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Items: 1 to 20 of 96

1.

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.

Tanaka Y, Hipolito CJ, Maturana AD, Ito K, Kuroda T, Higuchi T, Katoh T, Kato HE, Hattori M, Kumazaki K, Tsukazaki T, Ishitani R, Suga H, Nureki O.

Nature. 2013 Apr 11;496(7444):247-51. doi: 10.1038/nature12014. Epub 2013 Mar 27.

PMID:
23535598
2.

Mechanisms for Two-Step Proton Transfer Reactions in the Outward-Facing Form of MATE Transporter.

Nishima W, Mizukami W, Tanaka Y, Ishitani R, Nureki O, Sugita Y.

Biophys J. 2016 Mar 29;110(6):1346-54. doi: 10.1016/j.bpj.2016.01.027.

3.

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter.

Lu M, Symersky J, Radchenko M, Koide A, Guo Y, Nie R, Koide S.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2099-104. doi: 10.1073/pnas.1219901110. Epub 2013 Jan 22.

4.

A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter.

Hipolito CJ, Tanaka Y, Katoh T, Nureki O, Suga H.

Molecules. 2013 Aug 30;18(9):10514-30. doi: 10.3390/molecules180910514.

5.

Structure and mechanism of a Na+-independent amino acid transporter.

Shaffer PL, Goehring A, Shankaranarayanan A, Gouaux E.

Science. 2009 Aug 21;325(5943):1010-4. doi: 10.1126/science.1176088. Epub 2009 Jul 16.

6.

Structure of a cation-bound multidrug and toxic compound extrusion transporter.

He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G.

Nature. 2010 Oct 21;467(7318):991-4. doi: 10.1038/nature09408. Epub 2010 Sep 22.

7.

Structure determination of fibrillarin from the hyperthermophilic archaeon Pyrococcus furiosus.

Deng L, Starostina NG, Liu ZJ, Rose JP, Terns RM, Terns MP, Wang BC.

Biochem Biophys Res Commun. 2004 Mar 12;315(3):726-32.

PMID:
14975761
8.

Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications.

Lu M.

Channels (Austin). 2016;10(2):88-100. doi: 10.1080/19336950.2015.1106654. Epub 2015 Oct 21. Review.

9.

Structural insights into H+-coupled multidrug extrusion by a MATE transporter.

Lu M, Radchenko M, Symersky J, Nie R, Guo Y.

Nat Struct Mol Biol. 2013 Nov;20(11):1310-7. doi: 10.1038/nsmb.2687. Epub 2013 Oct 20.

10.

Insights into conformational regulation of PfMATE transporter from Pyrococcus furiosus induced by alternating protonation state of Asp41 residue: A molecular dynamics simulation study.

Jin X, Shao Y, Bai Q, Xue W, Liu H, Yao X.

Biochim Biophys Acta. 2016 Jun;1860(6):1173-80. doi: 10.1016/j.bbagen.2016.02.007. Epub 2016 Feb 12.

PMID:
26879959
11.

The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion binding from atomistic molecular dynamics simulations.

Leung YM, Holdbrook DA, Piggot TJ, Khalid S.

Biophys J. 2014 Jul 15;107(2):460-468. doi: 10.1016/j.bpj.2014.06.005.

12.

Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus.

Leonard PM, Smits SH, Sedelnikova SE, Brinkman AB, de Vos WM, van der Oost J, Rice DW, Rafferty JB.

EMBO J. 2001 Mar 1;20(5):990-7.

13.

Identification of novel natural inhibitor for NorM - a multidrug and toxic compound extrusion transporter - an insilico molecular modeling and simulation studies.

Kesherwani M, Michael Gromiha M, Fukui K, Velmurugan D.

J Biomol Struct Dyn. 2017 Jan;35(1):58-77. doi: 10.1080/07391102.2015.1132391. Epub 2016 May 20.

PMID:
26786386
14.

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.

Omote H, Hiasa M, Matsumoto T, Otsuka M, Moriyama Y.

Trends Pharmacol Sci. 2006 Nov;27(11):587-93. Epub 2006 Sep 25.

PMID:
16996621
15.

Structural basis for the blockade of MATE multidrug efflux pumps.

Radchenko M, Symersky J, Nie R, Lu M.

Nat Commun. 2015 Aug 6;6:7995. doi: 10.1038/ncomms8995.

16.

Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors.

Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O.

Methods Mol Biol. 2018;1700:37-57. doi: 10.1007/978-1-4939-7454-2_3.

PMID:
29177824
17.

Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family.

Han BG, Jeong KC, Cho JW, Jeong BC, Song HK, Lee JY, Shin DH, Lee S, Lee BI.

FEBS Lett. 2012 May 7;586(9):1384-8. doi: 10.1016/j.febslet.2012.04.004. Epub 2012 Apr 13.

18.

Crystal structure of the archaeal heat shock regulator from Pyrococcus furiosus: a molecular chimera representing eukaryal and bacterial features.

Liu W, Vierke G, Wenke AK, Thomm M, Ladenstein R.

J Mol Biol. 2007 Jun 1;369(2):474-88. Epub 2007 Mar 24.

PMID:
17434531
19.

Atomic structure of the clamp loader small subunit from Pyrococcus furiosus.

Oyama T, Ishino Y, Cann IK, Ishino S, Morikawa K.

Mol Cell. 2001 Aug;8(2):455-63.

20.

A solution NMR molecular model for the aspartate-ligated, cubane cluster containing ferredoxin from the hyperthermophilic archeaon Pyrococcus furiosus.

Sham S, Calzolai L, Wang PL, Bren K, Haarklau H, Brereton PS, Adams MW, La Mar GN.

Biochemistry. 2002 Oct 15;41(41):12498-508.

PMID:
12369841

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