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UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development.

Hegarty JM, Yang H, Chi NC.

Development. 2013 Apr;140(8):1713-9. doi: 10.1242/dev.093112.


Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.

Nakagawa K, Sawada N, Hirota Y, Uchino Y, Suhara Y, Hasegawa T, Amizuka N, Okamoto T, Tsugawa N, Kamao M, Funahashi N, Okano T.

PLoS One. 2014 Aug 15;9(8):e104078. doi: 10.1371/journal.pone.0104078. eCollection 2014.


Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1.

Hirota Y, Nakagawa K, Sawada N, Okuda N, Suhara Y, Uchino Y, Kimoto T, Funahashi N, Kamao M, Tsugawa N, Okano T.

PLoS One. 2015 Apr 15;10(4):e0125737. doi: 10.1371/journal.pone.0125737. eCollection 2015.


Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.

Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano T.

Nature. 2010 Nov 4;468(7320):117-21. doi: 10.1038/nature09464. Epub 2010 Oct 17.


Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.

Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T.

J Biol Chem. 2013 Nov 15;288(46):33071-80. doi: 10.1074/jbc.M113.477356. Epub 2013 Sep 30.


Role of UBIAD1 in Intracellular Cholesterol Metabolism and Vascular Cell Calcification.

Liu S, Guo W, Han X, Dai W, Diao Z, Liu W.

PLoS One. 2016 Feb 18;11(2):e0149639. doi: 10.1371/journal.pone.0149639. eCollection 2016.


YY1 positively regulates human UBIAD1 expression.

Funahashi N, Hirota Y, Nakagawa K, Sawada N, Watanabe M, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2015 May 1;460(2):238-44. doi: 10.1016/j.bbrc.2015.03.018. Epub 2015 Mar 12.


Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM.

Cell. 2013 Jan 31;152(3):504-18. doi: 10.1016/j.cell.2013.01.013.


Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis.

Shearer MJ, Newman P.

J Lipid Res. 2014 Mar;55(3):345-62. doi: 10.1194/jlr.R045559. Epub 2014 Jan 31. Review.


The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.

Nickerson ML, Bosley AD, Weiss JS, Kostiha BN, Hirota Y, Brandt W, Esposito D, Kinoshita S, Wessjohann L, Morham SG, Andresson T, Kruth HS, Okano T, Dean M.

Hum Mutat. 2013 Feb;34(2):317-29. doi: 10.1002/humu.22230. Epub 2012 Nov 27. Erratum in: Hum Mutat. 2013 Jul;34(7):1046.


The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.

Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA.

Elife. 2015 Mar 5;4. doi: 10.7554/eLife.05560.


[Biological significance and metabolic activation of vitamin K].

Nakagawa K.

Yakugaku Zasshi. 2013;133(12):1337-41. Review. Japanese.


Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism.

Fredericks WJ, Yin H, Lal P, Puthiyaveettil R, Malkowicz SB, Fredericks NJ, Tomaszewski J, Rauscher FJ 3rd, Malkowicz SB.

Int J Oncol. 2013 Aug;43(2):638-52. doi: 10.3892/ijo.2013.1985. Epub 2013 Jun 12.


A novel Golgi retention signal RPWS for tumor suppressor UBIAD1.

Wang X, Wang D, Jing P, Wu Y, Xia Y, Chen M, Hong L.

PLoS One. 2013 Aug 19;8(8):e72015. doi: 10.1371/journal.pone.0072015. eCollection 2013.


MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.

Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D.

Circ Res. 2012 Nov 9;111(11):1421-33. doi: 10.1161/CIRCRESAHA.112.279711. Epub 2012 Sep 5.


Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis.

Delvaeye M, De Vriese A, Zwerts F, Betz I, Moons M, Autiero M, Conway EM.

BMC Dev Biol. 2009 Mar 26;9:25. doi: 10.1186/1471-213X-9-25.


Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY.

Nat Genet. 2007 Nov;39(11):1397-402. Epub 2007 Oct 14.


Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.

Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P.

Science. 2012 Jun 8;336(6086):1306-10. doi: 10.1126/science.1218632. Epub 2012 May 10.


HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.

Stoll SJ, Bartsch S, Kroll J.

PLoS One. 2013;8(3):e58311. doi: 10.1371/journal.pone.0058311. Epub 2013 Mar 6.


VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation.

Li S, Dang YY, Oi Lam Che G, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):408-20. doi: 10.1016/j.taap.2014.09.005. Epub 2014 Sep 16.


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