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Items: 1 to 20 of 218


Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes.

Drapeau N, Lizotte F, Denhez B, Guay A, Kennedy CR, Geraldes P.

Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1188-98. doi: 10.1152/ajpendo.00560.2012. Epub 2013 Mar 26.


Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.

Denhez B, Lizotte F, Guimond MO, Jones N, Takano T, Geraldes P.

J Biol Chem. 2015 Jan 2;290(1):350-8. doi: 10.1074/jbc.M114.612721. Epub 2014 Nov 17.


Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes.

Lizotte F, Denhez B, Guay A, Gévry N, Côté AM, Geraldes P.

Diabetes. 2016 Dec;65(12):3705-3717. Epub 2016 Sep 1.


Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy.

Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL.

FASEB J. 2012 Jul;26(7):2963-74. doi: 10.1096/fj.11-202994. Epub 2012 Apr 12.


High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach.

Katsoulieris EN, Drossopoulou GI, Kotsopoulou ES, Vlahakos DV, Lianos EA, Tsilibary EC.

PLoS One. 2016 Jul 19;11(7):e0158873. doi: 10.1371/journal.pone.0158873. eCollection 2016.


Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL.

Nat Med. 2009 Nov;15(11):1298-306. doi: 10.1038/nm.2052. Epub 2009 Nov 1.


NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression.

Li R, Zhang L, Shi W, Zhang B, Liang X, Liu S, Wang W.

Exp Cell Res. 2013 Apr 15;319(7):992-1000. doi: 10.1016/j.yexcr.2013.01.007. Epub 2013 Jan 20.


Overexpression of Mafb in podocytes protects against diabetic nephropathy.

Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S.

J Am Soc Nephrol. 2014 Nov;25(11):2546-57. doi: 10.1681/ASN.2013090993. Epub 2014 Apr 10.


The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice.

Noh JR, Hwang JH, Kim YH, Kim KS, Gang GT, Kim SW, Kim DK, Shong M, Lee IK, Choi HS, Lee CH.

Int J Biochem Cell Biol. 2013 Aug;45(8):1538-45. doi: 10.1016/j.biocel.2013.05.004. Epub 2013 May 13.


BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury.

Mitu GM, Wang S, Hirschberg R.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1641-8. Epub 2007 Sep 5.


Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes.

Faour WH, Thibodeau JF, Kennedy CR.

Cell Signal. 2010 Aug;22(8):1222-30. doi: 10.1016/j.cellsig.2010.03.014. Epub 2010 Mar 31.


NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy.

Du P, Fan B, Han H, Zhen J, Shang J, Wang X, Li X, Shi W, Tang W, Bao C, Wang Z, Zhang Y, Zhang B, Wei X, Yi F.

Kidney Int. 2013 Aug;84(2):265-76. doi: 10.1038/ki.2013.113. Epub 2013 Apr 17.


Impact of high glucose and transforming growth factor-β on bioenergetic profiles in podocytes.

Stieger N, Worthmann K, Teng B, Engeli S, Das AM, Haller H, Schiffer M.

Metabolism. 2012 Aug;61(8):1073-86. doi: 10.1016/j.metabol.2011.12.003. Epub 2012 Feb 24.


SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis.

Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM.

J Cell Physiol. 2004 May;199(2):227-36.


Dysregulation of low-density lipoprotein receptor contributes to podocyte injuries in diabetic nephropathy.

Zhang Y, Ma KL, Liu J, Wu Y, Hu ZB, Liu L, Liu BC.

Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1140-8. doi: 10.1152/ajpendo.00591.2014. Epub 2015 Apr 28.


High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes.

Bai Y, Wang L, Li Y, Liu S, Li J, Wang H, Huang H.

Cell Physiol Biochem. 2006;17(1-2):57-68. Epub 2006 Feb 7.


Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway.

Li G, Li Y, Liu S, Shi Y, Chi Y, Liu G, Shan T.

J Cell Biochem. 2013 Sep;114(9):2101-13. doi: 10.1002/jcb.24559.


Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes.

Chen JX, Tuo Q, Liao DF, Zeng H.

Exp Diabetes Res. 2012;2012:836759. doi: 10.1155/2012/836759. Epub 2012 Feb 12.

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