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Items: 1 to 20 of 217

1.

Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

Russo SB, Tidhar R, Futerman AH, Cowart LA.

J Biol Chem. 2013 May 10;288(19):13397-409. doi: 10.1074/jbc.M112.428185. Epub 2013 Mar 25.

2.

The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.

Hornemann T, Penno A, Rütti MF, Ernst D, Kivrak-Pfiffner F, Rohrer L, von Eckardstein A.

J Biol Chem. 2009 Sep 25;284(39):26322-30. doi: 10.1074/jbc.M109.023192. Epub 2009 Aug 1.

3.

Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.

Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, Zuo J.

Cell Res. 2007 Dec;17(12):1030-40. Erratum in: Cell Res. 2008 Feb;18(2):324.

4.

Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle.

Obanda DN, Yu Y, Wang ZQ, Cefalu WT.

J Nutr Biochem. 2015 Jul;26(7):687-95. doi: 10.1016/j.jnutbio.2015.01.007. Epub 2015 Mar 5.

5.

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes.

Russo SB, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA.

J Clin Invest. 2012 Nov;122(11):3919-30.

6.

Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.

Mandon EC, van Echten G, Birk R, Schmidt RR, Sandhoff K.

Eur J Biochem. 1991 Jun 15;198(3):667-74.

7.

Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice.

Hojjati MR, Li Z, Jiang XC.

Biochim Biophys Acta. 2005 Oct 15;1737(1):44-51. Epub 2005 Aug 24.

PMID:
16216550
8.

Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.

Murakami I, Wakasa Y, Yamashita S, Kurihara T, Zama K, Kobayashi N, Mizutani Y, Mitsutake S, Shigyo T, Igarashi Y.

Lipids Health Dis. 2011 Aug 24;10:150. doi: 10.1186/1476-511X-10-150.

9.

Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.

Gupta SD, Gable K, Alexaki A, Chandris P, Proia RL, Dunn TM, Harmon JM.

J Biol Chem. 2015 Jan 2;290(1):90-8. doi: 10.1074/jbc.M114.588236. Epub 2014 Nov 13.

11.

ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity.

Kimberlin AN, Han G, Luttgeharm KD, Chen M, Cahoon RE, Stone JM, Markham JE, Dunn TM, Cahoon EB.

Plant Physiol. 2016 Oct;172(2):889-900. Epub 2016 Aug 9.

12.

Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.

Cowart LA, Hannun YA.

J Biol Chem. 2007 Apr 20;282(16):12330-40. Epub 2007 Feb 23.

13.

Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells.

Kiefer K, Carreras-Sureda A, García-López R, Rubio-Moscardó F, Casas J, Fabriàs G, Vicente R.

J Biol Chem. 2015 Jan 30;290(5):2822-30. doi: 10.1074/jbc.M114.595116. Epub 2014 Dec 17.

14.

An overview of sphingolipid metabolism: from synthesis to breakdown.

Gault CR, Obeid LM, Hannun YA.

Adv Exp Med Biol. 2010;688:1-23. Review.

15.

Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption.

Linn SC, Kim HS, Keane EM, Andras LM, Wang E, Merrill AH Jr.

Biochem Soc Trans. 2001 Nov;29(Pt 6):831-5. Review.

PMID:
11709083
16.

Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.

Lee SY, Kim JR, Hu Y, Khan R, Kim SJ, Bharadwaj KG, Davidson MM, Choi CS, Shin KO, Lee YM, Park WJ, Park IS, Jiang XC, Goldberg IJ, Park TS.

J Biol Chem. 2012 May 25;287(22):18429-39. doi: 10.1074/jbc.M111.296947. Epub 2012 Apr 9.

17.

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.

Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski J, Hicks WL, Krebs MP, Naggert J, Hannun YA, Dunn TM, Nishina PM.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12962-7. doi: 10.1073/pnas.1516733112. Epub 2015 Oct 5.

18.

Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.

Melland-Smith M, Ermini L, Chauvin S, Craig-Barnes H, Tagliaferro A, Todros T, Post M, Caniggia I.

Autophagy. 2015 Apr 3;11(4):653-69. doi: 10.1080/15548627.2015.1034414.

20.

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver.

He Q, Suzuki H, Sharma N, Sharma RP.

Toxicol Sci. 2006 Dec;94(2):388-97. Epub 2006 Sep 7.

PMID:
16960033

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