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Items: 1 to 20 of 92

1.

Regulation of phenylalanine hydroxylase: conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry.

Li J, Fitzpatrick PF.

Arch Biochem Biophys. 2013 Jul 15;535(2):115-9. doi: 10.1016/j.abb.2013.03.006. Epub 2013 Mar 26.

2.
4.

Structural basis of autoregulation of phenylalanine hydroxylase.

Kobe B, Jennings IG, House CM, Michell BJ, Goodwill KE, Santarsiero BD, Stevens RC, Cotton RG, Kemp BE.

Nat Struct Biol. 1999 May;6(5):442-8.

PMID:
10331871
5.

Identification by hydrogen/deuterium exchange of structural changes in tyrosine hydroxylase associated with regulation.

Wang S, Sura GR, Dangott LJ, Fitzpatrick PF.

Biochemistry. 2009 Jun 9;48(22):4972-9. doi: 10.1021/bi9004254.

6.

Phenylalanine binding is linked to dimerization of the regulatory domain of phenylalanine hydroxylase.

Zhang S, Roberts KM, Fitzpatrick PF.

Biochemistry. 2014 Oct 28;53(42):6625-7. doi: 10.1021/bi501109s. Epub 2014 Oct 13.

7.

Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase.

Horne J, Jennings IG, Teh T, Gooley PR, Kobe B.

Protein Sci. 2002 Aug;11(8):2041-7.

8.

Allosteric regulation of phenylalanine hydroxylase.

Fitzpatrick PF.

Arch Biochem Biophys. 2012 Mar 15;519(2):194-201. doi: 10.1016/j.abb.2011.09.012. Epub 2011 Oct 7. Review.

9.

Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase.

Li J, Ilangovan U, Daubner SC, Hinck AP, Fitzpatrick PF.

Arch Biochem Biophys. 2011 Jan 15;505(2):250-5. doi: 10.1016/j.abb.2010.10.009. Epub 2010 Oct 14.

10.

Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications.

Flydal MI, Mohn TC, Pey AL, Siltberg-Liberles J, Teigen K, Martinez A.

Amino Acids. 2010 Nov;39(5):1463-75. doi: 10.1007/s00726-010-0611-6. Epub 2010 May 18.

PMID:
20480196
11.

Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site.

Roberts KM, Khan CA, Hinck CS, Fitzpatrick PF.

Biochemistry. 2014 Dec 16;53(49):7846-53. doi: 10.1021/bi501183x. Epub 2014 Dec 2.

12.

The aromatic amino acid hydroxylases.

Fitzpatrick PF.

Adv Enzymol Relat Areas Mol Biol. 2000;74:235-94. Review.

PMID:
10800597
13.

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

Thórólfsson M, Ibarra-Molero B, Fojan P, Petersen SB, Sanchez-Ruiz JM, Martínez A.

Biochemistry. 2002 Jun 18;41(24):7573-85.

PMID:
12056888
14.

Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron.

Kinzie SD, Thevis M, Ngo K, Whitelegge J, Loo JA, Abu-Omar MM.

J Am Chem Soc. 2003 Apr 23;125(16):4710-1.

PMID:
12696880
15.

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers.

Zhang S, Hinck AP, Fitzpatrick PF.

Biochemistry. 2015 Aug 25;54(33):5167-74. doi: 10.1021/acs.biochem.5b00616. Epub 2015 Aug 13.

16.

Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase.

Kobe B, Jennings IG, House CM, Feil SC, Michell BJ, Tiganis T, Parker MW, Cotton RG, Kemp BE.

Protein Sci. 1997 Jun;6(6):1352-7.

18.

Recombinant human phenylalanine hydroxylase: novel regulatory and structural properties.

Kowlessur D, Citron BA, Kaufman S.

Arch Biochem Biophys. 1996 Sep 1;333(1):85-95.

PMID:
8806757
19.

Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase.

Kowlessur D, Yang XJ, Kaufman S.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4743-7.

20.

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects.

Miranda FF, Teigen K, Thórólfsson M, Svebak RM, Knappskog PM, Flatmark T, Martínez A.

J Biol Chem. 2002 Oct 25;277(43):40937-43. Epub 2002 Aug 15.

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