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Items: 1 to 20 of 96

1.

Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.

Kesisova IA, Nakos KC, Tsolou A, Angelis D, Lewis J, Chatzaki A, Agianian B, Giannis A, Koffa MD.

PLoS One. 2013;8(3):e58485. doi: 10.1371/journal.pone.0058485. Epub 2013 Mar 13.

2.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.

Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang CY, Chao YS, Wu SY, Hsieh HP, Chi YH.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1779-87. doi: 10.1073/pnas.1220523110. Epub 2013 Apr 22.

3.

Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.

Matsuhashi A, Ohno T, Kimura M, Hara A, Saio M, Nagano A, Kawai G, Saitou M, Takigami I, Yamada K, Okano Y, Shimizu K.

Curr Cancer Drug Targets. 2012 Jul;12(6):625-39.

PMID:
22463590
4.

MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

Huck JJ, Zhang M, McDonald A, Bowman D, Hoar KM, Stringer B, Ecsedy J, Manfredi MG, Hyer ML.

Mol Cancer Res. 2010 Mar;8(3):373-84. doi: 10.1158/1541-7786.MCR-09-0300. Epub 2010 Mar 2.

5.

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM.

Curr Biol. 2007 Feb 20;17(4):304-15. Epub 2007 Feb 8.

6.

Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.

Wang W, Stukenberg PT, Brautigan DL.

Mol Biol Cell. 2008 Nov;19(11):4852-62. doi: 10.1091/mbc.E08-05-0460. Epub 2008 Aug 20.

7.

Advances in Aurora kinase inhibitor patents.

Coumar MS, Cheung CH, Chang JY, Hsieh HP.

Expert Opin Ther Pat. 2009 Mar;19(3):321-56. doi: 10.1517/13543770802646949. Review.

PMID:
19441907
8.

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.

Manfredi MG, Ecsedy JA, Meetze KA, Balani SK, Burenkova O, Chen W, Galvin KM, Hoar KM, Huck JJ, LeRoy PJ, Ray ET, Sells TB, Stringer B, Stroud SG, Vos TJ, Weatherhead GS, Wysong DR, Zhang M, Bolen JB, Claiborne CF.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. Epub 2007 Feb 23.

9.

Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.

Sloane DA, Trikic MZ, Chu ML, Lamers MB, Mason CS, Mueller I, Savory WJ, Williams DH, Eyers PA.

ACS Chem Biol. 2010 Jun 18;5(6):563-76. doi: 10.1021/cb100053q.

PMID:
20426425
11.

Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, Gianellini L, Cappella P, Isacchi A, Moll J, Rusconi L.

J Biol Chem. 2010 Apr 16;285(16):11775-85. doi: 10.1074/jbc.M109.068312. Epub 2010 Feb 22.

12.

Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics.

Lorenzo C, Liao Q, Hardwicke MA, Ducommun B.

Cell Cycle. 2009 Jun 1;8(11):1733-7. Epub 2009 Jun 2.

PMID:
19395863
13.

Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.

Stenoien DL, Sen S, Mancini MA, Brinkley BR.

Cell Motil Cytoskeleton. 2003 Jun;55(2):134-46.

PMID:
12740874
14.

Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3.

Jang CY, Coppinger JA, Yates JR 3rd, Fang G.

Biochem Biophys Res Commun. 2011 Apr 29;408(1):174-9. doi: 10.1016/j.bbrc.2011.04.004. Epub 2011 Apr 5.

PMID:
21473853
15.

Development and biological evaluation of a novel aurora A kinase inhibitor.

Sardon T, Cottin T, Xu J, Giannis A, Vernos I.

Chembiochem. 2009 Feb 13;10(3):464-78. doi: 10.1002/cbic.200800600.

PMID:
19199284
16.

Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain.

Wong J, Lerrigo R, Jang CY, Fang G.

Mol Biol Cell. 2008 May;19(5):2083-91. doi: 10.1091/mbc.E07-10-1088. Epub 2008 Mar 5.

17.

Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.

LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.

Cancer Res. 2007 Jun 1;67(11):5362-70.

18.

Aurora kinase inhibitors in preclinical and clinical testing.

Cheung CH, Coumar MS, Hsieh HP, Chang JY.

Expert Opin Investig Drugs. 2009 Apr;18(4):379-98. doi: 10.1517/13543780902806392 . Review.

PMID:
19335272
19.

Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases.

Hoang TM, Favier B, Valette A, Barette C, Nguyen CH, Lafanechère L, Grierson DS, Dimitrov S, Molla A.

Cell Cycle. 2009 Mar 1;8(5):765-72. Epub 2009 Mar 18.

20.

The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

Ma N, Matsunaga S, Morimoto A, Sakashita G, Urano T, Uchiyama S, Fukui K.

J Cell Sci. 2011 Feb 1;124(Pt 3):394-404. doi: 10.1242/jcs.063347.

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