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Items: 1 to 20 of 198

1.

A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome.

Liu W, Guo W, Wu J, Luo Q, Tao F, Gu Y, Shen Y, Li J, Tan R, Xu Q, Sun Y.

Biochem Pharmacol. 2013 May 15;85(10):1504-12. doi: 10.1016/j.bcp.2013.03.008. Epub 2013 Mar 15.

PMID:
23506741
2.

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.

Guo W, Liu W, Jin B, Geng J, Li J, Ding H, Wu X, Xu Q, Sun Y, Gao J.

Int Immunopharmacol. 2015 Feb;24(2):232-8. doi: 10.1016/j.intimp.2014.12.009. Epub 2014 Dec 15.

PMID:
25523461
3.

Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition.

Guo W, Hu S, Elgehama A, Shao F, Ren R, Liu W, Zhang W, Wang X, Tan R, Xu Q, Sun Y, Jiao R.

J Pharmacol Sci. 2015 Oct;129(2):101-6. doi: 10.1016/j.jphs.2015.05.003. Epub 2015 May 19.

4.

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation.

Sun Y, Zhao Y, Yao J, Zhao L, Wu Z, Wang Y, Pan D, Miao H, Guo Q, Lu N.

Biochem Pharmacol. 2015 Mar 15;94(2):142-54. doi: 10.1016/j.bcp.2015.02.002. Epub 2015 Feb 10.

PMID:
25677765
5.

3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome.

Wang Y, Wang H, Qian C, Tang J, Zhou W, Liu X, You Q, Hu R.

Biochem Pharmacol. 2016 Feb 1;101:71-86. doi: 10.1016/j.bcp.2015.11.015. Epub 2015 Nov 14.

PMID:
26588861
6.

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.

Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M.

Gut. 2010 Sep;59(9):1192-9. doi: 10.1136/gut.2009.197822. Epub 2010 May 4.

PMID:
20442201
7.

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer.

Guo W, Sun Y, Liu W, Wu X, Guo L, Cai P, Wu X, Wu X, Shen Y, Shu Y, Gu Y, Xu Q.

Autophagy. 2014 Jun;10(6):972-85. doi: 10.4161/auto.28374.

8.

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.

PMID:
23911403
9.

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.

Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M.

Dig Dis. 2012;30 Suppl 1:82-90. doi: 10.1159/000341681. Epub 2012 Oct 11.

PMID:
23075874
10.

Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production.

Hu Y, Mao K, Zeng Y, Chen S, Tao Z, Yang C, Sun S, Wu X, Meng G, Sun B.

J Immunol. 2010 Dec 15;185(12):7699-705. doi: 10.4049/jimmunol.1001099. Epub 2010 Nov 3.

11.

Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.

12.

A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation.

Wang X, Wang S, Hu C, Chen W, Shen Y, Wu X, Sun Y, Xu Q.

Biochem Pharmacol. 2015 Sep 15;97(2):178-88. doi: 10.1016/j.bcp.2015.06.030. Epub 2015 Jul 23.

PMID:
26212544
13.

CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings.

Li Q, Zhang X, Wang W, Li L, Xu Q, Wu X, Gu Y.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):133-41. doi: 10.1016/j.taap.2015.09.025. Epub 2015 Sep 30.

PMID:
26431797
14.

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD.

Immunity. 2010 Mar 26;32(3):379-91. doi: 10.1016/j.immuni.2010.03.003. Epub 2010 Mar 18.

15.

Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation.

Wang X, Sun Y, Zhao Y, Ding Y, Zhang X, Kong L, Li Z, Guo Q, Zhao L.

Biochem Pharmacol. 2016 Apr 15;106:70-81. doi: 10.1016/j.bcp.2016.02.019. Epub 2016 Mar 4.

PMID:
26947454
16.

NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model.

Luo B, Li B, Wang W, Liu X, Xia Y, Zhang C, Zhang M, Zhang Y, An F.

PLoS One. 2014 Aug 19;9(8):e104771. doi: 10.1371/journal.pone.0104771. eCollection 2014.

17.

Lipopolysaccharide/adenosine triphosphate induces IL‑1β and IL-18 secretion through the NLRP3 inflammasome in RAW264.7 murine macrophage cells.

Xie Q, Shen WW, Zhong J, Huang C, Zhang L, Li J.

Int J Mol Med. 2014 Jul;34(1):341-9. doi: 10.3892/ijmm.2014.1755. Epub 2014 Apr 24.

PMID:
24789624
18.

Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes.

Kim Y, Wang W, Okla M, Kang I, Moreau R, Chung S.

J Lipid Res. 2016 Jan;57(1):66-76. doi: 10.1194/jlr.M062828. Epub 2015 Dec 1.

19.

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.

Zheng Q, Ren Y, Reinach PS, She Y, Xiao B, Hua S, Qu J, Chen W.

Exp Eye Res. 2014 Aug;125:1-8. doi: 10.1016/j.exer.2014.05.001. Epub 2014 May 14.

PMID:
24836981
20.

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.

Liu W, Guo W, Hang N, Yang Y, Wu X, Shen Y, Cao J, Sun Y, Xu Q.

Oncotarget. 2016 May 24;7(21):30536-49. doi: 10.18632/oncotarget.8867.

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