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Items: 1 to 20 of 199

1.

Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.

Larrieta-Carrasco E, León-Mimila P, Villarreal-Molina T, Villamil-Ramírez H, Romero-Hidalgo S, Jacobo-Albavera L, Gutiérrez-Vidal R, López-Contreras BE, Guillén-Pineda LE, Sánchez-Muñoz F, Bojalil R, Mejía-Domínguez AM, Méndez-Sánchez N, Domínguez-López A, Aguilar-Salinas CA, Canizales-Quinteros S.

Gene. 2013 May 15;520(2):185-8. doi: 10.1016/j.gene.2013.03.038. Epub 2013 Mar 17.

PMID:
23510779
2.

PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations.

Larrieta-Carrasco E, Acuña-Alonzo V, Velázquez-Cruz R, Barquera-Lozano R, León-Mimila P, Villamil-Ramírez H, Menjivar M, Romero-Hidalgo S, Méndez-Sánchez N, Cárdenas V, Bañuelos-Moreno M, Flores YN, Quiterio M, Salmerón J, Sánchez-Muñoz F, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S.

Mol Biol Rep. 2014 Jul;41(7):4705-11. doi: 10.1007/s11033-014-3341-0. Epub 2014 Apr 2.

PMID:
24691744
3.

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA.

Pediatr Obes. 2015 Apr;10(2):84-90. doi: 10.1111/ijpo.234. Epub 2014 Jun 11.

PMID:
24916969
4.

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.

Romeo S, Sentinelli F, Cambuli VM, Incani M, Congiu T, Matta V, Pilia S, Huang-Doran I, Cossu E, Loche S, Baroni MG.

J Hepatol. 2010 Aug;53(2):335-8. doi: 10.1016/j.jhep.2010.02.034. Epub 2010 Apr 27.

PMID:
20546964
5.

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.

Giudice EM, Grandone A, Cirillo G, Santoro N, Amato A, Brienza C, Savarese P, Marzuillo P, Perrone L.

PLoS One. 2011;6(11):e27933. doi: 10.1371/journal.pone.0027933. Epub 2011 Nov 28.

6.

Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.

Flores YN, Velázquez-Cruz R, Ramírez P, Bañuelos M, Zhang ZF, Yee HF Jr, Chang SC, Canizales-Quinteros S, Quiterio M, Cabrera-Alvarez G, Patiño N, Salmerón J.

Mol Biol Rep. 2016 Dec;43(12):1359-1369. Epub 2016 Oct 17.

PMID:
27752939
7.

Association of ALT and the metabolic syndrome among Mexican children.

Elizondo-Montemayor L, Ugalde-Casas PA, Lam-Franco L, Bustamante-Careaga H, Serrano-González M, Gutiérrez NG, Martínez U.

Obes Res Clin Pract. 2014 Jan-Feb;8(1):e79-87. doi: 10.1016/j.orcp.2012.08.191.

PMID:
24548580
8.

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.

Verrijken A, Beckers S, Francque S, Hilden H, Caron S, Zegers D, Ruppert M, Hubens G, Van Marck E, Michielsen P, Staels B, Taskinen MR, Van Hul W, Van Gaal L.

Obesity (Silver Spring). 2013 Oct;21(10):2138-45. doi: 10.1002/oby.20366. Epub 2013 Jun 6.

9.

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.

Hyysalo J, Gopalacharyulu P, Bian H, Hyötyläinen T, Leivonen M, Jaser N, Juuti A, Honka MJ, Nuutila P, Olkkonen VM, Oresic M, Yki-Järvinen H.

Diabetes. 2014 Jan;63(1):312-22. doi: 10.2337/db13-0774. Epub 2013 Sep 5.

10.

Prevalence and predictors of alanine aminotransferase elevation among normal weight, overweight and obese youth in Mexico.

Purcell M, Flores YN, Zhang ZF, Denova-Gutiérrez E, Salmeron J.

J Dig Dis. 2013 Sep;14(9):491-9. doi: 10.1111/1751-2980.12072.

PMID:
23678860
11.

The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals.

Nishioji K, Mochizuki N, Kobayashi M, Kamaguchi M, Sumida Y, Nishimura T, Yamaguchi K, Kadotani H, Itoh Y.

PLoS One. 2015 Oct 20;10(10):e0140427. doi: 10.1371/journal.pone.0140427. eCollection 2015.

12.

Frequency of increased aminotransferases levels and associated metabolic abnormalities in obese and overweight children of an elementary school in Mexico City.

Flores-Calderón J, Gómez-Díaz RA, Rodríguez-Gómez G, Morán-Villota S.

Ann Hepatol. 2005 Oct-Dec;4(4):279-83.

PMID:
16432495
13.

TM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children.

Grandone A, Cozzolino D, Marzuillo P, Cirillo G, Di Sessa A, Ruggiero L, Di Palma MR, Perrone L, Miraglia Del Giudice E.

Pediatr Obes. 2016 Apr;11(2):115-9. doi: 10.1111/ijpo.12032. Epub 2015 Apr 20.

PMID:
25893821
14.

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.

Donati B, Motta BM, Pingitore P, Meroni M, Pietrelli A, Alisi A, Petta S, Xing C, Dongiovanni P, del Menico B, Rametta R, Mancina RM, Badiali S, Fracanzani AL, Craxì A, Fargion S, Nobili V, Romeo S, Valenti L.

Hepatology. 2016 Mar;63(3):787-98. doi: 10.1002/hep.28370. Epub 2016 Jan 14.

PMID:
26605757
15.

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.

Lallukka S, Sevastianova K, Perttilä J, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen VM, Yki-Järvinen H.

Diabetologia. 2013 Apr;56(4):886-92. doi: 10.1007/s00125-013-2829-9. Epub 2013 Jan 19.

PMID:
23334462
16.

Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis.

Di Bonito P, Sanguigno E, Di Fraia T, Forziato C, Boccia G, Saitta F, Iardino MR, Capaldo B.

Metabolism. 2009 Mar;58(3):368-72. doi: 10.1016/j.metabol.2008.10.010.

PMID:
19217453
17.

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.

Stickel F, Buch S, Lau K, Meyer zu Schwabedissen H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, Soyka M, Lerch M, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Kiefer F, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J.

Hepatology. 2011 Jan;53(1):86-95. doi: 10.1002/hep.24017. Epub 2010 Dec 7.

PMID:
21254164
18.

The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.

Valenti L, Rametta R, Ruscica M, Dongiovanni P, Steffani L, Motta BM, Canavesi E, Fracanzani AL, Mozzi E, Roviaro G, Magni P, Fargion S.

BMC Gastroenterol. 2012 Aug 16;12:111.

19.

Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.

Rametta R, Ruscica M, Dongiovanni P, Macchi C, Fracanzani AL, Steffani L, Fargion S, Magni P, Valenti L.

Eur J Clin Invest. 2014 Jul;44(7):627-33. doi: 10.1111/eci.12280.

PMID:
24828988
20.

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

Palmer CN, Maglio C, Pirazzi C, Burza MA, Adiels M, Burch L, Donnelly LA, Colhoun H, Doney AS, Dillon JF, Pearson ER, McCarthy M, Hattersley AT, Frayling T, Morris AD, Peltonen M, Svensson PA, Jacobson P, Borén J, Sjöström L, Carlsson LM, Romeo S.

PLoS One. 2012;7(6):e39362. doi: 10.1371/journal.pone.0039362. Epub 2012 Jun 18.

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