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Items: 1 to 20 of 121

1.

Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2.

Engström Ruud L, Wilhelms DB, Eskilsson A, Vasilache AM, Elander L, Engblom D, Blomqvist A.

Neuropharmacology. 2013 Aug;71:124-9. doi: 10.1016/j.neuropharm.2013.03.012. Epub 2013 Mar 29.

PMID:
23545161
2.

Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge.

Elander L, Engström L, Ruud J, Mackerlova L, Jakobsson PJ, Engblom D, Nilsberth C, Blomqvist A.

J Neurosci. 2009 Feb 4;29(5):1404-13. doi: 10.1523/JNEUROSCI.5247-08.2009.

3.

c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1).

Dallaporta M, Pecchi E, Jacques C, Berenbaum F, Jean A, Thirion S, Troadec JD.

Brain Behav Immun. 2007 Nov;21(8):1109-21. Epub 2007 Jul 2.

PMID:
17604949
4.

Involvement of central microsomal prostaglandin E synthase-1 in IL-1beta-induced anorexia.

Pecchi E, Dallaporta M, Thirion S, Salvat C, Berenbaum F, Jean A, Troadec JD.

Physiol Genomics. 2006 May 16;25(3):485-92. Epub 2006 Mar 22.

PMID:
16554545
5.

Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever.

Wilhelms DB, Kirilov M, Mirrasekhian E, Eskilsson A, Kugelberg UÖ, Klar C, Ridder DA, Herschman HR, Schwaninger M, Blomqvist A, Engblom D.

J Neurosci. 2014 Aug 27;34(35):11684-90. doi: 10.1523/JNEUROSCI.1838-14.2014.

6.

Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells.

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A.

Endocrinology. 2012 Oct;153(10):4849-61. Epub 2012 Aug 7.

PMID:
22872578
7.

Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1.

Nilsberth C, Hamzic N, Norell M, Blomqvist A.

J Neuroendocrinol. 2009 Aug;21(8):715-21. doi: 10.1111/j.1365-2826.2009.01888.x. Epub 2009 Jun 4.

PMID:
19500218
8.

Arsenic reduces the antipyretic activity of paracetamol in rats: modulation of brain COX-2 activity and CB₁ receptor expression.

Vijayakaran K, Kannan K, Kesavan M, Suresh S, Sankar P, Tandan SK, Sarkar SN.

Environ Toxicol Pharmacol. 2014 Jan;37(1):438-47. doi: 10.1016/j.etap.2013.12.015. Epub 2014 Jan 2.

PMID:
24448467
9.

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.

Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y.

Br J Pharmacol. 2010 Mar;159(5):1174-86. doi: 10.1111/j.1476-5381.2009.00595.x. Epub 2010 Jan 29.

10.

Prostaglandin E2 as a mediator of fever: synthesis and catabolism.

Ivanov AI, Romanovsky AA.

Front Biosci. 2004 May 1;9:1977-93. Review.

PMID:
14977603
11.

Cyclooxygenase-2/microsomal prostaglandin E synthase-1 complex in the preoptic-anterior hypothalamus of the mouse: involvement through fever to intravenous lipopolysaccharide.

Gaetano L, Watanabe K, Barogi S, Coceani F.

Acta Physiol (Oxf). 2010 Dec;200(4):315-24. doi: 10.1111/j.1748-1716.2010.02157.x.

PMID:
20587000
12.

MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.

Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D.

J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4.

13.

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A.

Nat Neurosci. 2003 Nov;6(11):1137-8. Epub 2003 Oct 19.

14.

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.

Sasaki Y, Kamiyama S, Kamiyama A, Matsumoto K, Akatsu M, Nakatani Y, Kuwata H, Ishikawa Y, Ishii T, Yokoyama C, Hara S.

Sci Rep. 2015 Nov 27;5:17376. doi: 10.1038/srep17376.

15.

The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.

Nilsberth C, Elander L, Hamzic N, Norell M, Lönn J, Engström L, Blomqvist A.

Endocrinology. 2009 Apr;150(4):1850-60. doi: 10.1210/en.2008-0806. Epub 2008 Nov 20.

PMID:
19022895
16.

Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.

Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y.

J Neurochem. 2005 Sep;94(6):1546-58. Epub 2005 Jul 5.

17.

Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.

Ayoub SS, Botting RM, Goorha S, Colville-Nash PR, Willoughby DA, Ballou LR.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11165-9. Epub 2004 Jul 19.

18.

Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.

Simmons DL, Wagner D, Westover K.

Clin Infect Dis. 2000 Oct;31 Suppl 5:S211-8. Review.

PMID:
11113025
19.

Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages.

Díaz-Muñoz MD, Osma-García IC, Cacheiro-Llaguno C, Fresno M, Iñiguez MA.

Cell Signal. 2010 Oct;22(10):1427-36. doi: 10.1016/j.cellsig.2010.05.011. Epub 2010 May 21.

PMID:
20546888
20.

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.

Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh CD, Zhang DD, Henke M, Weigert A, Brüne B, Rubin B, Nusing R, Scholich K, Geisslinger G.

J Biol Chem. 2011 Jan 21;286(3):2331-42. doi: 10.1074/jbc.M110.157362. Epub 2010 Nov 12.

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