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Items: 1 to 20 of 150

1.

Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.

Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV Jr, Roberson ED.

J Neurosci. 2013 Mar 20;33(12):5352-61. doi: 10.1523/JNEUROSCI.6103-11.2013.

2.

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia.

Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, Beal MF, Nathan C, Thomas B, Ding A.

FASEB J. 2010 Dec;24(12):4639-47. doi: 10.1096/fj.10-161471.

3.

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ.

Neurobiol Dis. 2012 Jan;45(1):395-408. doi: 10.1016/j.nbd.2011.08.029.

4.

Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.

Arrant AE, Filiano AJ, Warmus BA, Hall AM, Roberson ED.

Genes Brain Behav. 2016 Jul;15(6):588-603. doi: 10.1111/gbb.12300.

PMID:
27213486
5.

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.

Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV Jr.

J Clin Invest. 2012 Nov;122(11):3955-9. doi: 10.1172/JCI63113.

6.

Synaptic dysfunction in progranulin-deficient mice.

Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, Gregg J, Lu G, Feldman HH, Mackenzie IR, Raymond LA, Leavitt BR.

Neurobiol Dis. 2012 Feb;45(2):711-22. doi: 10.1016/j.nbd.2011.10.016.

PMID:
22062772
7.

Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds.

Petkau TL, Hill A, Leavitt BR.

Neuroscience. 2016 Feb 19;315:175-95. doi: 10.1016/j.neuroscience.2015.12.006.

PMID:
26701296
8.

Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.

Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Li J, Donnelly-Roberts D, Gan L.

Biochem Pharmacol. 2015 Oct 15;97(4):454-62. doi: 10.1016/j.bcp.2015.07.016.

9.

Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.

Yang Y, Aloi MS, Cudaback E, Josephsen SR, Rice SJ, Jorstad NL, Keene CD, Montine TJ.

Lab Invest. 2014 Nov;94(11):1224-36. doi: 10.1038/labinvest.2014.113.

10.

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.

Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, Ivanoiu A, Vandenbulcke M, Vandenberghe R, Cras P, De Deyn PP, Martin JJ, Maudsley S, Haass C, Cruts M, Van Broeckhoven C; Belgian Neurology (BELNEU) consortium..

Acta Neuropathol Commun. 2015 Nov 10;3:68. doi: 10.1186/s40478-015-0246-7.

11.

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.

Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.

Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6.

PMID:
24619111
12.

Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation.

Alberici A, Archetti S, Pilotto A, Premi E, Cosseddu M, Bianchetti A, Semeraro F, Salvetti M, Muiesan ML, Padovani A, Borroni B.

Neurol Sci. 2014 Aug;35(8):1215-9. doi: 10.1007/s10072-014-1683-y.

PMID:
24569924
13.

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice.

Arrant AE, Patel AR, Roberson ED.

eNeuro. 2015 May-Jun;2(3). pii: 0061.

14.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L.

J Exp Med. 2014 Sep 22;211(10):1937-45. doi: 10.1084/jem.20140214.

15.

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.

Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV Jr, Kukar T, Tansey MG.

J Neurosci. 2013 May 22;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013.

16.

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.

Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S.

J Pathol. 2012 Sep;228(1):67-76. doi: 10.1002/path.4043.

PMID:
22733568
17.

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Oct 10;250:8-19. doi: 10.1016/j.neuroscience.2013.06.049.

PMID:
23830905
18.

Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia.

van Swieten JC, Heutink P.

Lancet Neurol. 2008 Oct;7(10):965-74. doi: 10.1016/S1474-4422(08)70194-7. Review.

PMID:
18771956
19.

The novel GRN g.1159_1160delTG mutation is associated with behavioral variant frontotemporal dementia.

Calvi A, Cioffi SM, Caffarra P, Fenoglio C, Serpente M, Pietroboni AM, Arighi A, Ghezzi L, Gardini S, Scarpini E, Galimberti D.

J Alzheimers Dis. 2015;44(1):277-82. doi: 10.3233/JAD-141380.

PMID:
25261445
20.

Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.

Bruni AC, Momeni P, Bernardi L, Tomaino C, Frangipane F, Elder J, Kawarai T, Sato C, Pradella S, Wakutani Y, Anfossi M, Gallo M, Geracitano S, Costanzo A, Smirne N, Curcio SA, Mirabelli M, Puccio G, Colao R, Maletta RG, Kertesz A, St George-Hyslop P, Hardy J, Rogaeva E.

Neurology. 2007 Jul 10;69(2):140-7.

PMID:
17620546
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