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Items: 1 to 20 of 61

1.

Hypoxia induces a phase transition within a kinase signaling network in cancer cells.

Wei W, Shi Q, Remacle F, Qin L, Shackelford DB, Shin YS, Mischel PS, Levine RD, Heath JR.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1352-60. doi: 10.1073/pnas.1303060110. Epub 2013 Mar 25.

2.

Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature.

Kristoffersen K, Nedergaard MK, Villingshøj M, Borup R, Broholm H, Kjær A, Poulsen HS, Stockhausen MT.

Cancer Biol Ther. 2014 Jul;15(7):862-77. doi: 10.4161/cbt.28876. Epub 2014 Apr 22.

3.

Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.

Pistollato F, Rampazzo E, Abbadi S, Della Puppa A, Scienza R, D'Avella D, Denaro L, Te Kronnie G, Panchision DM, Basso G.

PLoS One. 2009 Jul 9;4(7):e6206. doi: 10.1371/journal.pone.0006206.

4.

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.

5.

Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.

Jhanwar-Uniyal M, Gillick JL, Neil J, Tobias M, Thwing ZE, Murali R.

Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.

PMID:
25442674
6.

[Prediction of the molecular response to pertubations from single cell measurements].

Remacle F, Levine RD.

Med Sci (Paris). 2014 Dec;30(12):1129-35. doi: 10.1051/medsci/20143012016. Epub 2014 Dec 24. Review. French.

8.

NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth.

Zha X, Hu Z, Ji S, Jin F, Jiang K, Li C, Zhao P, Tu Z, Chen X, Di L, Zhou H, Zhang H.

Cancer Lett. 2015 Apr 1;359(1):97-106. doi: 10.1016/j.canlet.2015.01.001. Epub 2015 Jan 8.

PMID:
25578782
9.

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.

Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.

10.

Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.

Cloninger C, Bernath A, Bashir T, Holmes B, Artinian N, Ruegg T, Anderson L, Masri J, Lichtenstein A, Gera J.

Mol Cancer Ther. 2011 Dec;10(12):2244-56. doi: 10.1158/1535-7163.MCT-11-0478. Epub 2011 Sep 12.

11.

Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures.

Kristoffersen K, Villingshøj M, Poulsen HS, Stockhausen MT.

Cancer Biol Ther. 2013 Jul;14(7):625-37. doi: 10.4161/cbt.24595. Epub 2013 May 10.

12.

The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.

Wang E, Zhang C, Polavaram N, Liu F, Wu G, Schroeder MA, Lau JS, Mukhopadhyay D, Jiang SW, O'Neill BP, Datta K, Li J.

PLoS One. 2014 Jan 23;9(1):e86102. doi: 10.1371/journal.pone.0086102. eCollection 2014.

13.

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.

Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15.

14.

Role of mTOR in glioblastoma.

Duzgun Z, Eroglu Z, Biray Avci C.

Gene. 2016 Jan 10;575(2 Pt 1):187-90. doi: 10.1016/j.gene.2015.08.060. Epub 2015 Sep 1. Review.

PMID:
26341051
15.

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.

Mortensen DS, Fultz KE, Xu S, Xu W, Packard G, Khambatta G, Gamez JC, Leisten J, Zhao J, Apuy J, Ghoreishi K, Hickman M, Narla RK, Bissonette R, Richardson S, Peng SX, Perrin-Ninkovic S, Tran T, Shi T, Yang WQ, Tong Z, Cathers BE, Moghaddam MF, Canan SS, Worland P, Sankar S, Raymon HK.

Mol Cancer Ther. 2015 Jun;14(6):1295-305. doi: 10.1158/1535-7163.MCT-14-1052. Epub 2015 Apr 8.

16.

PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.

J Biol Chem. 2014 Oct 24;289(43):29739-49. doi: 10.1074/jbc.M114.584821. Epub 2014 Aug 27.

17.

HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells.

Marhold M, Tomasich E, El-Gazzar A, Heller G, Spittler A, Horvat R, Krainer M, Horak P.

Mol Cancer Res. 2015 Mar;13(3):556-64. doi: 10.1158/1541-7786.MCR-14-0153-T. Epub 2014 Oct 27.

18.

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.

Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS.

Clin Cancer Res. 2013 Oct 15;19(20):5722-32. doi: 10.1158/1078-0432.CCR-13-0527. Epub 2013 Sep 12.

19.

Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy.

Oliver L, Olivier C, Marhuenda FB, Campone M, Vallette FM.

Curr Mol Pharmacol. 2009 Nov;2(3):263-84. Review.

PMID:
20021464
20.

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