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Items: 1 to 20 of 173

1.

Cellular catabolism of the iron-regulatory peptide hormone hepcidin.

Preza GC, Pinon R, Ganz T, Nemeth E.

PLoS One. 2013;8(3):e58934. doi: 10.1371/journal.pone.0058934. Epub 2013 Mar 11.

2.

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.

Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J.

Science. 2004 Dec 17;306(5704):2090-3. Epub 2004 Oct 28.

3.

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.

Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B.

Am J Physiol Cell Physiol. 2014 Mar 1;306(5):C450-9. doi: 10.1152/ajpcell.00348.2013. Epub 2013 Dec 4.

4.

Functional characterization of fluorescent hepcidin.

Dürrenberger F, Abbate V, Ma Y, Arno MC, Jaiash D, Parmar A, Marshall V, Latunde-Dada GO, Zimmermann T, Senn D, Altermatt P, Manolova V, Hider RC, Bansal SS.

Bioconjug Chem. 2013 Sep 18;24(9):1527-32. doi: 10.1021/bc400121x. Epub 2013 Aug 14.

PMID:
23888876
5.

Impact of D181V and A69T on the function of ferroportin as an iron export pump and hepcidin receptor.

Praschberger R, Schranz M, Griffiths WJ, Baumgartner N, Hermann M, Lomas DJ, Pietrangelo A, Cox TM, Vogel W, Zoller H.

Biochim Biophys Acta. 2014 Sep;1842(9):1406-12. doi: 10.1016/j.bbadis.2014.05.011. Epub 2014 May 21.

6.

The iron-regulatory hormone hepcidin: a possible therapeutic target?

Rochette L, Gudjoncik A, Guenancia C, Zeller M, Cottin Y, Vergely C.

Pharmacol Ther. 2015 Feb;146:35-52. doi: 10.1016/j.pharmthera.2014.09.004. Epub 2014 Sep 7. Review.

PMID:
25205158
7.

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.

Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E.

Cell Metab. 2012 Jun 6;15(6):918-24. doi: 10.1016/j.cmet.2012.03.018.

8.

The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin.

De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J.

Cell Metab. 2011 Nov 2;14(5):635-46. doi: 10.1016/j.cmet.2011.09.008. Epub 2011 Oct 20. Retraction in: Cell Metab. 2012 Jun 6;15(6):927.

9.

The molecular basis of hepcidin-resistant hereditary hemochromatosis.

Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E.

Blood. 2009 Jul 9;114(2):437-43. doi: 10.1182/blood-2008-03-146134. Epub 2009 Apr 21.

10.

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J.

Mol Biol Cell. 2007 Jul;18(7):2569-78. Epub 2007 May 2.

11.

Hepcidin targets ferroportin for degradation in hepatocytes.

Ramey G, Deschemin JC, Durel B, Canonne-Hergaux F, Nicolas G, Vaulont S.

Haematologica. 2010 Mar;95(3):501-4. doi: 10.3324/haematol.2009.014399. Epub 2009 Sep 22.

12.

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin.

Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor JG 6th, Gordeuk VR.

Haematologica. 2013 Mar;98(3):455-63. doi: 10.3324/haematol.2012.066530. Epub 2012 Oct 12.

13.

Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter.

Rice AE, Mendez MJ, Hokanson CA, Rees DC, Björkman PJ.

J Mol Biol. 2009 Feb 27;386(3):717-32. doi: 10.1016/j.jmb.2008.12.063. Epub 2009 Jan 3.

14.

The hepcidin-binding site on ferroportin is evolutionarily conserved.

De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J.

Cell Metab. 2008 Aug;8(2):146-56. doi: 10.1016/j.cmet.2008.07.002. Retraction in: Cell Metab. 2014 Jun 3;19(6):1067.

15.

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis.

Chothe PP, Gnana-Prakasam JP, Ananth S, Martin PM, Kannan R, Hinton DR, Smith SB, Ganapathy V.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):244-9. doi: 10.1016/j.bbrc.2011.01.018. Epub 2011 Jan 8.

16.

Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.

Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ.

Chem Biol. 2011 Mar 25;18(3):336-43. doi: 10.1016/j.chembiol.2010.12.009.

17.

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.

Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T.

Blood. 2006 Jan 1;107(1):328-33. Epub 2005 Sep 1.

18.

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL.

FASEB J. 2016 Feb;30(2):813-23. doi: 10.1096/fj.15-276758. Epub 2015 Oct 27.

PMID:
26506980
19.

The molecular basis of iron overload disorders and iron-linked anemias.

Kaplan J, Ward DM, De Domenico I.

Int J Hematol. 2011 Jan;93(1):14-20. doi: 10.1007/s12185-010-0760-0. Epub 2011 Jan 7. Review.

PMID:
21210258
20.

Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload.

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.

Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007.

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