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Items: 1 to 20 of 126

1.

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.

Mizuno A, Miura S, Watanabe M, Ito Y, Yamada S, Odagami T, Kogami Y, Arisawa M, Shuto S.

Org Lett. 2013 Apr 5;15(7):1686-9. doi: 10.1021/ol400469w. Epub 2013 Mar 25.

PMID:
23528142
2.

Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.

Milanole G, Couve-Bonnaire S, Bonfanti JF, Jubault P, Pannecoucke X.

J Org Chem. 2013 Jan 18;78(2):212-23. doi: 10.1021/jo302222n. Epub 2012 Dec 17.

PMID:
23227990
3.

Three-step synthesis of cyclopropyl peptidomimetics.

Dunlap N, Lankford KR, Pathiranage AL, Taylor J, Reddy N, Gouger D, Singer P, Griffin K, Reibenspies J.

Org Lett. 2011 Sep 16;13(18):4879-81. doi: 10.1021/ol201828u. Epub 2011 Aug 24.

PMID:
21863816
4.

Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.

Singh A, Wilczynski A, Holder JR, Witek RM, Dirain ML, Xiang Z, Edison AS, Haskell-Luevano C.

J Med Chem. 2011 Mar 10;54(5):1379-90. doi: 10.1021/jm101425m. Epub 2011 Feb 9.

5.

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.

Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.

J Med Chem. 2004 Apr 22;47(9):2194-207.

PMID:
15084118
6.

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands.

Sernissi L, Trabocchi A, Scarpi D, Bianchini F, Occhiato EG.

Bioorg Med Chem. 2016 Feb 15;24(4):703-11. doi: 10.1016/j.bmc.2015.12.039. Epub 2015 Dec 24.

PMID:
26753814
7.

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone.

Watanabe M, Kobayashi T, Hirokawa T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S.

Org Biomol Chem. 2012 Jan 28;10(4):736-45. doi: 10.1039/c1ob06496g. Epub 2011 Nov 28.

PMID:
22120611
8.

Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors.

Martin SF, Dorsey GO, Gane T, Hillier MC, Kessler H, Baur M, Mathä B, Erickson JW, Bhat TN, Munshi S, Gulnik SV, Topol IA.

J Med Chem. 1998 May 7;41(10):1581-97.

PMID:
9572884
9.

Parallel sheet structure in cyclopropane gamma-peptides stabilized by C-H...O hydrogen bonds.

Qureshi MK, Smith MD.

Chem Commun (Camb). 2006 Dec 28;(48):5006-8. Epub 2006 Nov 6.

PMID:
17146509
10.

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Eildal JN, Stuhr-Hansen N, Deeskamp R, Gottschalk M, Pedersen SW, Kristensen AS, Strømgaard K.

J Med Chem. 2011 Mar 10;54(5):1333-46. doi: 10.1021/jm1013924. Epub 2011 Feb 15.

PMID:
21322614
11.
12.

Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.

Watanabe M, Hirokawa T, Kobayashi T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S.

J Med Chem. 2010 May 13;53(9):3585-93. doi: 10.1021/jm901848b.

PMID:
20397706
13.

Ugi 4-CR/Pictet-Spengler reaction as a short route to tryptophan-derived peptidomimetics.

Lesma G, Cecchi R, Crippa S, Giovanelli P, Meneghetti F, Musolino M, Sacchetti A, Silvani A.

Org Biomol Chem. 2012 Dec 7;10(45):9004-12. doi: 10.1039/c2ob26301g. Epub 2012 Oct 16.

PMID:
23073566
14.
15.

A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics.

Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD.

Chemistry. 2015 Oct 12;21(42):14699-702. doi: 10.1002/chem.201501366. Epub 2015 Aug 17.

PMID:
26384862
16.

Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand.

Sernissi L, Petrović M, Scarpi D, Guarna A, Trabocchi A, Bianchini F, Occhiato EG.

Chemistry. 2014 Aug 25;20(35):11187-203. doi: 10.1002/chem.201403077. Epub 2014 Jul 28.

PMID:
25069617
17.

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Kobayashi T, Watanabe M, Yoshida A, Yamada S, Ito M, Abe H, Ito Y, Arisawa M, Shuto S.

Bioorg Med Chem. 2010 Feb;18(3):1076-82. doi: 10.1016/j.bmc.2009.12.046. Epub 2009 Dec 23.

PMID:
20045649
18.

Photocontrolled chignolin-derived β-hairpin peptidomimetics.

Podewin T, Rampp MS, Turkanovic I, Karaghiosoff KL, Zinth W, Hoffmann-Röder A.

Chem Commun (Camb). 2015 Mar 7;51(19):4001-4. doi: 10.1039/c4cc10304a.

PMID:
25622946
19.

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin.

Palomo C, Aizpurua JM, Benito A, Miranda JI, Fratila RM, Matute C, Domercq M, Gago F, Martin-Santamaria S, Linden A.

J Am Chem Soc. 2003 Dec 31;125(52):16243-60.

PMID:
14692766
20.

Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.

Stefanucci A, Pinnen F, Feliciani F, Cacciatore I, Lucente G, Mollica A.

Int J Mol Sci. 2011;12(5):2853-90. doi: 10.3390/ijms12052853. Epub 2011 May 3. Review.

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