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SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway.

Gen Y, Yasui K, Nishikawa T, Yoshikawa T.

Cancer Sci. 2013 Jul;104(7):810-6. doi: 10.1111/cas.12155. Epub 2013 Apr 16.


A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin.

Huang Y, Xi Q, Chen Y, Wang J, Peng P, Xia S, Yu S.

Anticancer Drugs. 2013 Oct;24(9):889-98. doi: 10.1097/CAD.0b013e328363c64e.


Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.

Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML.

Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22.


Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway.

Li B, Tsao SW, Li YY, Wang X, Ling MT, Wong YC, He QY, Cheung AL.

Int J Cancer. 2009 Dec 1;125(11):2576-85. doi: 10.1002/ijc.24675.


Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway.

Ramakrishnan V, Kimlinger T, Haug J, Painuly U, Wellik L, Halling T, Rajkumar SV, Kumar S.

PLoS One. 2012;7(11):e50005. doi: 10.1371/journal.pone.0050005. Epub 2012 Nov 21.


Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.

Rho O, Kiguchi K, Jiang G, DiGiovanni J.

Mol Carcinog. 2014 Nov;53(11):871-82. doi: 10.1002/mc.22046. Epub 2013 Sep 20.


Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.

Jhanwar-Uniyal M, Gillick JL, Neil J, Tobias M, Thwing ZE, Murali R.

Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.


Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.

Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF.

Cell Death Dis. 2014 Mar 13;5:e1114. doi: 10.1038/cddis.2014.43.


Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.

Li Y, Wang X, Yue P, Tao H, Ramalingam SS, Owonikoko TK, Deng X, Wang Y, Fu H, Khuri FR, Sun SY.

J Biol Chem. 2013 May 10;288(19):13215-24. doi: 10.1074/jbc.M113.463679. Epub 2013 Mar 27.


Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.

Harada K, Miyake H, Kumano M, Fujisawa M.

Br J Cancer. 2013 Oct 29;109(9):2389-95. doi: 10.1038/bjc.2013.602. Epub 2013 Oct 3.


The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells.

Li H, Gao Q, Guo L, Lu SH.

Cancer Biol Ther. 2011 Jun 1;11(11):950-8. Epub 2011 Jun 1.


The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206.

Wang H, Huang F, Wang J, Wang P, Lv W, Hong L, Li S, Zhou J.

Cell Cycle. 2015;14(2):232-42. doi: 10.4161/15384101.2014.977096.


Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes.

Ju SJ, Zhao Y, Chang X, Guo L.

Int J Mol Med. 2014 Jul;34(1):153-9. doi: 10.3892/ijmm.2014.1769. Epub 2014 May 5.


SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.

Gen Y, Yasui K, Zen Y, Zen K, Dohi O, Endo M, Tsuji K, Wakabayashi N, Itoh Y, Naito Y, Taniwaki M, Nakanuma Y, Okanoue T, Yoshikawa T.

Cancer Genet Cytogenet. 2010 Oct 15;202(2):82-93. doi: 10.1016/j.cancergencyto.2010.01.023.


MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K/AKT signaling pathway.

Nie ZC, Weng WH, Shang YS, Long Y, Li J, Xu YT, Li Z.

Int J Clin Exp Pathol. 2015 May 1;8(5):4745-54. eCollection 2015.


The crucial role of SRPK1 in TGF-β-induced proliferation and apoptosis in the esophageal squamous cell carcinomas.

Ren G, Sheng L, Liu H, Sun Y, An Y, Li Y.

Med Oncol. 2015 Jul;32(7):209. doi: 10.1007/s12032-015-0654-3. Epub 2015 Jun 23.


Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast cancer.

Chen X, Zhao M, Hao M, Sun X, Wang J, Mao Y, Zu L, Liu J, Shen Y, Wang J, Shen K.

Mol Cancer Res. 2013 Oct;11(10):1269-78. doi: 10.1158/1541-7786.MCR-13-0212. Epub 2013 Jun 27.


Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells.

Jiang S, Zou Z, Nie P, Wen R, Xiao Y, Tang J.

PLoS One. 2015 Jul 15;10(7):e0132880. doi: 10.1371/journal.pone.0132880. eCollection 2015.


Thioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo.

Li H, Juan L, Xia L, Wang Y, Bao Y, Sun G.

Med Sci Monit. 2016 Jul 25;22:2624-34.


Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS.

J Biol Chem. 2014 Sep 5;289(36):25227-40. doi: 10.1074/jbc.M114.554881. Epub 2014 Jul 2.

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