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Alzheimer's phenotypes induced by overexpression of human presenilin 2 mutant proteins stimulate significant changes in key factors of glucose metabolism.

Lee YJ, Kim JE, Hwang IS, Kwak MH, Lee JH, Jung YJ, An BS, Kwon HS, Kim BC, Kim SJ, Kim JM, Hwang DY.

Mol Med Rep. 2013 May;7(5):1571-8. doi: 10.3892/mmr.2013.1404. Epub 2013 Mar 28.


Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.

Hwang DY, Chae KR, Kang TS, Hwang JH, Lim CH, Kang HK, Goo JS, Lee MR, Lim HJ, Min SH, Cho JY, Hong JT, Song CW, Paik SG, Cho JS, Kim YK.

FASEB J. 2002 Jun;16(8):805-13.


Aβ-42 deposition significantly increases the insolubility of synaptophysin in the brains of hAPPsw/hPS2m double transgenic mice.

Hwang DY, Jee SW, Lee SH, Bae CJ, Goo JS, Kim JE, Nam SH, Choi SI, Lee HR, Shim SB, Park MH, Hong JT, Kim HS.

Int J Mol Med. 2011 Aug;28(2):223-9. doi: 10.3892/ijmm.2011.673. Epub 2011 Apr 13.


Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice.

Chua LM, Lim ML, Chong PR, Hu ZP, Cheung NS, Wong BS.

J Alzheimers Dis. 2012;29(4):783-91. doi: 10.3233/JAD-2012-111880.


Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model.

Um HS, Kang EB, Leem YH, Cho IH, Yang CH, Chae KR, Hwang DY, Cho JY.

Int J Mol Med. 2008 Oct;22(4):529-39.


Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw.

Hwang DY, Cho JS, Oh JH, Shim SB, Jee SW, Lee SH, Seo SJ, Song CW, Lee SH, Kim YK.

Cell Mol Neurobiol. 2005 Aug;25(5):881-98.


Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.

Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J.

J Biol Chem. 2011 May 27;286(21):18414-25. doi: 10.1074/jbc.M110.209718. Epub 2011 Apr 1.


Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice.

Yun WB, Park JJ, Kim JE, Sung JE, Lee HA, Lee JH, Bae CJ, Hwang DY.

Lab Anim Res. 2016 Dec;32(4):249-256. doi: 10.5625/lar.2016.32.4.249. Epub 2016 Dec 23.


Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.

Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T.

J Biol Chem. 2012 Oct 12;287(42):35222-33. doi: 10.1074/jbc.M112.348300. Epub 2012 Aug 21.


Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.

Dobarro M, Gerenu G, Ramírez MJ.

Int J Neuropsychopharmacol. 2013 Nov;16(10):2245-57. doi: 10.1017/S1461145713000631. Epub 2013 Jun 17.


Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.

Hiltunen M, Khandelwal VK, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H.

J Cell Mol Med. 2012 Jun;16(6):1206-22. doi: 10.1111/j.1582-4934.2011.01384.x.


Illite improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer׳s disease through Akt/CREB and GSK-3β phosphorylation in the brain.

Jeon S, Park JE, Lee J, Liu QF, Jeong HJ, Pak SC, Yi S, Kim MH, Kim CW, Park JK, Kim GW, Koo BS.

J Ethnopharmacol. 2015 Feb 3;160:69-77. doi: 10.1016/j.jep.2014.11.029. Epub 2014 Nov 29.


Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.

Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM.

FASEB J. 2004 May;18(7):902-4. Epub 2004 Mar 19.


FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation.

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.

PLoS One. 2013 Nov 4;8(11):e78033. doi: 10.1371/journal.pone.0078033. eCollection 2013.


Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice.

Hwang DY, Cho JS, Kim CK, Shim SB, Jee SW, Lee SH, Seo SJ, Cho JY, Lee SH, Kim YK.

Neurochem Res. 2005 Sep;30(9):1171-7.


Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice.

Fang F, Chen D, Yu P, Qian W, Zhou J, Liu J, Gao R, Wang J, Xiao H.

Gen Comp Endocrinol. 2015 Feb 1;212:44-50. doi: 10.1016/j.ygcen.2015.01.017. Epub 2015 Jan 28.


Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin.

Jolivalt CG, Lee CA, Beiswenger KK, Smith JL, Orlov M, Torrance MA, Masliah E.

J Neurosci Res. 2008 Nov 15;86(15):3265-74. doi: 10.1002/jnr.21787.

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