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Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

van der Post S, Subramani DB, Bäckström M, Johansson ME, Vester-Christensen MB, Mandel U, Bennett EP, Clausen H, Dahlén G, Sroka A, Potempa J, Hansson GC.

J Biol Chem. 2013 May 17;288(20):14636-46. doi: 10.1074/jbc.M113.459479. Epub 2013 Apr 1.


Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.

Lidell ME, Moncada DM, Chadee K, Hansson GC.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9298-303. Epub 2006 Jun 5.


Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50.

Rangarajan M, Hashim A, Aduse-Opoku J, Paramonov N, Hounsell EF, Curtis MA.

Infect Immun. 2005 Aug;73(8):4864-78.


Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.

Subramani DB, Johansson ME, Dahlén G, Hansson GC.

Benef Microbes. 2010 Nov;1(4):343-50. doi: 10.3920/BM2010.0039.


Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins.

Johansson ME.

PLoS One. 2012;7(7):e41009. doi: 10.1371/journal.pone.0041009. Epub 2012 Jul 17.


Multiple enzyme approach for the characterization of glycan modifications on the C-terminus of the intestinal MUC2mucin.

van der Post S, Thomsson KA, Hansson GC.

J Proteome Res. 2014 Dec 5;13(12):6013-23. doi: 10.1021/pr500874f. Epub 2014 Nov 25.


Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage.

Kantyka T, Latendorf T, Wiedow O, Bartels J, Gläser R, Dubin G, Schröder JM, Potempa J, Meyer-Hoffert U.

Biol Chem. 2009 Dec;390(12):1313-20. doi: 10.1515/BC.2009.136.


Reversible redox regulation of specificity of Arg-gingipain B in Porphyromonas gingivalis.

Chen YY, Seers CA, Slakeski N, Moore C, Zhang L, Reynolds EC.

FEBS Lett. 2013 May 2;587(9):1275-80. doi: 10.1016/j.febslet.2013.02.051. Epub 2013 Mar 13.


Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis.

Zhou XY, Gao JL, Hunter N, Potempa J, Nguyen KA.

Mol Microbiol. 2013 Sep;89(5):903-17. doi: 10.1111/mmi.12319. Epub 2013 Jul 19.


Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases.

Arike L, Holmén-Larsson J, Hansson GC.

Glycobiology. 2017 Apr 1;27(4):318-328. doi: 10.1093/glycob/cww134.


Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.


Cleavage of the human C5A receptor by proteinases derived from Porphyromonas gingivalis: cleavage of leukocyte C5a receptor.

Jagels MA, Ember JA, Travis J, Potempa J, Pike R, Hugli TE.

Adv Exp Med Biol. 1996;389:155-64.


The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

Godl K, Johansson ME, Lidell ME, Mörgelin M, Karlsson H, Olson FJ, Gum JR Jr, Kim YS, Hansson GC.

J Biol Chem. 2002 Dec 6;277(49):47248-56. Epub 2002 Oct 8.


Generation of lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.

Aduse-Opoku J, Davies NN, Gallagher A, Hashim A, Evans HE, Rangarajan M, Slaney JM, Curtis MA.

Microbiology. 2000 Aug;146 ( Pt 8):1933-40.


Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis.

Skottrup PD, Leonard P, Kaczmarek JZ, Veillard F, Enghild JJ, O'Kennedy R, Sroka A, Clausen RP, Potempa J, Riise E.

Anal Biochem. 2011 Aug 15;415(2):158-67. doi: 10.1016/j.ab.2011.04.015. Epub 2011 Apr 20.


Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes.

Ally N, Whisstock JC, Sieprawska-Lupa M, Potempa J, Le Bonniec BF, Travis J, Pike RN.

Biochemistry. 2003 Oct 14;42(40):11693-700.


The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria.

Arike L, Hansson GC.

J Mol Biol. 2016 Aug 14;428(16):3221-3229. doi: 10.1016/j.jmb.2016.02.010. Epub 2016 Feb 12. Review.


The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.

Lidell ME, Johansson ME, Mörgelin M, Asker N, Gum JR Jr, Kim YS, Hansson GC.

Biochem J. 2003 Jun 1;372(Pt 2):335-45.

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