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Items: 1 to 20 of 63

1.

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe.

Lee K, Ren T, Côté M, Gholamreza B, Misasi J, Bruchez A, Cunningham J.

ACS Med Chem Lett. 2013 Feb 14;4(2):239-243. Epub 2012 Dec 19.

2.

Novel Small Molecule Entry Inhibitors of Ebola Virus.

Basu A, Mills DM, Mitchell D, Ndungo E, Williams JD, Herbert AS, Dye JM, Moir DT, Chandran K, Patterson JL, Rong L, Bowlin TL.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S425-34. doi: 10.1093/infdis/jiv223. Epub 2015 Jul 22.

3.

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.

Côté M, Misasi J, Ren T, Bruchez A, Lee K, Filone CM, Hensley L, Li Q, Ory D, Chandran K, Cunningham J.

Nature. 2011 Aug 24;477(7364):344-8. doi: 10.1038/nature10380.

4.

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.

Shoemaker CJ, Schornberg KL, Delos SE, Scully C, Pajouhesh H, Olinger GG, Johansen LM, White JM.

PLoS One. 2013;8(2):e56265. doi: 10.1371/journal.pone.0056265. Epub 2013 Feb 18. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/76780c06-ac81-48a3-8cce-509da6858fe5.

5.

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

Ndungo E, Herbert AS, Raaben M, Obernosterer G, Biswas R, Miller EH, Wirchnianski AS, Carette JE, Brummelkamp TR, Whelan SP, Dye JM, Chandran K.

mSphere. 2016 Mar 30;1(2). pii: e00007-16. doi: 10.1128/mSphere.00007-16. eCollection 2016 Mar-Apr.

6.

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

Herbert AS, Davidson C, Kuehne AI, Bakken R, Braigen SZ, Gunn KE, Whelan SP, Brummelkamp TR, Twenhafel NA, Chandran K, Walkley SU, Dye JM.

MBio. 2015 May 26;6(3):e00565-15. doi: 10.1128/mBio.00565-15.

7.

Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step.

Mingo RM, Simmons JA, Shoemaker CJ, Nelson EA, Schornberg KL, D'Souza RS, Casanova JE, White JM.

J Virol. 2015 Mar;89(5):2931-43. doi: 10.1128/JVI.03398-14. Epub 2014 Dec 31.

8.

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR.

Nature. 2011 Aug 24;477(7364):340-3. doi: 10.1038/nature10348.

9.

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway.

Spence JS, Krause TB, Mittler E, Jangra RK, Chandran K.

MBio. 2016 Feb 9;7(1):e01857-15. doi: 10.1128/mBio.01857-15.

10.

Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein.

Li Q, Ma L, Yi D, Wang H, Wang J, Zhang Y, Guo Y, Li X, Zhou J, Shi Y, Gao GF, Cen S.

Antiviral Res. 2018 Apr 27;155:1-11. doi: 10.1016/j.antiviral.2018.04.020. [Epub ahead of print]

PMID:
29709562
11.

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1.

Ng M, Ndungo E, Jangra RK, Cai Y, Postnikova E, Radoshitzky SR, Dye JM, Ramírez de Arellano E, Negredo A, Palacios G, Kuhn JH, Chandran K.

Virology. 2014 Nov;468-470:637-646. doi: 10.1016/j.virol.2014.08.019. Epub 2014 Oct 11.

12.

Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus.

Kuroda M, Fujikura D, Nanbo A, Marzi A, Noyori O, Kajihara M, Maruyama J, Matsuno K, Miyamoto H, Yoshida R, Feldmann H, Takada A.

J Virol. 2015 Jun;89(12):6481-93. doi: 10.1128/JVI.03156-14. Epub 2015 Apr 8.

13.

In silico assessment of phosphorylation and O-β-GlcNAcylation sites in human NPC1 protein critical for Ebola virus entry.

Basharat Z, Yasmin A.

Infect Genet Evol. 2015 Aug;34:326-38. doi: 10.1016/j.meegid.2015.06.001. Epub 2015 Jun 3.

PMID:
26048414
14.

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein.

Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR.

Chembiochem. 2012 Nov 26;13(17):2549-57. doi: 10.1002/cbic.201200493. Epub 2012 Oct 30.

15.

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species- and cell-type-specific manner.

Martinez O, Ndungo E, Tantral L, Miller EH, Leung LW, Chandran K, Basler CF.

J Virol. 2013 Mar;87(6):3324-34. doi: 10.1128/JVI.01598-12. Epub 2013 Jan 9.

16.

Identification of a small-molecule entry inhibitor for filoviruses.

Basu A, Li B, Mills DM, Panchal RG, Cardinale SC, Butler MM, Peet NP, Majgier-Baranowska H, Williams JD, Patel I, Moir DT, Bavari S, Ray R, Farzan MR, Rong L, Bowlin TL.

J Virol. 2011 Apr;85(7):3106-19. doi: 10.1128/JVI.01456-10. Epub 2011 Jan 26.

17.

Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K.

EMBO J. 2012 Apr 18;31(8):1947-60. doi: 10.1038/emboj.2012.53. Epub 2012 Mar 6.

18.

Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor.

Krishnan A, Miller EH, Herbert AS, Ng M, Ndungo E, Whelan SP, Dye JM, Chandran K.

Viruses. 2012 Oct 25;4(11):2471-84. doi: 10.3390/v4112471.

19.

Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species.

Kurosaki Y, Ueda MT, Nakano Y, Yasuda J, Koyanagi Y, Sato K, Nakagawa S.

J Gen Virol. 2018 Jan 4. doi: 10.1099/jgv.0.000999. [Epub ahead of print]

20.

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication.

Luthra P, Liang J, Pietzsch CA, Khadka S, Edwards MR, Wei S, De S, Posner B, Bukreyev A, Ready JM, Basler CF.

Antiviral Res. 2018 Feb;150:193-201. doi: 10.1016/j.antiviral.2017.12.019. Epub 2017 Dec 30.

PMID:
29294299

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