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Items: 1 to 20 of 174

1.

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

Kim KH, Chen CC, Monzon RI, Lau LF.

Mol Cell Biol. 2013 May;33(10):2078-90. doi: 10.1128/MCB.00049-13. Epub 2013 Mar 18.

2.

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

Borkham-Kamphorst E, Schaffrath C, Van de Leur E, Haas U, Tihaa L, Meurer SK, Nevzorova YA, Liedtke C, Weiskirchen R.

Biochim Biophys Acta. 2014 May;1843(5):902-14. doi: 10.1016/j.bbamcr.2014.01.023. Epub 2014 Jan 31.

3.

CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.

Borkham-Kamphorst E, Steffen BT, Van de Leur E, Haas U, Tihaa L, Friedman SL, Weiskirchen R.

Cell Signal. 2016 Jan;28(1):34-42. doi: 10.1016/j.cellsig.2015.10.013. Epub 2015 Oct 26.

4.

CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.

Kim KH, Chen CC, Alpini G, Lau LF.

J Clin Invest. 2015 May;125(5):1886-900. doi: 10.1172/JCI79327. Epub 2015 Mar 30.

5.

The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.

Chen CC, Kim KH, Lau LF.

Oncogene. 2016 Mar 10;35(10):1314-23. doi: 10.1038/onc.2015.190. Epub 2015 Jun 1.

6.

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.

Jun JI, Lau LF.

Nat Cell Biol. 2010 Jul;12(7):676-85. doi: 10.1038/ncb2070. Epub 2010 Jun 6. Erratum in: Nat Cell Biol. 2010 Dec;12(12):1249.

7.

Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response.

Borkham-Kamphorst E, Steffen BT, Van de Leur E, Tihaa L, Haas U, Woitok MM, Meurer SK, Weiskirchen R.

Biochim Biophys Acta. 2016 Nov;1863(11):2604-2612. doi: 10.1016/j.bbamcr.2016.07.006. Epub 2016 Jul 22.

8.

Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.

Juric V, Chen CC, Lau LF.

Mol Cell Biol. 2009 Jun;29(12):3266-79. doi: 10.1128/MCB.00064-09. Epub 2009 Apr 13.

9.

Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.

Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM.

Hepatology. 2006 Nov;44(5):1267-77.

PMID:
17058265
10.

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.

Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner DA.

Hepatology. 2012 Dec;56(6):2316-27. doi: 10.1002/hep.25938.

11.

Origin of myofibroblasts in the fibrotic liver in mice.

Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305. doi: 10.1073/pnas.1400062111. Epub 2014 Jul 29.

12.

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.

Lan T, Kisseleva T, Brenner DA.

PLoS One. 2015 Jul 29;10(7):e0129743. doi: 10.1371/journal.pone.0129743. eCollection 2015.

13.

Fibronectin extra domain-A promotes hepatic stellate cell motility but not differentiation into myofibroblasts.

Olsen AL, Sackey BK, Marcinkiewicz C, Boettiger D, Wells RG.

Gastroenterology. 2012 Apr;142(4):928-937.e3. doi: 10.1053/j.gastro.2011.12.038. Epub 2011 Dec 24.

14.

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

Klein S, Rick J, Lehmann J, Schierwagen R, Schierwagen IG, Verbeke L, Hittatiya K, Uschner FE, Manekeller S, Strassburg CP, Wagner KU, Sayeski PP, Wolf D, Laleman W, Sauerbruch T, Trebicka J.

Gut. 2017 Jan;66(1):145-155. doi: 10.1136/gutjnl-2015-309600. Epub 2015 Sep 17.

PMID:
26385087
15.

CCN1/CYR61: the very model of a modern matricellular protein.

Lau LF.

Cell Mol Life Sci. 2011 Oct;68(19):3149-63. doi: 10.1007/s00018-011-0778-3. Epub 2011 Jul 31. Review.

16.

Hedgehog controls hepatic stellate cell fate by regulating metabolism.

Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM.

Gastroenterology. 2012 Nov;143(5):1319-29.e1-11. doi: 10.1053/j.gastro.2012.07.115. Epub 2012 Aug 8.

17.

Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo.

Jiang JX, Venugopal S, Serizawa N, Chen X, Scott F, Li Y, Adamson R, Devaraj S, Shah V, Gershwin ME, Friedman SL, Török NJ.

Gastroenterology. 2010 Oct;139(4):1375-84. doi: 10.1053/j.gastro.2010.05.074. Epub 2010 Jun 1.

18.

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis.

Borkham-Kamphorst E, Huss S, Van de Leur E, Haas U, Weiskirchen R.

Liver Int. 2012 Oct;32(9):1342-53. doi: 10.1111/j.1478-3231.2012.02837.x. Epub 2012 Jun 15.

PMID:
22698069
19.

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

Jiang JX, Chen X, Serizawa N, Szyndralewiez C, Page P, Schröder K, Brandes RP, Devaraj S, Török NJ.

Free Radic Biol Med. 2012 Jul 15;53(2):289-96. doi: 10.1016/j.freeradbiomed.2012.05.007. Epub 2012 May 19.

20.

Cellular senescence controls fibrosis in wound healing.

Jun JI, Lau LF.

Aging (Albany NY). 2010 Sep;2(9):627-31.

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