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Items: 1 to 20 of 95

1.

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.

2.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.

3.

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM.

J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036.

4.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.

J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.

5.

Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.

Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR.

J Neurosci Res. 2014 Oct;92(10):1307-18. doi: 10.1002/jnr.23402. Epub 2014 May 7.

6.

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.

Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ.

Exp Neurol. 2001 Aug;170(2):227-43.

PMID:
11476589
7.

Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.

Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q.

Neurotoxicology. 2014 Dec;45:81-90. doi: 10.1016/j.neuro.2014.09.005. Epub 2014 Sep 30.

8.

Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.

Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE.

Ann Neurol. 2009 Mar;65(3):294-303. doi: 10.1002/ana.21578.

9.

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM.

Hum Mol Genet. 2016 Nov 15;25(22):4920-4938. doi: 10.1093/hmg/ddw316.

10.

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Shi J, Longo FM, Massa SM.

Stem Cells. 2013 Nov;31(11):2561-74. doi: 10.1002/stem.1516.

11.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.

PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.

12.

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

McClean PL, Parthsarathy V, Faivre E, Hölscher C.

J Neurosci. 2011 Apr 27;31(17):6587-94. doi: 10.1523/JNEUROSCI.0529-11.2011.

13.

Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor.

Sotthibundhu A, Sykes AM, Fox B, Underwood CK, Thangnipon W, Coulson EJ.

J Neurosci. 2008 Apr 9;28(15):3941-6. doi: 10.1523/JNEUROSCI.0350-08.2008.

14.

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice.

Liu MY, Wang S, Yao WF, Zhang ZJ, Zhong X, Sha L, He M, Zheng ZH, Wei MJ.

Neuroscience. 2014 Jul 25;273:141-51. doi: 10.1016/j.neuroscience.2014.05.011. Epub 2014 May 15.

PMID:
24846616
15.

[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.

James ML, Belichenko NP, Shuhendler AJ, Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg W, Rao J, Gambhir SS, Longo FM.

Theranostics. 2017 Mar 24;7(6):1422-1436. doi: 10.7150/thno.17666. eCollection 2017.

16.

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.

Murphy M, Wilson YM, Vargas E, Munro KM, Smith B, Huang A, Li QX, Xiao J, Masters CL, Reid CA, Barrett GL.

Neurobiol Aging. 2015 Feb;36(2):740-52. doi: 10.1016/j.neurobiolaging.2014.09.014. Epub 2014 Sep 28.

PMID:
25443284
17.

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.

J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

18.

Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration.

Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF.

Brain Res. 2014 Jan 16;1543:253-62. doi: 10.1016/j.brainres.2013.10.055. Epub 2013 Nov 11.

PMID:
24231553
19.

Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice.

Chakravarthy B, Gaudet C, Ménard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J.

J Alzheimers Dis. 2010;19(3):915-25. doi: 10.3233/JAD-2010-1288.

PMID:
20157247
20.

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.

Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, Huang X, Xiong W, Ren C, Liu XG, Chui D, Liu G.

Mol Brain. 2014 Sep 13;7:65. doi: 10.1186/s13041-014-0065-y.

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