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Items: 1 to 20 of 168

1.

Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase.

Cho JH, Lee MY, Baig IA, Ha NR, Kim J, Yoon MY.

Biochimie. 2013 Jul;95(7):1411-21. doi: 10.1016/j.biochi.2013.03.007. Epub 2013 Mar 22.

PMID:
23523771
3.

Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors.

Choi KJ, Noh KM, Kim DE, Ha BH, Kim EE, Yoon MY.

Arch Biochem Biophys. 2007 Oct 1;466(1):24-30. Epub 2007 Jul 28.

PMID:
17718999
4.

Cloning, characterization and evaluation of potent inhibitors of Shigella sonnei acetohydroxyacid synthase catalytic subunit.

Lim WM, Baig IJ, La IJ, Choi JD, Kim DE, Kim SK, Hyun JW, Kim G, Kang CH, Kim YJ, Yoon MY.

Biochim Biophys Acta. 2011 Dec;1814(12):1825-31. doi: 10.1016/j.bbapap.2011.09.007. Epub 2011 Oct 11.

PMID:
22015678
5.

Evaluation of substituted triazol-1-yl-pyrimidines as inhibitors of Bacillus anthracis acetohydroxyacid synthase.

Gedi V, Jayaraman K, Kalme S, Park HY, Park HC, La IJ, Hahn HG, Yoon MY.

Biochim Biophys Acta. 2010 Jun;1804(6):1369-75. doi: 10.1016/j.bbapap.2010.02.002. Epub 2010 Feb 17.

PMID:
20170757
6.

Acetohydroxyacid synthase: a target for antimicrobial drug discovery.

Pue N, Guddat LW.

Curr Pharm Des. 2014;20(5):740-53.

PMID:
23688082
7.

Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase.

Gedi V, Moon JY, Lim WM, Lee MY, Lee SC, Koo BS, Govindwar S, Yoon MY.

Enzyme Microb Technol. 2011 Jun 10;49(1):1-5. doi: 10.1016/j.enzmictec.2011.04.004. Epub 2011 Apr 8.

PMID:
22112263
8.

Bacterial acetohydroxyacid synthase and its inhibitors--a summary of their structure, biological activity and current status.

Gedi V, Yoon MY.

FEBS J. 2012 Mar;279(6):946-63. doi: 10.1111/j.1742-4658.2012.08505.x. Epub 2012 Feb 27. Review.

9.

Characterization of acetohydroxyacid synthase I from Escherichia coli K-12 and identification of its inhibitors.

Pham NC, Moon JY, Cho JH, Lee SJ, Park JS, Kim DE, Park Y, Yoon MY.

Biosci Biotechnol Biochem. 2010;74(11):2281-6. Epub 2010 Nov 7.

10.

Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase.

Baig IA, Moon JY, Lee SC, Ryoo SW, Yoon MY.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1338-50. doi: 10.1016/j.bbapap.2015.05.003. Epub 2015 May 16.

PMID:
25988243
11.

Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.

Baig IA, Gedi V, Lee SC, Koh SH, Yoon MY.

Enzyme Microb Technol. 2013 Sep 10;53(4):243-9. doi: 10.1016/j.enzmictec.2013.05.006. Epub 2013 May 30.

PMID:
23931689
12.

Development of potent chemical antituberculosis agents targeting Mycobacterium tuberculosis acetohydroxyacid synthase.

Jung IP, Ha NR, Lee SC, Ryoo SW, Yoon MY.

Int J Antimicrob Agents. 2016 Sep;48(3):247-58. doi: 10.1016/j.ijantimicag.2016.04.031. Epub 2016 Jul 6.

PMID:
27451857
13.

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

Lee YT, Cui CJ, Chow EW, Pue N, Lonhienne T, Wang JG, Fraser JA, Guddat LW.

J Med Chem. 2013 Jan 10;56(1):210-9. doi: 10.1021/jm301501k. Epub 2012 Dec 31.

PMID:
23237384
15.

Discovery of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis by virtual screening and bioassay.

Wang D, Zhu X, Cui C, Dong M, Jiang H, Li Z, Liu Z, Zhu W, Wang JG.

J Chem Inf Model. 2013 Feb 25;53(2):343-53. doi: 10.1021/ci3004545. Epub 2013 Jan 30.

PMID:
23316686
17.

Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.

Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, Zhang LH, Verma C, Tan P.

Antimicrob Agents Chemother. 2013 Mar;57(3):1513-7. doi: 10.1128/AAC.02327-12. Epub 2012 Dec 21.

18.

Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16.

Lu J, Brigham CJ, Plassmeier JK, Sinskey AJ.

Appl Microbiol Biotechnol. 2015 Jan;99(2):761-74. doi: 10.1007/s00253-014-5965-3. Epub 2014 Aug 1.

PMID:
25081555
19.
20.

Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.

Belenky I, Steinmetz A, Vyazmensky M, Barak Z, Tittmann K, Chipman DM.

FEBS J. 2012 Jun;279(11):1967-79. doi: 10.1111/j.1742-4658.2012.08577.x. Epub 2012 Apr 20.

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