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Items: 1 to 20 of 91

1.

Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.

Liu Y, Richardson J, Tran T, Al-Muhtasib N, Xie T, Yenugonda VM, Sexton HG, Rezvani AH, Levin ED, Sahibzada N, Kellar KJ, Brown ML, Xiao Y, Paige M.

J Med Chem. 2013 Apr 11;56(7):3000-11. doi: 10.1021/jm4000374. Epub 2013 Apr 1.

2.

Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

Rezvani AH, Slade S, Wells C, Petro A, Lumeng L, Li TK, Xiao Y, Brown ML, Paige MA, McDowell BE, Rose JE, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2010 Aug;211(2):161-74. doi: 10.1007/s00213-010-1878-8. Epub 2010 Jun 10.

4.

Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.

Liu Y, Paige M, Olson TT, Al-Muhtasib N, Xie T, Hou S, White MP, Cordova A, Guo JL, Kellar KJ, Xiao Y, Brown ML.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2954-6. doi: 10.1016/j.bmcl.2014.04.036. Epub 2014 Apr 23.

PMID:
24844195
5.

Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain.

Hussmann GP, DeDominicis KE, Turner JR, Yasuda RP, Klehm J, Forcelli PA, Xiao Y, Richardson JR, Sahibzada N, Wolfe BB, Lindstrom J, Blendy JA, Kellar KJ.

J Neurochem. 2014 May;129(4):721-31. doi: 10.1111/jnc.12653. Epub 2014 Feb 7.

6.

Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

Hussmann GP, Turner JR, Lomazzo E, Venkatesh R, Cousins V, Xiao Y, Yasuda RP, Wolfe BB, Perry DC, Rezvani AH, Levin ED, Blendy JA, Kellar KJ.

J Pharmacol Exp Ther. 2012 Nov;343(2):441-50. doi: 10.1124/jpet.112.198085. Epub 2012 Aug 16.

7.

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T.

J Med Chem. 2002 Jul 18;45(15):3235-45.

PMID:
12109907
8.

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.

Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12518-23. Epub 2007 Jul 11.

9.

Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.

Rezvani AH, Timofeeva O, Sexton HG, DeCuir D, Xiao Y, Gordon CJ, Kellar KJ, Levin ED.

Eur J Pharmacol. 2012 May 5;682(1-3):110-7. doi: 10.1016/j.ejphar.2012.02.031. Epub 2012 Feb 24.

10.

Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.

Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ.

Mol Pharmacol. 2006 Oct;70(4):1454-60. Epub 2006 Jul 20.

11.

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors.

Zwart R, Carbone AL, Moroni M, Bermudez I, Mogg AJ, Folly EA, Broad LM, Williams AC, Zhang D, Ding C, Heinz BA, Sher E.

Mol Pharmacol. 2008 Jun;73(6):1838-43. doi: 10.1124/mol.108.045104. Epub 2008 Mar 26.

12.

Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.

Kamens HM, Andersen J, Picciotto MR.

Psychopharmacology (Berl). 2010 Mar;208(4):613-26. doi: 10.1007/s00213-009-1759-1.

13.

The high-affinity nAChR partial agonists varenicline and sazetidine-A exhibit reinforcing properties in rats.

Paterson NE, Min W, Hackett A, Lowe D, Hanania T, Caldarone B, Ghavami A.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1455-64. doi: 10.1016/j.pnpbp.2010.07.037. Epub 2010 Aug 11.

PMID:
20708056
14.

Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats.

Chatterjee S, Steensland P, Simms JA, Holgate J, Coe JW, Hurst RS, Shaffer CL, Lowe J, Rollema H, Bartlett SE.

Neuropsychopharmacology. 2011 Feb;36(3):603-15. doi: 10.1038/npp.2010.191. Epub 2010 Nov 3.

15.

Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression.

Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, He R, Caldarone B, Manzano M, Yuen PW, Lukas RJ.

ChemMedChem. 2009 Aug;4(8):1279-91. doi: 10.1002/cmdc.200900079.

16.

Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.

Rezvani AH, Cauley M, Sexton H, Xiao Y, Brown ML, Paige MA, McDowell BE, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2011 Jun;215(4):621-30. doi: 10.1007/s00213-010-2161-8. Epub 2011 Jan 28.

PMID:
21274704
17.

Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.

Yenugonda VM, Xiao Y, Levin ED, Rezvani AH, Tran T, Al-Muhtasib N, Sahibzada N, Xie T, Wells C, Slade S, Johnson JE, Dakshanamurthy S, Kong HS, Tomita Y, Liu Y, Paige M, Kellar KJ, Brown ML.

J Med Chem. 2013 Nov 14;56(21):8404-21. doi: 10.1021/jm4008455. Epub 2013 Oct 18.

PMID:
24047231
18.

Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice.

Sajja RK, Rahman S.

Pharmacol Biochem Behav. 2012 Jul;102(1):36-43. Epub 2012 Mar 27.

PMID:
22741175
19.
20.

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.

Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE, Kellar KJ.

J Pharmacol Exp Ther. 2010 Mar;332(3):933-9. doi: 10.1124/jpet.109.162073. Epub 2009 Dec 10.

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