SJ, Kops GJ.

Biochim Biophys Acta. 2008 Sep;1786(1):24-31. doi: 10.1016/j.bbcan.2008.04.001. Epub 2008 Apr 22. Review.


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