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Items: 1 to 20 of 82

1.

Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects.

Harlan SM, Guo DF, Morgan DA, Fernandes-Santos C, Rahmouni K.

Cell Metab. 2013 Apr 2;17(4):599-606.

2.

The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice.

Muta K, Morgan DA, Rahmouni K.

Endocrinology. 2015 Apr;156(4):1398-407. doi: 10.1210/en.2014-1660. Epub 2015 Jan 9.

3.

Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.

Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG Jr.

Endocrinology. 2009 Oct;150(10):4541-51. doi: 10.1210/en.2009-0642. Epub 2009 Jul 23.

4.

Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.

Palaniappan M, Menon B, Menon KM.

Mol Cell Endocrinol. 2013 Feb 5;366(1):81-9. doi: 10.1016/j.mce.2012.12.004. Epub 2012 Dec 19.

5.

The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E229-36. doi: 10.1152/ajpendo.00409.2012. Epub 2012 Nov 27.

6.

mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.

Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr, Gao T, Evers BM.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. doi: 10.1152/ajpcell.00067.2011. Epub 2011 Apr 20.

7.

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC.

Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1.

8.

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.

Watterson KR, Bestow D, Gallagher J, Hamilton DL, Ashford FB, Meakin PJ, Ashford ML.

Neurosignals. 2013;21(1-2):28-41. doi: 10.1159/000334144. Epub 2012 Mar 28.

9.

Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.

Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K.

J Neurosci. 2015 Jan 14;35(2):474-84. doi: 10.1523/JNEUROSCI.1828-14.2015.

10.

ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation.

Parrales A, López E, Lee-Rivera I, López-Colomé AM.

Cell Signal. 2013 Apr;25(4):829-38. doi: 10.1016/j.cellsig.2012.12.023. Epub 2013 Jan 3.

PMID:
23291002
11.

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.

PMID:
24793303
12.

Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle.

Hsieh CT, Chuang JH, Yang WC, Yin Y, Lin Y.

Cell Signal. 2014 Jul;26(7):1400-8. doi: 10.1016/j.cellsig.2014.03.004. Epub 2014 Mar 17.

PMID:
24650522
13.

Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation.

Tanida M, Yamamoto N, Shibamoto T, Rahmouni K.

PLoS One. 2013;8(2):e56660. doi: 10.1371/journal.pone.0056660. Epub 2013 Feb 13.

14.

Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits.

Prior LJ, Eikelis N, Armitage JA, Davern PJ, Burke SL, Montani JP, Barzel B, Head GA.

Hypertension. 2010 Apr;55(4):862-8. doi: 10.1161/HYPERTENSIONAHA.109.141119. Epub 2010 Mar 1.

15.

Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo.

Werzowa J, Koehrer S, Strommer S, Cejka D, Fuereder T, Zebedin E, Wacheck V.

J Invest Dermatol. 2011 Feb;131(2):495-503. doi: 10.1038/jid.2010.327. Epub 2010 Nov 4.

16.

Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Fan QW, Weiss WA.

Methods Mol Biol. 2012;821:349-59. doi: 10.1007/978-1-61779-430-8_22.

17.

Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.

Shan J, Nguyen TB, Totary-Jain H, Dansky H, Marx SO, Marks AR.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):19006-11. doi: 10.1073/pnas.0809743105. Epub 2008 Nov 19.

18.
19.

Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc.

Szewczyk B, Pochwat B, Rafało A, Palucha-Poniewiera A, Domin H, Nowak G.

Neuropharmacology. 2015 Dec;99:517-26. doi: 10.1016/j.neuropharm.2015.08.026. Epub 2015 Aug 19.

PMID:
26297535
20.

Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles.

Kellenberger AJ, Tauchi M.

Exp Dermatol. 2013 Jan;22(1):77-80. doi: 10.1111/exd.12062.

PMID:
23278901

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