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HUMN project initiative and review of validation, quality control and prospects for further development of automated micronucleus assays using image cytometry systems.

Fenech M, Kirsch-Volders M, Rossnerova A, Sram R, Romm H, Bolognesi C, Ramakumar A, Soussaline F, Schunck C, Elhajouji A, Anwar W, Bonassi S.

Int J Hyg Environ Health. 2013 Aug;216(5):541-52. doi: 10.1016/j.ijheh.2013.01.008. Epub 2013 Mar 16. Review.


The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future.

Fenech M, Holland N, Zeiger E, Chang WP, Burgaz S, Thomas P, Bolognesi C, Knasmueller S, Kirsch-Volders M, Bonassi S.

Mutagenesis. 2011 Jan;26(1):239-45. doi: 10.1093/mutage/geq051. Review.


Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring.

Decordier I, Papine A, Plas G, Roesems S, Vande Loock K, Moreno-Palomo J, Cemeli E, Anderson D, Fucic A, Marcos R, Soussaline F, Kirsch-Volders M.

Mutagenesis. 2009 Jan;24(1):85-93. doi: 10.1093/mutage/gen057. Epub 2008 Oct 14.


In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring.

Hayashi M, MacGregor JT, Gatehouse DG, Adler ID, Blakey DH, Dertinger SD, Krishna G, Morita T, Russo A, Sutou S.

Environ Mol Mutagen. 2000;35(3):234-52.


In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

Hayashi M, MacGregor JT, Gatehouse DG, Blakey DH, Dertinger SD, Abramsson-Zetterberg L, Krishna G, Morita T, Russo A, Asano N, Suzuki H, Ohyama W, Gibson D; In Vivo Micronucleus Assay Working Group, IWGT..

Mutat Res. 2007 Feb 3;627(1):10-30. Epub 2006 Dec 6.


Automated image analysis of micronuclei by IMSTAR for biomonitoring.

Decordier I, Papine A, Vande Loock K, Plas G, Soussaline F, Kirsch-Volders M.

Mutagenesis. 2011 Jan;26(1):163-8. doi: 10.1093/mutage/geq063. Review.


An automated scoring procedure for the micronucleus test by image analysis.

Varga D, Johannes T, Jainta S, Schuster S, Schwarz-Boeger U, Kiechle M, Patino Garcia B, Vogel W.

Mutagenesis. 2004 Sep;19(5):391-7.


HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei.

Bonassi S, Fenech M, Lando C, Lin YP, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Jia C, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hrelia P, Krishnaja AP, Lee TK, Migliore L, Mikhalevich L, Mirkova E, Mosesso P, Müller WU, Odagiri Y, Scarffi MR, Szabova E, Vorobtsova I, Vral A, Zijno A.

Environ Mol Mutagen. 2001;37(1):31-45.


Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.

Seager AL, Shah UK, Brüsehafer K, Wills J, Manshian B, Chapman KE, Thomas AD, Scott AD, Doherty AT, Doak SH, Johnson GE, Jenkins GJ.

Mutagenesis. 2014 May;29(3):155-64. doi: 10.1093/mutage/geu008. Epub 2014 Apr 4.


The micronucleus assay in radiation accidents.

Thierens H, Vral A.

Ann Ist Super Sanita. 2009;45(3):260-4. Review.


Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project.

Fenech M, Bonassi S, Turner J, Lando C, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Bigatti MP, Bolognesi C, Cao J, De Luca G, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hadjidekova VV, Hrelia P, Jaworska A, Joksic G, Krishnaja AP, Lee TK, Martelli A, McKay MJ, Migliore L, Mirkova E, Müller WU, Odagiri Y, Orsiere T, Scarfì MR, Silva MJ, Sofuni T, Surralles J, Trenta G, Vorobtsova I, Vral A, Zijno A; HUman MicroNucleus project..

Mutat Res. 2003 Jan 10;534(1-2):45-64. Erratum in: Mutat Res. 2003 Jul 8;538(1-2):185-6. Suralles, Jordi [corrected to Surralles, Jordi].


Scoring of radiation-induced micronuclei in cytokinesis-blocked human lymphocytes by automated image analysis.

Verhaegen F, Vral A, Seuntjens J, Schipper NW, de Ridder L, Thierens H.

Cytometry. 1994 Oct 1;17(2):119-27.


The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps.

Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, Knasmueller S, Fenech M.

Mutat Res. 2008 Jul-Aug;659(1-2):93-108. doi: 10.1016/j.mrrev.2008.03.007. Epub 2008 Apr 11. Review.


Dose estimation using dicentric chromosome assay and cytokinesis block micronucleus assay: comparison between manual and automated scoring in triage mode.

De Amicis A, De Sanctis S, Di Cristofaro S, Franchini V, Regalbuto E, Mammana G, Lista F.

Health Phys. 2014 Jun;106(6):787-97. doi: 10.1097/HP.0000000000000097.


Multi-parameter dose estimations in radiation biodosimetry using the automated cytokinesis-block micronucleus assay with imaging flow cytometry.

Rodrigues MA, Beaton-Green LA, Kutzner BC, Wilkins RC.

Cytometry A. 2014 Oct;85(10):883-93. doi: 10.1002/cyto.a.22511. Epub 2014 Aug 25.


Commentary: critical questions, misconceptions and a road map for improving the use of the lymphocyte cytokinesis-block micronucleus assay for in vivo biomonitoring of human exposure to genotoxic chemicals-a HUMN project perspective.

Kirsch-Volders M, Bonassi S, Knasmueller S, Holland N, Bolognesi C, Fenech MF.

Mutat Res Rev Mutat Res. 2014 Jan-Mar;759:49-58. doi: 10.1016/j.mrrev.2013.12.001. Epub 2014 Jan 8.


Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007.

Fenech M, Holland N, Knasmueller S, Burgaz S, Bonassi S.

Mutagenesis. 2009 Mar;24(2):199-201. doi: 10.1093/mutage/gen065. Epub 2008 Dec 4.


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