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Items: 1 to 20 of 152

1.

Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells.

Rao S, Liu X, Freedman BD, Behrens EM.

J Biol Chem. 2013 May 3;288(18):12448-58. doi: 10.1074/jbc.M113.454405. Epub 2013 Mar 20.

2.

The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.

Lin YC, Huang DY, Chu CL, Lin YL, Lin WW.

Sci Signal. 2013 Aug 20;6(289):ra71. doi: 10.1126/scisignal.2003973.

PMID:
23962979
3.

Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages.

Sun H, Xu XY, Tian XL, Shao HT, Wu XD, Wang Q, Su X, Shi Y.

Immunobiology. 2014 Jan;219(1):25-36. doi: 10.1016/j.imbio.2013.06.013. Epub 2013 Jul 4.

PMID:
23886693
4.

Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.

Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K.

J Biol Chem. 2014 Nov 7;289(45):31565-75. doi: 10.1074/jbc.M114.581322. Epub 2014 Sep 22.

5.

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway.

Lin YC, Huang DY, Chu CL, Lin WW.

Mol Immunol. 2010 Apr;47(7-8):1569-78. doi: 10.1016/j.molimm.2010.01.008.

PMID:
20138367
6.

Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

Ostrop J, Jozefowski K, Zimmermann S, Hofmann K, Strasser E, Lepenies B, Lang R.

J Immunol. 2015 Sep 1;195(5):2417-28. doi: 10.4049/jimmunol.1500102. Epub 2015 Jul 22.

7.

Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells.

Ziegler S, Gartner K, Scheuermann U, Zoeller T, Hantzschmann J, Over B, Foermer S, Heeg K, Bekeredjian-Ding I.

Eur J Immunol. 2014 May;44(5):1285-98. doi: 10.1002/eji.201343994. Epub 2014 Feb 19.

8.

Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.

Kuriakose T, Rada B, Watford WT.

J Biol Chem. 2014 Dec 26;289(52):36089-100. doi: 10.1074/jbc.M114.587121. Epub 2014 Nov 5.

9.

Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways.

Li B, Cramer D, Wagner S, Hansen R, King C, Kakar S, Ding C, Yan J.

Clin Immunol. 2007 Aug;124(2):170-81. Epub 2007 Jun 14.

10.

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D.

J Immunol. 2010 Apr 1;184(7):3665-76. doi: 10.4049/jimmunol.0903642. Epub 2010 Mar 1.

11.

Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.

Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, Bergstrand S, Lönn D, Cevallos RR, Pereira RM, Lopes UG, Travassos LH, Paiva CN, Bozza MT.

J Biol Chem. 2010 Oct 22;285(43):32844-51. doi: 10.1074/jbc.M110.146076. Epub 2010 Aug 20.

12.

Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells.

Xu S, Huo J, Lee KG, Kurosaki T, Lam KP.

J Biol Chem. 2009 Mar 13;284(11):7038-46. doi: 10.1074/jbc.M806650200. Epub 2009 Jan 9.

13.

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.

Sanjuan MA, Rao N, Lai KT, Gu Y, Sun S, Fuchs A, Fung-Leung WP, Colonna M, Karlsson L.

J Cell Biol. 2006 Mar 27;172(7):1057-68.

14.

β-Glucan-Activated Human B Lymphocytes Participate in Innate Immune Responses by Releasing Proinflammatory Cytokines and Stimulating Neutrophil Chemotaxis.

Ali MF, Driscoll CB, Walters PR, Limper AH, Carmona EM.

J Immunol. 2015 Dec 1;195(11):5318-26. doi: 10.4049/jimmunol.1500559. Epub 2015 Oct 30.

15.

Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.

Liao C, Hsu J, Kim Y, Hu DQ, Xu D, Zhang J, Pashine A, Menke J, Whittard T, Romero N, Truitt T, Slade M, Lukacs C, Hermann J, Zhou M, Lucas M, Narula S, DeMartino J, Tan SL.

Arthritis Res Ther. 2013 Oct 4;15(5):R146. doi: 10.1186/ar4329.

16.

Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation.

Wang C, Liu X, Liu Y, Zhang Q, Yao Z, Huang B, Zhang P, Li N, Cao X.

J Biol Chem. 2013 Aug 23;288(34):24600-8. doi: 10.1074/jbc.M113.473397. Epub 2013 Jul 15.

17.

Coupling of C3bi to IgG inhibits the tyrosine phosphorylation signaling cascade downstream Syk and reduces cytokine induction in monocytes.

Trinidad AG, de la Puerta ML, Fernández N, Bayón Y, Crespo MS, Alonso A.

J Leukoc Biol. 2006 May;79(5):1073-82. Epub 2006 Feb 24.

PMID:
16501050
18.

Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.

Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A.

Genes Cells. 2008 Feb;13(2):199-208. doi: 10.1111/j.1365-2443.2007.01159.x.

19.

IL-4R(alpha), a new member that associates with Syk kinase: implication in IL-4-induced human neutrophil functions.

Ennaciri J, Girard D.

J Immunol. 2009 Oct 15;183(8):5261-9. doi: 10.4049/jimmunol.0900109. Epub 2009 Sep 25. Erratum in: J Immunol. 2010 Feb 1;184(3):1654.

20.

Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.

Yin H, Zhou H, Kang Y, Zhang X, Duan X, Alnabhan R, Liang S, Scott DA, Lamont RJ, Shang J, Wang H.

Biochim Biophys Acta. 2016 Mar;1860(3):588-98. doi: 10.1016/j.bbagen.2015.12.012. Epub 2015 Dec 17.

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